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  • Parkinsonism  (1)
  • Springer  (2)
  • American Association for the Advancement of Science
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  • American Society of Hematology
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  • Springer  (2)
  • American Association for the Advancement of Science
  • American Journal of Science
  • American Society of Hematology
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  • 1995-1999
  • 1985-1989  (2)
  • 1980-1984
  • 1975-1979
  • 1965-1969
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  • 1989  (2)
  • 1984
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 37 (1989), S. 391-393 
    ISSN: 1432-1041
    Keywords: Parkinsonism ; acetylator phenotype ; sulphamethazine ; debrisoquine oxidation ; drug polymorphism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Acetylator phenotype has been determined using sulphamethazine in 100 patients with Parkinson's disease and in 93 age-matched normal control subjects. Sixty-nine patients and 54 control subjects were classified as slow acetylators (NS). No relation was found among acetylator polymorphism and age at onset or clinical stage of disease. Amongst slow acetylators, the percentage of acetylated sulphamethazine in plasma was significantly lower in patients than in controls. Despite this finding, the results do not support any relationship between acetylator polymorphism and the risk of developing Parkinson's disease.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-203X
    Keywords: Acidic isoperoxidases ; Basic isoperoxidases ; Capsicum annuum ; Medium ; Sequential release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The establishment of suspension cell cultures from trimmed cotyledons of pepper (Capsicum annuum L.) provides a new experimental system for studying the relationship between release of peroxidase (EC 1.11.1.7) into the free intercellular spaces and plant cell growth. In contrast with several other species, the total peroxidase activity in the medium increased continuously during the post-exponential growth phase of the pepper cell culture, and this was correlated with the growth inhibition of pepper cells cultivated in suspension. The increase in the peroxidase activity in the culture medium was the consequence of a differential release of isoperoxidases, prominently marked by a primary release of basic isoperoxidases, followed by a strong increase in the level of acidic isoperoxidases. Thus, pepper cells cultures constitute a new experimental system for studying the regulation of the sequential release of basic and acidic isoperoxidases, which occurs during the growth cessation of plant cells.
    Type of Medium: Electronic Resource
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