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Optical Resolution Photoacoustic Microscopy of Ovary and Fallopian Tube (2019)

Rao, Bin ; Leng, Xiandong ; Zeng, Yifeng ; [weitere]

Springer Nature

In: Scientific Reports. 2019; 9(1): 14306. Published 2019 Oct 04. doi: 10.1038/s41598-019-50743-7.

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Publikationsdatum: 2019-10-04

Beschreibung: Ovarian cancer is the leading cause of death among gynecological cancers, but is poorly amenable to preoperative diagnosis. In this study, we investigate the feasibility of “optical biopsy,” using high-optical-resolution photoacoustic microscopy (OR-PAM) to quantify the microvasculature of ovarian and fallopian tube tissue. The technique is demonstrated using excised human ovary and fallopian tube specimens imaged immediately after surgery. Quantitative parameters are derived using Amira software. The parameters include three-dimensional vascular segment count, total volume and length, which are associated with tumor angiogenesis. Qualitative results of OR-PAM demonstrate that malignant ovarian tissue has larger and more tortuous blood vessels as well as smaller vessels of different sizes, while benign and normal ovarian tissue has smaller vessels of uniform size. Quantitative analysis shows that malignant ovaries have greater tumor vessel volume, length and number of segments, as compared with benign and normal ovaries. The vascular pattern of benign fallopian tube is different than that of benign ovarian tissue. Our initial results demonstrate the potential of OR-PAM as an imaging tool for fast assessment of ovarian tissue and fallopian tube and could avoid unnecessary surgery if the risk of the examined ovary is extremely low.

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Management and Environment Effects on Brassica Forage Quality (1994)

Wiedenhoeft, M. Hagemann ; Barton, B. A.

Wiley

In: Agronomy Journal. 1994; 86(2): 227-232. Published 1994 Mar 01. doi: 10.2134/agronj1994.00021962008600020003x.

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Publikationsdatum: 1994-03-01

Print ISSN: 0002-1962

Digitale ISSN: 1435-0645

Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft

Publiziert von Wiley

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Does soil aging affect the N2O mitigation potential of biochar? A combined microcosm and field study (2016)

Nikolas Hagemann, Johannes Harter, Radina Kaldamukova, Ivan Guzman-Bustamante, Reiner Ruser, Simone Graeff, Andreas Kappler, Sebastian Behrens

Wiley

In: GCB Bioenergy

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Publikationsdatum: 2016-07-21

Beschreibung: The application of biochar as a soil amendment to improve soil fertility has been suggested as a tool to reduce soil-borne CO 2 and non-CO 2 greenhouse gas emissions, especially nitrous oxide (N 2 O). Both lab and field trials have demonstrated N 2 O emission reduction by biochar amendment, but the long-term effect (〉1 year) has been questioned. Here we present results of a combined microcosm and field study using a powdered beech wood biochar from slow pyrolysis. The field experiment showed that both CO 2 and N 2 O emissions were still effectively reduced by biochar in the third year after application. However, biochar did not influence the biomass yield of sunflower for biogas production ( Helianthus annuus L.). Biochar reduced bulk density and increased soil aeration and thus reduced the water filled pore space (WFPS) in the field, but was also able to suppress N 2 O emission in the microcosms experiment conducted at constant WFPS. For both experiments, biochar had limited impact on soil mineral nitrogen speciation, but it reduced the accumulation of nitrite in the microcosms. Extraction of soil DNA and quantification of functional marker genes by qPCR showed that biochar did not alter the abundance of nitrogen-transforming bacteria and archaea in both field and microcosm experiments. In contradiction to previous experiments, this study demonstrates the long-term N 2 O emission suppression potential of a wood biochar and thus highlights its overall climate change mitigation potential. While a detailed understanding of the underlying mechanisms requires further research we provide evidence for a range of biochar-induced changes to the soil environment and their change with time that might explain the often observed N 2 O emission suppression. This article is protected by copyright. All rights reserved.

