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  • bioavailability
  • Springer  (4)
  • American Meteorological Society
  • 1985-1989  (4)
  • 1980-1984
  • 1940-1944
  • 1986  (4)
Collection
Keywords
Publisher
  • Springer  (4)
  • American Meteorological Society
Years
  • 1985-1989  (4)
  • 1980-1984
  • 1940-1944
Year
  • 1
    Electronic Resource
    Electronic Resource
    Oral bioavailability of high-dose metoclopramide (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 41-44 
    Details
    ISSN: 1432-1041
    Keywords: metoclopramide ; high-dose ; bioavailability ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The oral bioavailability of high-dose metoclopramide was studied in 12 patients, who received oral or intravenous (i.v.) metoclopramide in random order with each of 2 consecutive courses of cytotoxic chemotherapy. The terminal half-life of metoclopramide was 7.1±0.4 h (mean±SEM) and was not affected by the route of drug administration. Mean bioavailability was 86.6±4.7% and the range (65–118%) was less than that reported for standard doses. Neither half-life nor bioavailability was significantly correlated with age. Adverse effects were mild and were similar for both oral and iv metoclopramide. Oral high-dose metoclopramide, given in the same doses as for i.v. administration, should therefore be as effective as the i.v. regimen and may be easier to administer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00870983
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of piroximone (MDL 19.205) in healthy volunteers (1986)
    Springer
    European journal of clinical pharmacology 31 (1986), S. 239-242 
    Details
    ISSN: 1432-1041
    Keywords: piroximone ; cardiotonic drug ; pharmacokinetics ; bioavailability ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Six healthy, male subjects received single intravenous and oral doses of piroximone. Plasma piroximone concentrations were assayed up to 8 h after each dose by HPLC. Urinary excretion of the parent compound was also determined. Following the oral dose, piroximone reached peak plasma concentrations within 30 to 90 min. The t1/2 of the terminal decay phase was 2.8 h, the mean apparent volume of distribution was 2.5 l/kg, and the mean total body clearance was 755 ml/min. Mean urinary recovery of parent drug within 24 h was 50% after the intravenous dose and 41% after the oral dose. Renal clearance accounted for approximately 50% of total body clearance. Oral bioavailability, estimated from AUC or urinary recovery, was 80%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00606667
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  • 3
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of dezocine, a new analgesic: Effect of dose and route of administration (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 121-123 
    Details
    ISSN: 1432-1041
    Keywords: dezocine ; opioid analgesics ; pharmacokinetics ; healthy volunteers ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of intravenous (IV) dezocine, and bioavailability of intramuscular (IM) and subcutaneous (SQ) dezocine, were evaluated in healthy male volunteers. Elimination half-life following 5, 10, and 20 mg IV doses averaged 2.6–2.8 h, and was independent of dose. Clearance decreased slightly, although significantly, with dose. After Deltoid IM injection, dezocine was rapidly absorbed (peak level: 0.6 h after dose), with bioavailability 97%. Thus dezocine has extensive distribution, high clearance and short half-life over a range of IV doses. It is rapidly and completely absorbed following IM or SQ administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614208
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  • 4
    Electronic Resource
    Electronic Resource
    Impact of phosphorus availability on modelling phytoplankton dynamics (1986)
    Springer
    Aquatic ecology 20 (1986), S. 225-243 
    Details
    ISSN: 1573-5125
    Keywords: phosphorus ; bioavailability ; nutrient/phytoplankton modelling ; eutrophication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Regulation of phosphorus loading is considered to be the primary method of eutrophication control for many lake systems. It is therefore necessary to have accurate estimates of the forms and bioavailability of all phosphorus sources in order to develop the most cost effective load control measures. Research at Clarkson University, aimed at improving the accuracy of estimates of the form and reactivity of phosphorus loadings to Lake Erie, has revealed a significant difference between the algal-availability of allochthonous and autochthonous particulate phosphorus. This paper presents the results of modifying an existing multi-nutrient phytoplankton model by separating allochthonous phosphorus into three forms: soluble reactive phosphorus (SRP) — immediately available for algal uptake; external ultimately-available phosphorus—not immediately available but converted to an available form at a specific rate; an external refractory phosphorus (ERP)—not available while in the water column. Comparisons between the original and modified models showed that the modified phosphorus dynamics proved to be a viable alternative to the concept of invoking an unexplained soluble phosphorus water column loss term, employed in the original model. The work also demonstrates that the distinction is significant for lakes receiving a significant portion of their external phosphorus load in a particulate (not immediately available) form and having a morphometry and hydrology such that this particulate phosphorus remains in the water column for longer than about two weeks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02291165
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