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  • Articles  (491)
  • Chemistry  (465)
  • pharmacokinetics  (26)
  • AIRCRAFT
  • 1980-1984  (491)
  • 1955-1959
  • 1983  (491)
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  • Articles  (491)
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  • 1980-1984  (491)
  • 1955-1959
Year
Journal
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  • 1
    Electronic Resource
    Electronic Resource
    Plasma concentration of disopyramide given as capsules and controlled release tablets (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 199-203 
    Details
    ISSN: 1432-1041
    Keywords: disopyramide ; arrhythmias ; controlled release tablet ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Steady state plasma levels and clinical effects of disopyramide have been compared following administration of standard capsules and controlled release (CR) tablets. Nineteen patients (29–70 years) with atrial or ventricular arrhythmias were treated for two weeks with disopyramide capsules 200 mg t.i.d. and then with CR tablets 300 mg b.i.d. for 14 weeks. After treatment either with capsules or CR tablets, plasma concentrations of disopyramide and its metabolite N-deisopropyldisopyramide were similar within 1 dosage interval. Maximum and minimum concentrations of the parent drug were 10.1±0.9 µmol/l (mean ± SEM) and 5.7±0.5 µmol/l with CR tablets, and 10.2±0.5 µmol/l and 5.6±0.5 µmol/l with standard capsules. The bioavailability of disopyramide was the same after capsules and CR tablets. Disopyramide, independent of the formulation, produced good antiarrhythmic effects. The side-effects reported on questioning were mainly of the anti-cholinergic type and there was no significant difference between the formulations with respect to their incidence, type or severity. Of 16 patients who stated a preference for one of the dosage forms, 11 prefered the CR tablets. The study confirms the good antiarrhythmic effect of disopyramide and shows that the CR preparation permits twice daily administration of disopyramide.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613817
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of underived nucleotides by mass spectrometry using the MBSA-FAB ionization method (1983)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 18 (1983), S. 361-364 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210180812
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  • 3
    Electronic Resource
    Electronic Resource
    Applications of Fourier transform mass spectrometry (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Mass Spectrometry Reviews 2 (1983), S. 389-415 
    Details
    ISSN: 0277-7037
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mas.1280020303
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  • 4
    Electronic Resource
    Electronic Resource
    Analyse Vibrationnelle et Structurale en Série Aliphatique Saturée: 5For Part 4 of this series, see Ref. 4. - Spectres de Vibration de l'Acide Ethylmalonique et de ses Sels Alcalins en Solution Aqueuse (1983)
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 14 (1983), S. 426-433 
    Details
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Raman and infrared spectra of ethylmalonic acid [C2H5CH(COOH)2, C2H5CD(COOD)2] and its potassium salts [C2H5CH(COOH)(COOK), C2H5CD(COOD)(COOK) and C2H5CH(COOK)2, C2H5CD(COOK)2] in aqueous solution were recorded from 3500 to 200 cm-1. The analysis of the polarization of the Raman lines led us to the conclusion that ethylmalonic acid and its dipotassium salt belong to Cs and the acid salt to the C1 group. An assignment of the observed lines as fundamentals is proposed.
    Notes: Les spectres Raman et infrarouge de l'acide éthylmalonique [C2H5CH(COOH)2, C2H5CD(COOD)2] et de ses sels alcalins [C2H5CH(COOH)(COOK), C2H5CD(COOD)(COOK) et C2H5CH(COOK)2, C2H5CD(COOK)2] en solution aqueuse ont été enregistrés de 3500 à 200 cm-1. L'analyse du facteur de dépolarisation nous a permis de conclure que l'acide et le dianion appartiennent au groupe de symétrie Cs le sel acide appartenant au groupe C1. Une attribution des vibrations fondamentales est proposée.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jrs.1250140612
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacodynamic and pharmacokinetic study of oral and intravenous penbutolol (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 529-534 
    Details
    ISSN: 1432-1041
    Keywords: penbutolol ; pharmacokinetics ; blood pressure effect ; heart rate effect ; dose response relationship ; tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The present study was done to establish the dose-response relationships for effects on heart rate and systolic and diastolic blood pressure, tolerance and plasma disappearance kinetics after large intravenous and oral doses of penbutolol. Twelve healthy volunteers were randomly allocated to receive penbutolol (n=8) or placebo (n=4) in this single blind, placebo-controlled investigation. The degree of beta-blockade was measured by standarized exercise tests at work loads selected to produce a heart rate of 150/min without treatment. Penbutolol was given as single i.v. doses of 3, 6 and 12 mg and as 40, 80 and 120 mg once daily for one week, measurements being made 2 and 24 h after the last dose. Penbutolol i.v. did not influence the resting heart rate but it did reduce resting systolic blood pressure in a non-dose dependent manner. Exercise heart rate and systolic pressure were lowered by all the intravenous doses. All oral doses of penbutolol lowered exercise heart rate and systolic blood pressure to the same extent. The reductions in exercise tachycardia was still present after 24 h. After i.v. administration t1/2 was approximately 1.2 h and the volume of distribution was 32–42 l. All doses were well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542123
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  • 6
    Electronic Resource
    Electronic Resource
    Relationships between several pharmacokinetic parameters and psychometric indices of subjective effects of Δ9-tetrahydrocannabinol in man (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 633-637 
    Details
    ISSN: 1432-1041
