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  • LUNAR AND PLANETARY EXPLORATION  (2)
  • Animals  (1)
  • Chemistry  (1)
  • BIOTECHNOLOGY
  • 1980-1984  (4)
  • 1970-1974
  • 1925-1929
  • 1880-1889
  • 1984  (4)
  • 1
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    Polyene toxicity in renal medulla: injury mediated by transport activity (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-04-06
    Description: Polyene antibiotics such as amphotericin and nystatin increase membrane permeability and thus increase the amount of oxygen consumed in active electrolyte transport. In isolated perfused rat kidneys, the polyenes produced extensive injury to the medullary thick ascending limb, a segment of the nephron with limited oxygen supply. This damage was prevented if reabsorptive transport was inhibited by ouabain. Cell death under these circumstances thus appears to be mediated by increased oxygen demand for transport activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brezis, M -- Rosen, S -- Silva, P -- Spokes, K -- Epstein, F H -- AM18078/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1984 Apr 6;224(4644):66-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6322305" target="_blank"〉PubMed〈/a〉
    Keywords: Amphotericin B/adverse effects ; Animals ; Biological Transport, Active/drug effects ; Cell Membrane Permeability/drug effects ; Furosemide/pharmacology ; Glomerular Filtration Rate/drug effects ; Kidney Medulla/*drug effects/pathology ; Loop of Henle/drug effects ; Nystatin/adverse effects ; Ouabain/pharmacology ; Oxygen Consumption/drug effects ; Polyenes/*adverse effects ; Rats ; Sodium/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Relic interstellar grains in Murchison meteorite (1984)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: It is shown that, in the Murchison meteorite, the D/H ratios of hydrogen are unusually high in several separates and in one case up to 30 times the cosmic value of 2 x 10 to the -5th. Many phases show high C-13/C-12 ratios, up to 2.5 times the terrestrial value of 0.011. These C-13-rich and D-rich components of the two chemical elements are not correlated. They are heterogeneously distributed, suggesting that different components in the meteorite originated from different astrophysical sites and at different times. The D-rich hydrogen in the meteorite is probably due to molecules formed by ion-molecule reactions in interstellar clouds while the tiny amount of C-13-rich carbon is probably due to nucleosynthesis in red giant stars as suggested by Swart et al. (1983). Both of these heavy-isotope enriched components survived homogenization in the accumulation and subsequent history of the meteorites.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Nature (ISSN 0028-0836); 311; 544-547
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
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    Saturn's rings - 3-mm low-inclination observations and derived properties (1984)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: To determine a more precise brightness temperature and more accurate properties for Saturn's rings, 3.3 mm low inclination observations have been made at 90 GHz with the Aerospace 4.6 m radio telescope. A mean brightness temperature of 17 plus or minus 4 K has been determined by comparing the data with the variation of the inclination of the total flux from the planet and rings predicted by a simple model with uniformly bright A and B rings. Variation of the normal optical depth from 0.4 to 1.0 resulted in a total variation of about 1.5 K in A and B brightness. A portion of the brightness attributed to ring particle thermal emission has been determined to be at a temperature of 11 plus or minus 5 K. If the maximum particle radius (approximately 5 m) deduced from Voyager bistatic radar observations is correct, results indicate a particle distribution ranging between 1 cm and several meters radius of the form r exp -s with s = 3.3-3.6, or a material absorption coefficient ranging between 3 and 10 times lower than that of pure water ice at 85 K, or both. An increase in the porosity of the ice particles through a decrease in their density will not produce the observed particle albedo. If the rocky material is uniformly distributed, low ring brightness temperature would allow a silicate upper limit of approximately 10 percent by mass; however, the silicate material could be more abundant if it is separated from the icy material.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Icarus (ISSN 0019-1035); 58; 403-411
    Format: text
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    NASA TECHNICAL REPORTS
  • 4
    Electronic Resource
    Electronic Resource
    Kinetics of irreversible dissociation for proteins bound cooperatively to DNA (1984)
    New York : Wiley-Blackwell
    Biopolymers 23 (1984), S. 1249-1259 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We consider the irreversible dissociation kinetics of proteins that bind cooperatively and nonspecifically to DNA. Our model consists of an infinitely long one-dimensional nucleic acid lattice on which are bound protein ligands. A set of adjacent bound proteins forms a cluster of length n. A protein molecule may dissociate from any site within the bound cluster, not only from the ends, as was assumed in a previous model of this process due to Lohman [(1983) Biopolymers 22, 1697-1713]. By considering this additional pathway, we present a more general treatment of the dissociation kinetics of cooperatively bound ligands. We show that dissociation from the (n-2) internal positions of an n-cluster is an important pathway when the initial fractional saturation of the lattice is close to unity and the co operatively is low. When the fractional saturation is initially equal to 1 and the co operatively is low, our model does not give the zero-order dissociation kinetics predicted by the Lohman model.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360230709
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    Paper (German National Licenses)
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