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  • Articles  (2)
  • Bone resorption  (2)
  • 1980-1984  (2)
  • 1980  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of prostaglandin E2 on macrophages and osteoclasts in cultured fetal long bones (1980)
    Springer
    Cell & tissue research 207 (1980), S. 341-346 
    Details
    ISSN: 1432-0878
    Keywords: Macrophage ; Osteoclast ; Prostaglandin ; Bone resorption ; Organ culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Bone cultures exposed to prostaglandin E2 (PGE2) revealed an increase in 45Ca release from bone to medium and an increase in osteoclast number compared to control bones. In addition, PGE2-treated osteoclasts contained a more extensive ruffled border region than control osteoclasts. These data suggest that PGE2 activates existing osteoclasts and causes proliferation and differentiation of osteoclast precursor cells. The existence of macrophages in resorbing fetal bone explants was documented. These macrophages contain numerous phagolysosomes and lipid vacuoles and are often located adjacent to osteoclasts or closely apposed to calcified tissue surfaces. PGE2 caused an early increase in the number of macrophages. It is postulated that fetal bone macrophages are primarily engaged in phagocytosis and digestion of cellular debris, but also play a role in the process of bone resorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00237817
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  • 2
    Electronic Resource
    Electronic Resource
    Osteoid resorption by mononuclear cells in vitro (1980)
    Springer
    Cell & tissue research 210 (1980), S. 493-500 
    Details
    ISSN: 1432-0878
    Keywords: Mononuclear cell ; Organ culture ; Osteoid ; Bone resorption ; Macrophage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary For the first time, mononuclear cell-mediated ingestion of osteoid in cultures of long bones of fetal rats is described and characterized. The mononuclear cells, located at sites of osteoid deposition, ingest collagen fibrils and clumps of mineral crystals which are segregated within cytoplasmic vacuoles or multivesicular bodies. The ingestion of osteoid continues in cultures treated with agents that normally inhibit osteoclastic bone resorption. Morphologically, the osteoid-containing cells are characterized by a moderate number of mitochondria and short-stranded rough endoplasmic reticulum, a modest Golgi apparatus and variable numbers of vesicles, vacuoles, and multivesicular bodies. The morphologic appearance of the mononuclear cell is consistent with that of a macrophage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00220205
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    Paper (German National Licenses)
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