ISSN:
1744-313X
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Biologie
,
Medizin
Notizen:
An alloantiserum prepared against LyM-1 antigen of the mouse has been analysed in detail. This antiserum, C3H/HeJ anti-CBA/J, has turned out to define two antigens which are specified by independently segregating loci. One of these is Lyb-2.1 or similar antigen specified by a gene located on chromosome 4. The other is identified as LyM-1.2 based on the result that a gene determining alloantigenicity in the Lyb-2- strain is closely linked to Mls with recombination frequency of 0.066 ± 0.028. Since both antigens are expressed preferentially on B lymphocytes and their strain distribution is significantly overlapped, there has been much confusion about LyM-1 antigen. This is overcome by re-evaluating anti-LyM-1.2 serum under the condition in which Lyb-2.1 is not involved in analysis. The strain distribution of LyM-l antigen, its preferential expression on B lymphocytes and close genetic linkage of LyM-l to Mls have been established.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1744-313X.1981.tb01070.x
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