Publication Date:
1981-11-20
Description:
The hydroxylase cofactor, tetrahydrobiopterin, and its biosynthetic system are localized in dopaminergic nerve terminals in the striatum. This conclusion is based on the nearly equivalent loss of tyrosine hydroxylase and tetrahydrobiopterin and its initial biosynthetic enzyme, guanosine triphosphate cyclohydrolase, after injection of 6-hydroxydopamine into the substantia nigra. The role of the hydroxylase cofactor in the regulation of dopamine synthesis is reassessed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levine, R A -- Miller, L P -- Lovenberg, W -- New York, N.Y. -- Science. 1981 Nov 20;214(4523):919-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6117945" target="_blank"〉PubMed〈/a〉
Keywords:
Aminohydrolases/*metabolism
;
Animals
;
Biopterin/analogs & derivatives/*metabolism
;
Corpus Striatum/drug effects/*metabolism
;
Dopamine/*metabolism
;
GTP Cyclohydrolase/*metabolism
;
Hydroxydopamines/pharmacology
;
Male
;
Pteridines/*metabolism
;
Rats
;
Rats, Inbred Strains
;
Substantia Nigra/drug effects/metabolism
;
Tyrosine 3-Monooxygenase/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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