Publication Date:
1986-01-24
Description:
A model of a blood vessel was constructed in vitro. Its multilayered structure resembled that of an artery and it withstood physiological pressures. Electron microscopy showed that the endothelial cells lining the lumen and the smooth muscle cells in the wall were healthy and well differentiated. The lining of endothelial cells functioned physically, as a permeability barrier, and biosynthetically, producing von Willebrand's factor and prostacyclin. The strength of the model depended on its multiple layers of collagen integrated with a Dacron mesh.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weinberg, C B -- Bell, E -- New York, N.Y. -- Science. 1986 Jan 24;231(4736):397-400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2934816" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aorta/anatomy & histology/cytology
;
Blood Vessels/*anatomy & histology/physiology
;
Cattle
;
Cells, Cultured
;
Collagen/*physiology
;
Endothelium/anatomy & histology/cytology
;
Microscopy, Electron, Scanning
;
*Models, Cardiovascular
;
Muscle, Smooth, Vascular/anatomy & histology/cytology
;
Polyethylene Terephthalates
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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