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  • Polymer and Materials Science  (232)
  • ASTROPHYSICS  (127)
  • Life and Medical Sciences  (95)
  • Humans  (92)
  • Lunar and Planetary Science and Exploration
  • 2015-2019
  • 1990-1994
  • 1985-1989  (546)
  • 1985  (546)
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  • 2015-2019
  • 1990-1994
  • 1985-1989  (546)
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  • 1
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Acta Polymerica 36 (1985), S. 624-627 
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Unter Hernziehung unterschiedlicher Präparationsmethoden wurde die Struktur verdünnter und konzentrierter (0,01 bis 9,8%) Lösungen des starkettigen Polyamidohydrazid (PAH) mittels Elektronenmikroskopie in zwei Lösungsmitteln (DMSO und DMAA) untersucht. Beginnend mit der Konzentration 0,01% erfolgt unterschiedliche Strukturierung in diesen Lösungsmitteln, die bezüglich des Polymers eine unterschiedliche Güte aufweisen. Die Ergebnisse wurden früheren Untersuchungen zur Rheologie konzentrierter PAH-Lösungen in den genannten Lösungsmitteln gegenüber gestellt.
    Notes: The structure of dilute and concentrated solutions (0.01-9.8%) of rigid-chain polyamidohydrazide (PAH) in dimethylsulphoxide and dimethylacetamide was investigated by electron microscopy using various preparation techniques. Starting with a 0.01% concentration, PAH shows two distinct types of structuration in the solvents. The results are compared with previously studied rheological properties of PAH in these solvents.
    Additional Material: 5 Ill.
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  • 2
    Publication Date: 1985-09-06
    Description: The neu oncogene, identified in ethylnitrosourea-induced rat neuroglioblastomas, had strong homology with the erbB gene that encodes the epidermal growth factor receptor. This homology was limited to the region of erbB encoding the tyrosine kinase domain. It was concluded that the neu gene is a distinct novel gene, as it is not coamplified with sequences encoding the EGF receptor in the genome of the A431 tumor line and it maps to human chromosome 17.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schechter, A L -- Hung, M C -- Vaidyanathan, L -- Weinberg, R A -- Yang-Feng, T L -- Francke, U -- Ullrich, A -- Coussens, L -- CA 39964-01/CA/NCI NIH HHS/ -- GM 26105/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1985 Sep 6;229(4717):976-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2992090" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Neoplasm/*genetics ; Chromosome Mapping ; Chromosomes, Human, 16-18 ; DNA, Neoplasm/*genetics ; Genes ; Genetic Linkage ; Humans ; Neoplasm Proteins/*genetics ; Neuroblastoma/genetics ; Neuroglia ; *Oncogenes ; Rats ; Receptor, Epidermal Growth Factor ; Receptors, Cell Surface/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 1985-04-19
    Description: Cerebellar Purkinje neurons accumulated propidium iodide, granular blue, and horseradish peroxidase conjugated to wheat germ agglutinin but not unconjugated horseradish peroxidase, bisbenzimide, or Evans blue when these compounds were infused into the lateral cerebral ventricles of awake, unrestrained rats. Accumulation of propidium iodide by Purkinje neurons of the vermis was associated with a reproducible behavioral abnormality characterized by truncal tremor, ataxia, and nystagmus. Both the accumulation of propidium iodide in Purkinje cells and the behavioral abnormality were prevented by prior intracerebroventricular administration of ouabain or colchicine, drugs that block neuronal transport processes. The ability of cerebellar Purkinje neurons to extract small and large molecules from the cerebrospinal fluid has important implications for their physiology and pathology.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Borges, L F -- Elliott, P J -- Gill, R -- Iversen, S D -- Iversen, L L -- New York, N.Y. -- Science. 1985 Apr 19;228(4697):346-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2580350" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bisbenzimidazole/metabolism ; Cerebrospinal Fluid/*physiology ; Dendrites/physiology ; Evans Blue/metabolism ; Horseradish Peroxidase/metabolism ; Humans ; Male ; Propidium/metabolism/pharmacology ; Purkinje Cells/*metabolism/physiology ; Rats ; Rats, Inbred Strains ; Tremor/chemically induced/physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 1985-05-24
