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  • NDE  (5)
  • cimetidine  (5)
  • Springer  (10)
  • Oxford University Press
  • Springer Nature
  • Wiley
  • 2005-2009
  • 1980-1984  (10)
  • 1965-1969
  • 1984  (10)
Collection
Keywords
Publisher
  • Springer  (10)
  • Oxford University Press
  • Springer Nature
  • Wiley
Years
  • 2005-2009
  • 1980-1984  (10)
  • 1965-1969
Year
  • 1
    Electronic Resource
    Electronic Resource
    Ultrasonic reflection from a stressed interface (1984)
    Springer
    Journal of nondestructive evaluation 4 (1984), S. 3-12 
    Details
    ISSN: 1573-4862
    Keywords: Ultrasonic ; stress measurements ; interfacial stress ; NiTi ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract In seeking to develop an NDE technique for verifying the serviceability of NiTi couplers for plumbing unions, it was found that the reflection coefficient for a normally incident ultrasonic wave correlated with the stress level at the NiTi-tubing interface. Current theory pertaining to interface reflection is not complete but, even at present status, there is semiquantitative accord between theoretical predictions and normalized data for reflection coefficient versus stress level. These results are at fixed frequency and with comparable surface roughness. Variation of either frequency or surface roughness further affects the reflection coefficient. Current studies are being pursued to define this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711095
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  • 2
    Electronic Resource
    Electronic Resource
    Differential effects of cimetidine on theophylline metabolic pathways (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 335-340 
    Details
    ISSN: 1432-1041
    Keywords: theophylline ; cimetidine ; drug metabolism ; drug interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of cimetidine (1 g/day) on theophylline disposition and metabolism were examined in smokers and non-smokers for single dose intravenous and chronic oral administration of theophylline. In the intravenous study the effect of cimetidine on plasma theophylline clearance was more marked in smokers (22.7% reduction) than in non-smokers (12.2% reduction). Similarly, in the multiple dose study the effect of cimetidine on theophylline clearance was greater in smokers (28.3% decrease) than in non-smokers (11.3% decrease). The reduction in clearance was largely due to a reduction in metabolic clearances by 3-demethylation (Cl3DM) and 1-demethylation (Cl1DM) with no significant effect on clearance by 8-oxidation (Cl80X). There was a strong correlation between Cl3DM and Cl1DM (r=0.98, p〈0.001) in both control and cimetidine study phases, whereas other correlations between partial clearances were less marked and were not apparent during the cimetidine phase. The results are consistent with the view that 1- and 3-demethylation of theophylline are carried out by a common form of cytochrome P-450 which is selectively induced by cigarette smoking and preferentially inhibited by cimetidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00548764
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of histamine and cimetidine on cholesterol synthesis in human mononuclear leukocytes (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 773-773 
    Details
    ISSN: 1432-1041
    Keywords: human mononuclear leukocytes ; cholesterol synthesis ; cimetidine ; histamine action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541941
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  • 4
    Electronic Resource
    Electronic Resource
    Disposition of clotiazepam: Influence of age, sex, oral contraceptives, cimetidine, isoniazid and ethanol (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 55-59 
    Details
    ISSN: 1432-1041
    Keywords: clotiazepam ; drug interaction ; cimetidine ; isoniazid ; ethanol ; pharmacokinetic ; oral contraceptives ; age
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Factors influencing the disposition of clotiazepam in man were evaluated in a series of pharmacokinetic studies in healthy volunteers given a single 5 mg dose. Old age caused an increased volume of distribution of clotiazepam in women, and its clearance tended to be reduced in elderly men. Use of oral contraceptives, cimetidine, isoniazid or a single dose of ethanol had no significant effect on the kinetics of clotiazepam. Although clotiazepam is biotransformed by microsomal oxidation, its clearance appears to be relatively uninfluenced by factors known to alter the clearance of other oxidized benzodiazepines.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00546709
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of cimetidine and ranitidine on carbamazepine and sodium valproate pharmacokinetics (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 341-343 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; ranitidine ; carbamazepine ; sodium valproate ; pharmacokinetics ; drug metabolism ; inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of a single oral dose (400 mg) of carbamazepine and sodium valproate were compared in peptic ulcer patients before and after four weeks of a therapeutic course of either cimetidine (1 g/day, n=6 subjects) or ranitidine (300 mg/day, n=6 subjects). There was a small (up to 20%) but statistically significant decrease in oral clearance of carbamazepine after cimetidine treatment. A similar fall in sodium valproate clearance in five cimetidine-treated patients was accompanied by a significantly prolonged elimination half-life. No such trends were demonstrated during ranitidine treatment. Since both anticonvulsants are partly metabolized by hepatic mixed function oxidases, an inhibition by cimetidine at this level may be responsible for the observed impairment of clearance. Thus a potentially important clinical interaction may occur in patients taking anticonvulsants and cimetidine concurrently.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542172
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  • 6
    Electronic Resource
    Electronic Resource
