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  • 1
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    GABA analogues activate channels of different duration on cultured mouse spinal neurons (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-04-17
    Description: Voltage-clamp recordings from mouse spinal neurons grown in culture were used to study the membrane current fluctuations induced by 12 substances structurally similar to gamma-aminobutyric acid (GABA). Fluctuation analysis provided estimates of the electrical properties of the elementary events underlying these responses. Estimates of the mean conductance of channels activated by all of the substances except glycine did not differ significantly from that estimated for GABA, whereas mean durations of agonist-activated channels all differed significantly from that found for GABA. The results indicate that all of the substances tested except glycine activate channels of similar conductance but of different durations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barker, J L -- Mathers, D A -- New York, N.Y. -- Science. 1981 Apr 17;212(4492):358-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6259733" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/drug effects ; Ion Channels/*drug effects ; Membrane Potentials/drug effects ; Mice ; Neurons/drug effects ; Receptors, Cell Surface/metabolism ; Receptors, GABA-A ; Spinal Nerves/*drug effects ; Structure-Activity Relationship ; Time Factors ; gamma-Aminobutyric Acid/*analogs & derivatives/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Pentobarbital: dual actions to increase brain benzodiazepine receptor affinity (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-03-27
    Description: The binding of [3H]diazepam to benzodiazepine receptors was studied in extensively washed membranes of rat cerebral cortex in the presence of the depressant barbiturate, pentobarbital. Pentobarbital, like the endogenous neurotransmitter gamma-aminobutyric acid (GABA), increased the basal binding and also potentiated the GABA-enhanced binding of [3H]diazepam to benzodiazepine receptors by increasing the apparent affinity of [3H]diazepam for the benzodiazepine receptor. The concentrations of pentobarbital necessary to elicit these effects in vitro are the same as those observed after treatment with pharmacologically relevant doses, suggesting that a common neurochemical association may exist between these types of compounds.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Skolnick, P -- Moncada, V -- Barker, J L -- Paul, S M -- New York, N.Y. -- Science. 1981 Mar 27;211(4489):1448-50.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6258230" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cerebral Cortex/drug effects ; Chlorides/metabolism ; Diazepam/metabolism ; Male ; Pentobarbital/*pharmacology ; Rats ; Receptors, Drug/*drug effects/metabolism ; Receptors, GABA-A ; Stimulation, Chemical ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Diazepam and (--)-pentobarbital: fluctuation analysis reveals different mechanisms for potentiation of gamma-aminobutyric acid responses in cultured central neurons. (1981)
    National Academy of Sciences
    Details
    Publication Date: 1981-11-01
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 4
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    A sampling procedure to guide the collection of narrow-band, high-resolution spatially and spectrally representative reflectance data (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: A multistage sampling procedure using image processing, geographical information systems, and analytical photogrammetry is presented which can be used to guide the collection of representative, high-resolution spectra and discrete reflectance targets for future satellite sensors. The procedure is general and can be adapted to characterize areas as small as minor watersheds and as large as multistate regions. Beginning with a user-determined study area, successive reductions in size and spectral variation are performed using image analysis techniques on data from the Multispectral Scanner, orbital and simulated Thematic Mapper, low altitude photography synchronized with the simulator, and associated digital data. An integrated image-based geographical information system supports processing requirements.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
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  • 5
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    Spectral characterization of the LANDSAT-4 thematic mapper sensors (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: Data collected on the spectral characteristics of the LANDSAT-4 and LANDSAT-4 backup thematic mapper instruments, the protoflight (PF) and flight (F) models, respectively are analyzed and summarized. Tests were conducted on the instruments and their components to determine compliance with two sets of spectral specifications: Band-by-band spectral coverage and channel-by-channel within-band spectral matching.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: LANDSAT-4 Sci. Characterization; 2 p
    Format: text
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  • 6