    Description: The circumsporozoite (CS) protein of the human malaria parasite Plasmodium falciparum may be the most promising target for the development of a malaria vaccine. In this study, proteins composed of 16, 32, or 48 tandem copies of a tetrapeptide repeating sequence found in the CS protein were efficiently expressed in the bacterium Escherichia coli. When injected into mice, these recombinant products resulted in the production of high titers of antibodies that reacted with the authentic CS protein on live sporozoites and blocked sporozoite invasion of human hepatoma cells in vitro. These CS protein derivatives are therefore candidates for a human malaria vaccine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, J F -- Hockmeyer, W T -- Gross, M -- Ballou, W R -- Wirtz, R A -- Trosper, J H -- Beaudoin, R L -- Hollingdale, M R -- Miller, L H -- Diggs, C L -- New York, N.Y. -- Science. 1985 May 24;228(4702):958-62.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2988125" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antibody Formation ; Antigens, Surface/genetics/*immunology ; Carcinoma, Hepatocellular ; Cell Line ; Cloning, Molecular ; Cross Reactions ; DNA, Recombinant ; Escherichia coli/genetics ; Humans ; Liver Neoplasms ; Malaria/*prevention & control ; Mice ; Plasmodium/immunology ; Plasmodium falciparum/genetics/*immunology/physiology ; *Protozoan Proteins ; Vaccines/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1985-10-04
    Description: The T-cell tropic retrovirus of macaque monkeys STLV-III has morphologic, growth, and antigenic properties indicating that it is related to HTLV-III/LAV, the etiologic agent of the acquired immune deficiency syndrome (AIDS) in humans. Four of six rhesus monkeys died within 160 days of STLV-III inoculation with a wasting syndrome, opportunistic infections, a primary retroviral encephalitis, and immunologic abnormalities including a decrease in T4+ peripheral blood lymphocytes. These data show that an immunodeficiency syndrome can be produced experimentally in a nonhuman primate by an agent from the HTLV-III/LAV group of retroviruses. The STLV-III-macaque system will thus provide a useful model for the study of antiviral agents and vaccine development for human AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Letvin, N L -- Daniel, M D -- Sehgal, P K -- Desrosiers, R C -- Hunt, R D -- Waldron, L M -- MacKey, J J -- Schmidt, D K -- Chalifoux, L V -- King, N W -- AI 20729/AI/NIAID NIH HHS/ -- CA 34979/CA/NCI NIH HHS/ -- CA 38205/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Oct 4;230(4721):71-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2412295" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*microbiology/pathology ; Animals ; Brain/pathology ; Deltaretrovirus ; *Disease Models, Animal ; Epitopes/analysis ; Humans ; Interleukin-2 ; Leukocyte Count ; Lymphocyte Activation ; Macaca mulatta ; Microscopy, Electron ; Pancreas/pathology ; *Retroviridae ; T-Lymphocytes/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2019-06-28
    Description: A new method to attack the question of the 'missing' globular clusters in the bulge of M31 is used. Image-processing techniques were used on 13 videocamera fields to obtain an accurate photometric census of stellar objects in M31's bulge down to a limiting B magnitude of 21. This luminosity distribution is compared with the Bahcall-Soneira model of galactic foreground stars. A statistically significant excess of bright images in the luminosity range of globular clusters at M31's distance is found. If the optical candidates considered prove to be globular clusters, they would double the number of known globular clusters in the surveyed region. The colors of a subsample of the candidates are the same as those of the known globular clusters. It is concluded that the previously observed flattening away from a de Vaucouleurs law in the radial distribution of M31 may be an observational selection effect. As an offshoot of this analysis, no evidence is found for very luminous stars in the inner bulge of M31. The lack of such stars indicates that there has not been active star formation (with a normal IMF) in the recent past. Coupled with the existence of many planetary nebulae in the bulge, this may strengthen the case for a galactic wind in M31's bulge.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 290; 140-153
    Format: text
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  • 7
