Publication Date:
2014-12-17
Description:
Article IL-18 is a member of the IL-1 family of proinflammatory cytokines. Tsutsumi et al. present a crystal structure of IL-18 bound to the extracellular domains of its heterodimeric receptor, providing insight into how its unusual specificity may be targeted pharmacologically. Nature Communications doi: 10.1038/ncomms6340 Authors: Naotaka Tsutsumi, Takeshi Kimura, Kyohei Arita, Mariko Ariyoshi, Hidenori Ohnishi, Takahiro Yamamoto, Xiaobing Zuo, Katsumi Maenaka, Enoch Y. Park, Naomi Kondo, Masahiro Shirakawa, Hidehito Tochio, Zenichiro Kato
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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