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  • healthy volunteers  (11)
  • Ultrastructure  (9)
  • bioavailability  (6)
  • Lepidoptera  (5)
  • 42.55
  • Scolytidae
  • Springer  (36)
  • American Association of Petroleum Geologists
  • American Chemical Society
  • American Geophysical Union
  • Frontiers Media SA
  • 1980-1984  (36)
  • 1920-1924
  • 1984  (36)
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Schlagwörter
Verlag/Herausgeber
  • Springer  (36)
  • American Association of Petroleum Geologists
  • American Chemical Society
  • American Geophysical Union
  • Frontiers Media SA
Erscheinungszeitraum
  • 1980-1984  (36)
  • 1920-1924
Jahr
  • 1
    Digitale Medien
    Digitale Medien
    Influence of alaproclate on antipyrine metabolite formation in man (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 447-452 
    Details
    ISSN: 1432-1041
    Schlagwort(e): alaproclate ; antipyrine clearance ; serotonin reuptake inhibitor ; healthy volunteers ; antipyrine metabolism ; metabolite clearance ; alaproclate kinetics ; inhibition of drug metabolism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Alaproclate, a selective serotonin reuptake inhibitor, presently undergoing clinical trial for the treatment of major depressive disorders, has been shown to inhibit hexobarbital metabolism in mice. In the present study the influence of oral alaproclate on the total plasma clearance of antipyrine and on the formation of its metabolites was investigated in 10 healthy volunteers. The peak level of alaproclate was reached after about 1.5 h, and after a distribution phase, its plasma elimination half-life was between 3.0 and 3.5 h. Antipyrine tests were performed before treatment, during the first four doses and after the seventh dose of alaproclate 200 mg/day. During treatment, total plasma antipyrine clearance and the clearance for production of all antipyrine metabolites were reduced by 30%, indicating non-selective inhibition of oxidative drug-metabolizing enzyme activity in man by alaproclate. After the last dose of alaproclate, antipyrine plasma clearance and the clearance to its metabolites returned to control values. In order to allow more detailed evaluation of the results, the time course of the clearances for production of metabolites was investigated. This revealed that the extent of inhibition of metabolite formation by alaproclate was dependent on the plasma alaproclate level, indicating a rapidly reversible inhibition.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00549593
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Sex attractant for three species of the genusOncocnemis: O. chandleri (Grt.),O. cibalis (Grt.), andO. mackiei (B. & Benj.) (Lepidoptera: Noctuidae) (1984)
    Springer
    Journal of chemical ecology 10 (1984), S. 1701-1706 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Lepidoptera ; Noctuidae ; Oncocnemis chandleri ; Oncocnemis cibalis ; Oncocnemis mackiei ; (5E7Z)-5 ; 7-dodecadienyl acetate ; (Z)-7-dodecenyl acetate ; sex attractant
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Oncocnemis chandleri, O. cibalis, andO. mackiei were attracted to chemically baited traps in the field. In all three cases, (5E,7Z)-dodecadienyl acetate was a key component for attraction. Attraction ofO. chandleri to traps baited with the (5E,7Z)-dodecadienyl acetate was inhibited by addition of (Z)-7-dodecenyl acetate.O. cibalis required both (5E,7Z)-dodecadienyl acetate and (Z)-7-dodecenyl acetate for attraction. Electroantennogram responses for the three species are also reported.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00987356
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Pheromone production by axenically rearedDendroctonus ponderosae andIps paraconfusus (Coleoptera: Scolytidae) (1984)
    Springer
    Journal of chemical ecology 10 (1984), S. 281-290 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Dendroctonus ponderosae ; Ips paraconfusus ; Coleoptera ; Scolytidae ; axenic rearing ; monoterpenes ; aggregation pheromones ; trans-verbenol ; exo-brevicomin ; ipsenol ; ipsdienol
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Mountain pine beetles,Dendroctonus ponderosae Hopkins, and California five-spined ips,Ips paraconfusus Lanier, were reared axenically from surface-sterilized eggs on aseptic pine phloem. After 24 hr in host logs, axenip femaleD. ponderosae and maleI. paraconfusus produced the aggregation pheromones,trans-verbenol (D. ponderosae), and ipsenol and ipsdienol (I. paraconfusus). Emergent, axenically reared maleD. ponderosae contained normal amounts of the pheromoneexo-brevicomin. Axenic femaleD. ponderosae treated with juvenile hormone or exposed to vapors of α-pinene, produced the pheromonetrans-verbenol. By 25–35 days after eclosion, axenic females exposed to α-pinene vapors produced over six times as muchtrans-verbenol as wild females, suggesting that while microorganisms in wild females may producetrans-verbenol, they may also inhibit production of the pheromone or use it as a substrate.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00987856
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    The effect of triplet quenchers on vapor-phase dye-laser performance (1984)
    Springer
    Applied physics 34 (1984), S. 83-86 
    Details
    ISSN: 1432-0649
    Schlagwort(e): 33.50 ; 34.50 ; 42.55
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract An XeF pumped vapor phase POPOP dye laser with a pulse duration of 300 ns was obtained when trans-stilbene was used as triplet quencher. An energy conversion efficiency of 7,5% with a peak power efficiency of 12% was measured.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00697952
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Transverse mode dynamics in a free-electron laser (1984)
    Springer
    Applied physics 33 (1984), S. 9-16 
    Details
    ISSN: 1432-0649
    Schlagwort(e): 42.60 ; 42.20 ; 42.55
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract We derive the most general equations of motion for the electrons and the electromagnetic field in a free-electron laser including the effects of diffraction and pulse propagation. The field evolution is expressed in terms of the amplitudes and phases of a complete set of transverse modes. The analytic solution is given in the small-signal regime, where the theory is shown to be in excellent agreement with a recent experiment at Orsay.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00690020
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Optical klystron experiments for the ACO storage ring Free Electron Laser (1984)
    Springer
    Applied physics 34 (1984), S. 207-219 
    Details
    ISSN: 1432-0649
    Schlagwort(e): 42.60 ; 42.55