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two studies are diescribed in which synthetic peptides have been designed and examined to address biochemical problems inherent in hydorphobic environments: (1) The cyclic hexapeptide cyclo-(D-Tyr(Bzl)-Gly-Ile-Leu-Gln-Pro) was synthesized as a model of an interior β-turn from the protein lysozyme. Conformational analysis by proton nmr methods, including two-dimensional nulcear Overhauser effect spectroscopy, revealed that the model peptide adopts one conformation in chloroform/dimethyl sulfoxide (98.2) and tetramethylene sulfone solutions. The conformation consists of two linked β-turns, one with the same sequence (Gly-Ile-Leu-Gln) and geometry (Type I) as the protein turn. (2) Major portions of the λ-receptor protein (LamB) signal sequences from E. coli wildtype and mutant strains have been synthesized. The conformational properties and membrane interactions of these synthetic signal peptides correlate with the in vivo export function of the wild type and mutant strains. Functional signal sequences are significantly richer in α-helix in aaqueous trifluoroethanol, lysolecithin, or sodium do-decyl sulfate solution than is a nonfunctional mutant signal sequence.
    Additional Material: 14 Ill.
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  • 8
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 10 (1985), S. 87-103 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The emulsion copolymerization kinetics of styrene-butyl acrylate was studied in a batch process. The effect of the initiator, emulsifier, chain transfer agent and monomer concentration on copolymerization rate and molecular weight distribution is discussed. Thermal and viscoelastic properties of copolymers were measured. It was found that the n-dodecylthiol introduced into the reactor with the monomers did not affect the copolymerization rate (no redox reaction with the initiator) but the molecular weight was strongly dependent upon its concentration. These two kinetic parameters increase with increasing the butyl acrylate concentration.
    Additional Material: 9 Ill.
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  • 9
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Styrene (S)-Methyl methacrylate (MMA) copolymers have been synthesized via batch and semicontinuous processes. The copolymers obtained in both processes were richer in styrene than the initial monomers composition. This fact is strongly influenced by the solubility of MMA in water. The experimental results also showed the existence of an inverse relationship between initiator concentration and molecular weight and consequently in the flow properties of the materials. Furthermore, the molecular weight and flow properties did not show an important dependence on emulsifier content. It was found that the rate of copolymerization was an inverse function of the electrolyte present in the reaction medium. Comparison between copolymers made via batch and semicontinuously pointed out that in general the materials made in a batch process have lower viscosity and elasticity than its semicontinuous counterparts.
    Additional Material: 7 Ill.
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  • 10
    Electronic Resource
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 28 (1985), S. 229-239 
    ISSN: 0730-2312
    Keywords: cell surface ; galactosyltransferase ; immunochemical localization ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: A cell surface UDP-galactose:N-acetylglucosamine galactosyltransferase (GT) has been directly localized on bovine cells in tissue culture by immunohistochemical techniques. A conventional rabbit heteroantiserum was prepared against an affinity-purified soluble form of GT from bovine milk, and a monospecific IgG fraction was isolated by affinity chromatography on a GT adsorbent. As demonstrated by indirect immunofluorescence, antigen to this antibody is present on the surface of all three bovine cell lines tested. It was uniformly distributed over the exposed membrane surface of fixed cells. Exposure of living cells to the anti-GT antibody resulted in its time-dependent aggregation in the plane of the membrane. Antigen (GT) was released from the membrane surface by trypsin digestion, and its reappearance required protein synthesis, since cycloheximide effectively prevented repopulation of the cell surface.
    Additional Material: 4 Ill.
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