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  • 2000-2004
  • 1985-1989  (4)
  • 1985  (4)
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  • 2000-2004
  • 1985-1989  (4)
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  • 1
    Publication Date: 1985-03-01
    Print ISSN: 0022-4073
    Electronic ISSN: 1879-1352
    Topics: Physics
    Published by Elsevier
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  • 2
    Publication Date: 2011-08-19
    Description: Hematologic studies were performed on a group of large and small rats which were sacrificed after flying in life sciences shuttle engineering flight SL-3. The results are presented on flight (F) and control (C) 200 gm rats. The small flight animals demonstrated a significant increase in hematocrits, red blood cell counts, hemoglobins and peripheral blood percentages of neutrophils as well as a decrease in percentage of lymphocytes. Erythropoietin (Ep) determinations were similar for the two groups as were the bone marrow an spleen differential counts. In vitro cultures for erythroid colonies of bone marrow showed that in response to different doses of Ep, in all cases where differnces were statistically significant, the F rats had increased colony counts. The changes in red cell parameters could be caused by a decrease in plasma volume. However, no isotopic studies were possible on this flight and this lack points up the need for such studies to determine the red cell mass and plasma volume.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: Physiologist, Supplement (ISSN 0031-9376); 28; S-195
    Format: text
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  • 3
    Publication Date: 2019-06-28
    Description: The effect of a 7-day suspension in a jacket and harness with 20-deg head-down tilt on body weight, food and water consumption, and hematological parameters is investigated experimentally in male Sprague-Dawley rats weighing 150-175 g. The results are presented in graphs and compared with those for unsuspended controls and with published data on rats and humans exposed to microgravity in space flight. Suspended rats are found to have reduced red-blood-cell mass, erythropoiesis, plasma volume (leading to temporarily increased hematocrit), body weight, and food and water consumption; rightward-shifted oxyhemoglobin-dissociation curves; and unchanged platelet count, leucocyte count or PHA reactivity, and red-blood-cell shape distribution. Since many of these effects are also seen in space flight, the present experimental model is considered a promising technique for simulating the hematopoietic effects of microgravity at 1 g.
    Keywords: LIFE SCIENCES (GENERAL)
    Type: Aviation, Space, and Environmental Medicine (ISSN 0095-6562); 56; 419-426
    Format: text
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  • 4
    Publication Date: 2019-06-28
    Description: An experiment conducted on the 10-day Spacelab 1 mission aboard the ninth Space Shuttle flight in November to December 1983 was designed to measure factors involved in the control of erythrocyte turnover that might be altered during weightlessness. Blood samples were collected before, during, and after the flight. Immediately after landing, red cell mass showed a mean decrease of 9.3 percent in the four astronauts. Neither hyperoxia nor an increase in blood phosphate was a cause of the decrease. Red cell survival time and iron incorporation postflight were not significantly different from their preflight levels. Serum haptoglobin did not decrease, indicating that intravascular hemolysis was not a major cause of red cell mass change. An increase in serum ferritin after the second day of flight may have been caused by red cell breakdown early in flight. Erythropoietin levels decreased during and after flight, but preflight levels were high and the decrease was not significant. The space flight-induced decrease in red cell mass may result from a failure of erythropoiesis to replace cells destroyed by the spleen soon after weightlessness is attained.
    Keywords: AEROSPACE MEDICINE
    Type: NASA-TM-58268 , S-548 , NAS 1.15:58268
    Format: application/pdf
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