ISSN:
1573-8744
Keywords:
Sulfonamides
;
absorption rate constants
;
reverse-phase partition chromatography
;
Wagner-Sedman extraction theory
;
absorption from the small intestine
;
logarithmiclogistic correlations
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The chromatographic parameters in a reverse-phase partition system and the rat gut in situabsorption rate constants for 18 antibacterial sulfonamides are highly correlated values. The correlation is logarithmic-logistic in nature, being in accordance with the Wagner-Sedman extraction theory for a constant pH value. Parabolic correlations did not satisfactorily fit the experimental data. This behavior, not frequently reported in regard to the intestinal absorption of drugs, is discussed in connection with other apparently contradictory available data.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01059647
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