ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Enhancement of Detection Sensitivity of Cyclosporin A by Derivatization with 2-NapthylselenylchlorideThe UV./HPLC. detection sensitivity of cyclosporine A 1, an immunosuppressive cyclic undecapeptide containing one D-aminoacid and seven N-methylated aminoacids, is enhanced by a factor of 3-4 (limit of detection 5 ng) by conversion of the characteristic side chain of amino-acid-1 to the β-naphthylseleno-substituted tetrahydrofuran derivative 4.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19800630323
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