ISSN:
0192-253X
Keywords:
BrdU
;
rDNA
;
Drosophila
;
Life and Medical Sciences
;
Genetics
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
Notes:
We demonstrate that Bromodeoxyuridine (BrdU)-induced reductions of the ribosomal RNA cistrons (rDNAs) are observed in Drosophila virilis, and Drosophila busckii, but not in karyotypically normal adults or larvae of Drosophila melanogaster. However, BrdU does reduce the redundancy of the rDNAs of XO D melanogaster males, in which a compensatory response is evidenced in the untreated XO sibling controls. These results suggest that the BrdU-rDNA interaction is specific to events which modulate rDNA redundancy. Further, both thymidine and deoxycytidine “reverse” the BrdU effect in D virilis, an observation which is inconsistent with current working hypotheses describing the mechanisms of BrdUs effects.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/dvg.1020050202
Permalink