    Daytime acid secretion after a single dose of ranitidine and cimetidine — a double blind crossover study (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 177-182 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; ranitidine ; gastric acid secretion ; serum gastrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The purpose of the study was to evaluate the duration of inhibition of acid secretion by single oral doses of cimetidine and ranitidine. Basal and postprandial acid secretion in 6 healthy volunteers were measured for 14 h by intermittent aspiration and prolonged intragastric titration. 400 mg cimetidine reduced daytime acid secretion by 22% and 150 mg ranitidine produced 38% inhibition. Although the elimination half lives of the drugs were similar, ranitidine led to more pronounced inhibition of acid secretion during the later part of the day. The longer duration of pronounced acid inhibition by ranitidine appears to be due solely to its greater potency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630283
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  • 7
    Electronic Resource
    Electronic Resource
    Some computational considerations in eddy-current NDE (1984)
    Springer
    Journal of nondestructive evaluation 4 (1984), S. 39-42 
    Details
    ISSN: 1573-4862
    Keywords: Eddy current ; computer analysis ; numerical methods ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Theoretical calculations of eddy-current phenomena often involve the numerical evaluation of various integral expressions. A discussion of some of the possible evaluation methods and of the factors to be considered in choosing a method is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711099
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  • 8
    Electronic Resource
    Electronic Resource
    The radiographic edge scattering distortion (1984)
    Springer
    Journal of nondestructive evaluation 4 (1984), S. 75-88 
    Details
    ISSN: 1573-4862
    Keywords: object scattering ; edge scattering ; knife edge ; neutron radiography ; buildup factor ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Previously described scattering based edge distortions in optical density scans obtained from a neutron radiographic knife-edge image have been here confirmed using analog Monte Carlo simulation. In an attempt to estimate the effects of additional object scatter on such artifacts, the effect on the edge response of diffusely incident neutrons has been determined both empirically and by Monte Carlo simulation. The diffuse neutron incidence has been found to diminish the relative magnitude of the distortion, offering explanation for the infrequent observation of the corresponding edge scattering halo artifacts. The potential of this edge distortion as a diagnostic indicator of the buildup factor in radiography is suggested and examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566399
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  • 9
    Electronic Resource
    Electronic Resource
    Separation and characterization of stress levels and texture in metal sheet and plate: I. Principles and preliminary experiment (1984)
    Springer
    Journal of nondestructive evaluation 4 (1984), S. 157-163 
    Details
    ISSN: 1573-4862
    Keywords: Residual Stress ; ultrasonics ; metals ; EMATs ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract An approach is proposed for obtaining separate measures of stress anisotropy and texture in metal sheet or plate. The approach is based on the propagation characteristics ofSH n modes of ultrasonic waves. Experimental work has established that differences betweenSH 0 modes with orthogonal directions of propagation provide a measure of stress anisotropy that is insensitive to texture, with the restriction that the pseudosymmetry of the polycrystalline matrix of the sheet or plate is orthorhombic or higher. In the present work, it is argued that the differences between elastic constants associated with orthogonal directions of propagation of higher order modes should provide a meaningful measure of texture. The only requirement is that the texture be sufficiently well developed so that the following inequality is obeyed: ∣C′44−C′55∣〉0.002 $$\bar C$$ with $$\bar C$$ =1/2 (C′44+C′55). HereC′44 andC′55 are the effective shear moduli for planes normal to the sheet or plate surface and at right angles to each other. They are measurable by observing the differences between the phase velocities of theSH 0 and theSH n〉0 modes in the principal directions. By using Electromagnetic Acoustic Transducers (EMATs), the phase velocities can be deduced from the frequencies at which an SH mode of fixed wavelength is optimally excited. This approach has the advantage of being independent of specimen geometry and dimensions other than thickness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566221
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  • 10
    Electronic Resource
    Electronic Resource
    The interaction of ultrasound with contacting asperities: Applications to crack closure and fatigue crack growth (1984)
    Springer
    Journal of nondestructive evaluation 4 (1984), S. 203-212 
    Details
    ISSN: 1573-4862
    Keywords: Acoustic diffraction ; acoustic transmission ; asperity contact ; crack closure ; fatigue cracks ; mode conversion ; NDE ; stress intensity factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The partial contact of two rough fatigue crack surfaces leads to transmission, reflection, diffraction, and mode conversion of an acoustic signal at those contacts. This paper reviews recent experimental and theoretical efforts to understand and quantify such contact on actual fatigue cracks in greater detail. It is shown that the size and density of individual contacts, or asperities, can be estimated from acoustic measurements. Furthermore, it is shown that this information is useful to provide the static stress across a partially closed crack as well as the “effective” stress intensity range which activates fatigue crack propagation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566225
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