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Bioavailability of methotrexate tablets (1982)

Schornagel, J. H. ; Engelen, M. E. A. G. ; Vos, D.

Springer

Pharmacy world & science 4 (1982), S. 89-90

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ISSN: 1573-739X

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract The bioavailability of methotrexate 10 mg tablets has been determined to be 62±16%. After administration of a dose of 30 mg/m2 a maximum plasma concentration of ca. 20. 10−7 mole/l was found after ca. 1.7 h. The methotrexate plasma half-life was 2.4 h. It was concluded that the 10 mg tablet formulation at the dosage investigated is a suitable clinical methotrexate preparation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01962252

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