Publication Date:
1982-08-20
Description:
Serum and epidermal concentrations of 8-methoxypsoralen and 5-methoxypsoralen 2 hours after oral administration to guinea pigs were determined by high-performance liquid chromatography. A linear relation was found between the serum and epidermal concentrations of 8-methoxypsoralen. In addition, a relation was found between serum concentrations of 5-methoxypsoralen and 8-methoxypsoralen and the appearance of phototoxicity. The lower phototoxicity of orally administered 5-methoxypsoralen as compared to 8-methoxypsoralen in the guinea pig appears to be due to its reduced concentrations in the epidermis, the primary site of the phototoxic events.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kornhauser, A -- Wamer, W G -- Giles, A L Jr -- New York, N.Y. -- Science. 1982 Aug 20;217(4561):733-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7100920" target="_blank"〉PubMed〈/a〉
Keywords:
Administration, Oral
;
Administration, Topical
;
Animals
;
Epidermis/*analysis
;
Guinea Pigs
;
Methoxsalen/administration & dosage/*analysis/blood
;
Photosensitivity Disorders/*etiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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