    Keywords: delta-9-tetrahydrocannabinol ; mood ratings ; pharmacodynamics ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary This study explored the relationships in man between various pharmacological effect of Δ9-tetrahydrocannabinol (THC), plasma THC concentration, and pharmacokinetic parameters of THC. Three male and three female experienced marihuana users smoked two standard marihuana cigarettes. The relationships between heart rate, subjective “high” rating, Linear Mood Scale factors, and plasma THC concentration were assessed. Significant correlations were observed between various Linear Mood Scale factors and pharmacokinetic parameters reflecting the magnitude of drug intake and the degree of temporal dissociation between the time courses of plasma THC concentration and pharmacological effects (tachycardiac effect, “high”). In particular, the disturbed/weird and sensitive/aware mood factors correlated positively with pharmacokinetic measures of drug intake and time lag to effect. A more reliable index of intoxication with THC may be provided by the global subjective “high” rating, rather than other ratings more specific for particular moods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542351
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  • 7
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of gentamicin in very low birth weight preterm infants (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 649-653 
    Details
    ISSN: 1432-1041
    Keywords: gentamicin ; preterm infants ; pharmacokinetics ; low birth weight ; dosage regimens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Low birth weight preterm infants with suspected infection were administered gentamicin intramuscularly every 18 h (2.5 mg/kg) or 24 h (3.0 mg/kg). For both dosage regimens plasma gentamicin levels were monitored during a dosage interval on three separate occasions over a 10 day period. Both regimens gave satisfactory plasma concentrations and there was no important statistically significant difference between the two. The body clearance of gentamicin correlated with gestational age (r=0.76, p〈0.01). The results indicate either regimen may be useful in the clinical situation but from a practical standpoint administration every 24 h may be easier to comply with then every 18 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542216
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  • 8
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of triazolam in geriatric patients (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 91-94 
    Details
    ISSN: 1432-1041
    Keywords: triazolam ; geriatric patients ; hypnotics ; pharmacokinetics ; plasma concentration ; benzodiazepine ; alpha-hydroxytriazolam
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Serum triazolam levels were determined in eight geriatric patients (average age 80 years) on Days 1 and 7 of administration of triazolam 0.25 mg once daily, 1 h after a standard breakfast. Triazolam was rapidly absorbed reaching average peak concentrations of 2.0 and 2.04 ng/ml, 1.5 and 1.38 h after administration on Days 1 and 7, respectively. The mean apparent elimination half-life was 1.41 h (range 0.73–4.13 h) on Day 1 and 1.37 h (range 0.69–3.36 h) on Day 7. There was no significant difference between mean serum triazolam concentrations or pharmacokinetic parameters on Days 1 and 7 of the treatment. Serum samples were also assayed for α-hydroxytriazolam, an active metabolite of triazolam, but none could be detected in any of the samples from Days 1 or 7, assay sensitivity 0.09 ng/2 ml serum. The range of half-lives of triazolam in the patients in the present study is in close agreement with that previously reported in elderly subjects. The study provides further evidence of the lack of change in pharmacokinetic parameters on multiple dosing and that drug accumulation did not occur.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544022
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  • 9
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of Sobrerol in chronic bronchitis (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 209-215 
    Details
    ISSN: 1432-1041
    Keywords: sobrerol ; mucus liquefaction ; pharmacokinetics ; bronchial mucus level ; mass fragmentography ; metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetic profile of Sobrerol, a mucolytic drug, has been studied in patients with acute exacerbations of chronic bronchitis and dense sputum. In addition to measurement of serum and urine levels, the concentration in bronchial mucus was also examined, and their correlation was calculated. Mass fragmentographic analysis was used to assay free sobrerol and its principal urinary metabolites hydrated carvone and glucuronidated sobrerol. After the doses and administration routes used, there appeared to be accumulation of sobrerol in bronchial mucus. This is a feature of great interest and value for a drug which has the specific action of liquefying mucus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613819
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  • 10
    Electronic Resource
    Electronic Resource
    Molmassenverteilung und lösungszustand von linearen polyethylenen, 1. Lichtstreuungs-, viskositäts- und GPC-messungen (1983)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 184 (1983), S. 585-596 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Light scattering, viscosity and GPC measurements were performed on a homologous series of linear polyethylenes with viscosity average molar masses in decahydronaphthalene at 135°C between 1,0 · 105 and 2,7 · 106 g · mol-1 and relatively broad molar mass distributions. 1,2,4-Trichlorobenzene, α-chloronaphthalene, decahydronaphthalene (decalin) and decane were used as solvents. In the case of linear polyethylene in decahydronaphthalene and decane relationships between intrinsic viscosity and weight average molar mass were established. The values of the weight average molar masses obtained by light scattering are considerably higher than those obtained by viscosity and GPC measurements. These discrepancies are explained by molecular aggregation of the polyethylene macromolecules.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1983.021840313
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