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Physik
    Notizen: Abstract To improve the gain in the Orsay storage ring Free Electron Laser (FEL) experiment, the 17 period permanent magnet undulator has been modified to form an optical klystron (OK). We report the measurement of spontaneous emission and the effects on it of energy spread and angular spread. Gain and laser induced bunch lengthening measurements with the OK are also reported and are in very good agreement with the FEL classical theory. The spontaneous emission spectrum which is easy to measure with good signal to noise ratio, turns out to be a very good diagnostic tool forenergy spread and angular spread measurements on storage rings. The factor of four increase in the small gain obtained by converting the undulator NOEL into an OK was the critical factor in the recent operation of the ACO storage ring laser above threshold.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00697637
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Length and shape of enamel crystals (1984)
    Springer
    Calcified tissue international 36 (1984), S. 550-555 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Enamel crystals ; Length ; Shape ; Apatite ; Ultrastructure
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary An original method for fractionating and preparing isolated crystals of homogeneous size was developed. It was demonstrated that enamel apatite crystals are at least 100 µm long. The flexibility of the very long crystallites was demonstrated. Crystal curvatures, accounting for the irregular course of the prisms through the enamel thickness, were visualized and measured. It was shown that in the deep forming enamel layer, lateral branches may grow out of the crystals and crystal fusing often occurs, inducing the crystallites to assume pyramidal shapes with their wide bases pointing toward the dentino-enamel junction and one or two tops toward Tomes' processes. During the maturation process, the two tops of the still immature crystals also fuse so that the mature crystals acquire a rodlike aspect, with parallel faces and steplike graduations along thec axis, allowing a close contact between the crystals. These results support the hypothesis that the crystallites would be continuous from the dentino-enamel junction to the surface.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02405364
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    The disposition of inhaled lysine theophylline in volunteers (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 635-637 
    Details
    ISSN: 1432-1041
    Schlagwort(e): theophylline ; inhalation ; saliva-serum distribution ; healthy volunteers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Six healthy volunteers received an iv infusion of 317 mg lysine theophylline (equivalent to 197 mg anhydrous theophylline) in order to calculate theophylline clearance by standard methods. They subsequently received a 20 minute inhalation of nebulised lysine theophylline. Serum and salivary theophylline concentrations were measured and all saliva was collected for the first hour. From these concentrations estimates were made of the distribution of theophylline into the blood and saliva with 40% to 94% identified in the blood. Very high salivary concentrations were reached during the inhalation phase with saliva: serum concentration ratios of between 60 and 1600.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00543500
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of canrenone and metabolites after base hydrolysis following single and multiple dose oral administration of spironolactone (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 441-446 
    Details
    ISSN: 1432-1041
    Schlagwort(e): spironolactone ; canrenone ; metabolites ; pharmacokinetics ; single/multiple oral doses ; healthy volunteers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of canrenone and ‘total metabolites’ after base hydrolysis was studied in eight young volunteers following single and multiple dose oral administration of spironolactone. The plasma levels of canrenone and ‘total metabolites’ were fitted to a two-compartment open model with a first-order absorption process. From our eight normal subjects studied, the harmonic mean of the distributive half-life (t1/2α) of canrenone was found to be 1.66 h, and the harmonic mean of the terminal elimination half-life (t1/2β) to be 22.6 h. Harmonic means of the distributive and elimination half-lives of ‘total metabolites’ after base hydrolysis were 2.48 h and 28.8 h respectively. The accumulation ratio of canrenone was 2.53, whereas that of ‘total metabolites’ was 1.89. Despite the fact that spironolactone has been shown to induce hepatic metabolism of other drugs, no evidence of autoinduction was noted in the present study, as plasma levels of canrenone and ‘total metabolites’ were found to obey a linear two-compartment model with reproducible absorption and disposition after single and multiple doses.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00549592
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Tolerance and pharmacokinetics of A515U, an acyclovir analogue, in healthy volunteers (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 471-475 
    Details
    ISSN: 1432-1041
    Schlagwort(e): acyclovir ; A515U ; 6-deoxyacyclovir ; pharmacokinetics ; prodrug ; antiviral chemotherapy ; healthy volunteers
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A515U (6-deoxyacyclovir) is an analogue of acyclovir devoid of antiviral activity in vitro but which is well absorbed and undergoes conversion to acyclovir after oral administration to rats. The tolerance and pharmacokinetics of various doses of A515U have been studied in 8 healthy volunteers. Single oral doses of 25, 50, 100, 200 and 400 mg A515U and 400 mg acyclovir for comparison were administered to the volunteers at weekly intervals. Concentrations of the parent drug and acyclovir were determined in plasma and urine. The prodrug was well tolerated and did not cause adverse reactions or changes in haematological or biochemical variables. It was well absorbed and conversion to acyclovir was rapid and extensive at all doses. Plasma concentrations of acyclovir achieved with 50 mg A515U orally were comparable to and less variable than those produced by 400 mg acyclovir. A515U was rapidly cleared with a short plasma elimination half life of approximately 0.5 h. The attainment of high plasma concentrations of acyclovir by oral administration of a prodrug may represent an important advance in antiviral chemotherapy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00549597
    Standort Signatur Erwartet Verfügbarkeit
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