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Effect of pH on the calcium metabolism of isolated rat kidney cells (1979)

Studer, Rebecca K. ; Borle, André B.

Springer

The journal of membrane biology 48 (1979), S. 325-341

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ISSN: 1432-1424

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Summary The effects of metabolic and respiratory acidosis and alkalosis on cellular calcium metabolism were studied in rat kidney cells dispersed with collagenase. In both types of acidosis, the intracellular pH, total cell calcium, and the cell relative radioactivity after 60 min of labeling are significantly depressed. Kinetic analysis of45Ca desaturation curves shows that acidosis decreases all three cellular calcium pools and depresses calcium fluxes between the superficial and cytosolic pools and between the cytosolic and mitochondrial pools. In alkalosis the intracelluar pH, the total cell calcium, and the cell relative radioactivity are significantly increased. Kinetic studies show that in alkalosis, only the mitochondrial pool is consistently increased. Calcium exchange between the mitochondrial and cytosolic pool is increased in metabolic alkalosis only. These results suggest that hydrogen ion is an important modulator of calcium metabolism, and that the intracellular pH rather than extracellular pH is the critical factor in determining the calcium status of cells during altered acid-base conditions.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01869444

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Knowledge and structures of scientific growth measurement of a cancer problem domain (1979)

Chubin, D. E. ; Studer, K. E.

Springer

Scientometrics 1 (1979), S. 171-193

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ISSN: 1588-2861

Source: Springer Online Journal Archives 1860-2000

Topics: Information Science and Librarianship , Nature of Science, Research, Systems of Higher Education, Museum Science

Notes: Abstract In the context of bridging the so-called externalist and cognitive perspectives on the growth of research communities, a cancer “problem domain” is examined (1) to distinguish a growth in knowledge from a proliferating research literature, and (2) show how measurement of formal communication, uninformed by the “historical record,” clarifies or distorts sociological interpretations of innovation and growth in biomedicine. Specifically, coauthorship and citation networks are analyzed for reverse transcriptase researchers, 1970–74. This analysis reveals the visibility of large National Cancer Institute laboratories in the research literature, but demonstrates the need to augment disaggregated network data with intellectual and social (policy) history to explain the growth and structure of the domain.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02016969

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