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    Thermal band characterization of LANDSAT-4 thematic mapper (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: The TM band 6 shutter background and the 34.7 C internal black body signal were measured over 50 day dates. Variability of the shutter background temperature was from 7 C to 11 C. For ten specific images, the digital counts of the calibration data were measured. The average pulse value of the black body peak decreased from 174 to 149 counts while the shutter background counts varied as a function of shutter temperature from 77 to 85. Relative internal gains between the four channels were calculated and compared to prelaunch values. They showed gains over 9 months of up to 5%. Frequency histograms of number of pixels vs. digital counts from a night scene were used to determine gain relative to the mean and to discern a systematic along-scan pattern in a difference between forward and reverse scan counts of up to 0.5. A corrected digital image was obtained. A temperature estimate for and area of Lake Erie of 18.5 C to 19.9 C was obtained. Local temperature records showed 21 C.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: LANDSAT-4 Sci. Characterization; 3 p
    Format: text
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  • 7
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    TM report (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: Key spectral, radiometric, and geometric characteristics of the TM sensor are examined. Spectrally, band 5 is slightly wider than specified and its upper edge at 50% of miximum of 1784 nm includes some unintended overlap with water absorption bands. Thermal band 6 is half the expected width. Radiometrically, the TM has extreme linearity and stability in comparison with previous MSS photomultiplier systems. Forward and reverse scans on TM show some unexplained radiometric differences of up to four digital levels. Primary focal plane bands show a monotomic decrease in gain of about 5% in the five months since launch. The relative internal gains of bands 5 and 7 varied with a period of about 60 days and an amplitude of about 6%. Radiometric calibration must be applied before histogram equalization algorithms to preserve radiometric accuracy. Geometrically, channel 4 in band 2 has a smaller modulation transfer function than desired. There is apparent misregistration of .75 pixels along scan and 0.2 pixels across scan.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: LANDSAT-4 Sci. Characterization; 2 p
    Format: text
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  • 8
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    LANDSAT-4 evaluation program and scientific characterization activities (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: The characterization objectives of the LANDSAT 4 Science Office at GSFC are to: (1) determine the accuracy and precision of sensor and spacecraft performance, image data quality, and derived information; (2) recommend LANDSAT 4 system improvements; and (3) communicate results to the research community. In-house activities are directed toward full access and utilization of the prelaunch and in-orbit engineering test data on the sensor and spacecraft. Principle scientists in remote sensing are involved as part of a major scientific characterization effort, and workshops were held for these investigative teams. A symposium is scheduled prior to turnover of the TM to NOAA.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: LANDSAT-4 Sci. Characterization; 2 p
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  • 9
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    Spectral characterization of the Landsat-4 MSS sensors (1983)
    In:  Other Sources
    Details
    Publication Date: 2011-08-18
    Description: Two multispectral scanner subsystems (MSS) have been fabricated and tested by an American aerospace company for the NASA Landsat program. One MSS, designated the protoflight (PF) model, was integrated into the Landsat-4 spacecraft, which was launched on July 16, 1982. The second, designated the flight (F) model, has been integrated into the Landsat-4 backup satellite, which is scheduled for possible launch in 1985. Each MSS has four bands in the reflective portion of the electromagnetic spectrum. The engineering test data which were collected included channel-by-channel spectral response curves. A description of the test procedure is included in Appendix A. This document is to make available to the Landsat user community data on the spectral characteristics of the two sensors. The Landsat-4 PF and F scanners were found to be essentially identical in mean spectral response.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: Photogrammetric Engineering and Remote Sensing (ISSN 0099-1112); 49; June 198
    Format: text
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  • 10
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    Characterizing user requirements for future land observing satellites (1981)
    In:  CASI
    Details
    Publication Date: 2019-06-28
    Description: The objective procedure was developed for identifying probable sensor and mission characteristics for an operational satellite land observing system. Requirements were systematically compiled, quantified and scored by type of use, from surveys of federal, state, local and private communities. Incremental percent increases in expected value of data were estimated for critical system improvements. Comparisons with costs permitted selection of a probable sensor system, from a set of 11 options, with the following characteristics: 30 meter spatial resolution in 5 bands and 15 meters in 1 band, spectral bands nominally at Thematic Mapper (TM) bands 1 through 6 positions, and 2 day data turn around for receipt of imagery. Improvements are suggested for both the form of questions and the procedures for analysis of future surveys in order to provide a more quantitatively precise definition of sensor and mission requirements.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: NASA-TM-83867
    Format: application/pdf
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