ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Hanover, NH : U.S. Army Cold Regions Research and Engineering Laboratory  (2)
  • American Society of Hematology  (1)
  • 2000-2004  (1)
  • 1995-1999
  • 1975-1979  (2)
  • 2004  (1)
  • 1979  (2)
Collection
Publisher
Language
Years
  • 2000-2004  (1)
  • 1995-1999
  • 1975-1979  (2)
Year
  • 2004  (1)
  • 1979  (2)
  • 2000  (2)
  • 1
    Series available for loan
    Series available for loan
    Hanover, NH : U.S. Army Cold Regions Research and Engineering Laboratory
    Associated volumes
    Call number: ZSP-201-79/29
    In: CRREL Report, 79-29
    Description / Table of Contents: An analytical study of the propagation of shock waves in snow was carried out to evaluate the response of medium density snow to high rates of loading. One solution was developed for steady shock waves; this resulted in calculation of pressure jump, density jump and stress wave speed. Correlation with available experimental data was found to be good. Nonsteady shock waves were also considered in order to evaluate wave attenuation rates in snow. Very few data were available to compare with the analytical results, so no definite conclusions on the part of the study could be made. The results show, however, that shock waves that produce plastic deformation attenuate at extremely high rates and that differences in pressure between two waves are quickly eliminated within a short distance. Calculations were also made to evaluate the effect of wave frequency on attenuation rates. The results show that, for plastic waves, frequency is not a predominant factor for determining attenuation rates.
    Type of Medium: Series available for loan
    Pages: v, 14 Seiten , Illustrationen
    Series Statement: CRREL Report 79-29
    Language: English
    Note: CONTENTS Abstract Preface Nomenclature I. Introduction II. A constitutive law for snow and balance principles III. Compatibility laws and jump equations for stress waves IV. Steady shock waves in snow V. Comparison of steady-wave theory with experimental results VI. A numerical solution to the nonsteady wave problem VII. Jump equations for nonsteady shock waves VIII. Reduced jump equations Discussion and conclusions Literature cited
    Location: AWI Archive
    Branch Library: AWI Library
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Series available for loan
    Series available for loan
    Hanover, NH : U.S. Army Cold Regions Research and Engineering Laboratory
    Associated volumes
    Call number: ZSP-201-79/20
    In: CRREL Report, 79-20
    Description / Table of Contents: A volumetric constitutive equation was developed to characterize the behavior of snow subjected to large compressive volumetric deformations. By treating the material as a suspension of air voids in a matrix material of polycrystalline ice, a rate-dependent volumetric constitutive law was formulated and found to accurately predict material response to pressure loads for a wide range of load rates. Comparison of the theory with shock wave data was not considered in this paper, although the constitutive law appears to be valid for such load situations. One application to oversnow mobility of tracked vehicles was made. In this case, power requirements due to snow compaction were calculated parametrically in terms of vehicle speed, track loading, and snow density.
    Type of Medium: Series available for loan
    Pages: v, 13 Seiten , Illustrationen
    Series Statement: CRREL Report 79-20
    Language: English
    Note: CONTENTS Abstract Preface Nomenclature Introduction Material representation of ice Development of the volumetric constitutive law for snow Fully elastic phase Elastic-plastic phase Fully plastic phase Simplified equation Comparison with experimental data Application to vehicle mobility problems Conclusions Literature cited
    Location: AWI Archive
    Branch Library: AWI Library
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2004-11-16
    Description: Hox (homeobox) genes are known to be key regulators of development and haematopoiesis and several have also been implicated in leukaemogenesis. Overexpression of HoxA5 in human haematopoietic progenitors leads to an increase in myelopoiesis, suggesting a role for this hox gene during induction of myeloid differentiation. Inactivation of genes by CpG island DNA methylation is known to be important in the development and progression of leukaemia, and inhibitors of DNA methylation are currently of great interest as novel therapeutics for a number of haematopoietic malignancies. Here we show that in peripheral blood from healthy volunteers HoxA5 exhibits methylation of 50% of alleles across an extensive CpG island covering the promoter region/1st exon of HoxA5. In patients with chronic myeloid leukaemia, 33% (15/45 patients) exhibited increased methylation of HoxA5 (80–100% of alleles methylated) in the chronic phase of the disease. However, such hypermethylation of HoxA5 was invariably present in samples from patients in myeloid blast crisis (15/15 patients). In contrast, patients in lymphoid blast crisis did not exhibit increased levels of hypermethylation. Analysis of patients in chronic phase demonstrated a statistically significant correlation (p 〈 0.006) between hypermethylation of the HoxA5 gene and other prognostic factors associated with high risk of progression to blast crisis (high Hasford/Sokal score, incomplete response to Imatinib, known early progression, del 9), suggesting that methylation of HoxA5 may be a clinically useful prognostic indicator. The results are also compatible with a direct role for hypermethylation of HoxA5, and consequent loss of HoxA5 expression, in inhibition of myeloid differentiation during progression to blast crisis and implicate HoxA5 as a therapeutic target for inhibitors of DNA methylation in the treatment of leukaemia.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...