Publication Date:
2013-01-12
Description:
An extensive literature shows that astrocytes exhibit metabotropic glutamate receptor 5 (mGluR5)-dependent increases in cytosolic calcium ions (Ca(2+)) in response to glutamatergic transmission and, in turn, modulate neuronal activity by their Ca(2+)-dependent release of gliotransmitters. These findings, based on studies of young rodents, have led to the concept of the tripartite synapse, in which astrocytes actively participate in neurotransmission. Using genomic analysis, immunoelectron microscopy, and two-photon microscopy of astrocytic Ca(2+) signaling in vivo, we found that astrocytic expression of mGluR5 is developmentally regulated and is undetectable after postnatal week 3. In contrast, mGluR3, whose activation inhibits adenylate cyclase but not calcium signaling, was expressed in astrocytes at all developmental stages. Neuroglial signaling in the adult brain may therefore occur in a manner fundamentally distinct from that exhibited during development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569008/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569008/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Wei -- McConnell, Evan -- Pare, Jean-Francois -- Xu, Qiwu -- Chen, Michael -- Peng, Weiguo -- Lovatt, Ditte -- Han, Xiaoning -- Smith, Yoland -- Nedergaard, Maiken -- NS075177/NS/NINDS NIH HHS/ -- NS078304/NS/NINDS NIH HHS/ -- P51OD011132/OD/NIH HHS/ -- P51RR000165/RR/NCRR NIH HHS/ -- R01 NS075177/NS/NINDS NIH HHS/ -- R01 NS078167/NS/NINDS NIH HHS/ -- R01 NS078304/NS/NINDS NIH HHS/ -- RR00165/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2013 Jan 11;339(6116):197-200. doi: 10.1126/science.1226740.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester, Rochester, NY 14642, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23307741" target="_blank"〉PubMed〈/a〉
Keywords:
Adolescent
;
*Aging
;
Animals
;
Astrocytes/*metabolism
;
Calcium/metabolism
;
*Calcium Signaling
;
Cerebral Cortex/cytology/*metabolism/ultrastructure
;
Female
;
Glutamic Acid/*metabolism
;
Hippocampus/cytology/metabolism/ultrastructure
;
Humans
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Receptor, Metabotropic Glutamate 5
;
Receptors, Metabotropic Glutamate/agonists/*metabolism
;
Synaptic Transmission
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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