Print ISSN: 1757-1693

Digitale ISSN: 1757-1707

Thema: Energietechnik

Publiziert von Wiley

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Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer (2016)

Khaled Ali; Dalya R. Soond; Roberto Piñeiro; Thorsten Hagemann; Wayne Pearce; Ee Lyn Lim; Hicham Bouabe; Cheryl L. Scudamore; Timothy Hancox; Heather Maecker; Lori Friedman; Martin Turner; Klaus Okkenhaug; Bart Vanhaesebroeck

Springer Nature

In: Nature

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Publikationsdatum: 2016-07-28

Beschreibung: Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer Nature 535, 7613 (2016). doi:10.1038/nature17641 Authors: Khaled Ali, Dalya R. Soond, Roberto Piñeiro, Thorsten Hagemann, Wayne Pearce, Ee Lyn Lim, Hicham Bouabe, Cheryl L. Scudamore, Timothy Hancox, Heather Maecker, Lori Friedman, Martin Turner, Klaus Okkenhaug & Bart Vanhaesebroeck Nature510, 407–411 (2014); doi:10.1038/nature13444Queen Mary University London notified Nature and University College London that there is reason to question the provenance of the data for Fig. 5b, d, e of this Letter (Fig. 5a, c

Print ISSN: 0028-0836

Digitale ISSN: 1476-4687

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Asian Irrigation, African Rain: Remote Impacts of Irrigation (2016)

Philipp Vrese, Stefan Hagemann, Martin Claussen

Wiley

In: Geophysical Research Letters

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Publikationsdatum: 2016-03-10

Beschreibung: Irrigation is not only vital for global food security, but also constitutes an anthropogenic land-use change, known to have strong effects on local hydrological and energy cycles. Using the Max Planck Institute for Meteorology's Earth System Model we show that related impacts are not confined regionally, but that possibly as much as 40% of the present-day precipitation in some of the arid regions in Eastern Africa are related to irrigation-based agriculture in Asia. Irrigation in South Asia also substantially influences the climate throughout Southeast Asia and China via the advection of water vapor and by altering the Asian monsoon. The simulated impact of irrigation on remote regions is sensitive to the magnitude of the irrigation-induced moisture flux. Therefore, it is likely that a future extension or decline of irrigated areas due to increasing food demand or declining fresh water resources will also affect precipitation and temperatures in remote regions.

Print ISSN: 0094-8276

Digitale ISSN: 1944-8007

Thema: Geologie und Paläontologie , Physik

Publiziert von Wiley im Namen von American Geophysical Union (AGU).

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Genomic encoding of transcriptional burst kinetics (2019)

Anton J. M. Larsson, Per Johnsson, Michael Hagemann-Jensen, Leonard Hartmanis, Omid R. Faridani, Björn Reinius, Åsa Segerstolpe, Chloe M. Rivera, Bing Ren, Rickard Sandberg

Springer Nature

In: Nature

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Publikationsdatum: 2019

Print ISSN: 0028-0836

Digitale ISSN: 1476-4687

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Land–atmosphere feedbacks amplify aridity increase over land under global warming (2016)

Alexis Berg; Kirsten Findell; Benjamin Lintner; Alessandra Giannini; Sonia I. Seneviratne; Bart van den Hurk; Ruth Lorenz; Andy Pitman; Stefan Hagemann; Arndt Meier; Frédérique Cheruy; Agnès Ducharne; Sergey Malyshev; P. C. D. Milly

Springer Nature

In: Nature Climate Change

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Publikationsdatum: 2016-08-26

Beschreibung: Aridity is expected to increase globally in a warmer world. Research now suggests that this is substantially amplified by land–atmosphere feedbacks associated with the land surface’s response to climate and plant responses to increased atmospheric CO2. Nature Climate Change 6 869 doi: 10.1038/nclimate3029

Print ISSN: 1758-678X

Digitale ISSN: 1758-6798

Thema: Geologie und Paläontologie

Publiziert von Springer Nature

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Influence of land-atmosphere feedbacks on temperature and precipitation extremes in the GLACE-CMIP5 ensemble (2015)

Ruth Lorenz, Daniel Argüeso, Markus G. Donat, Andrew J. Pitman, Bart van den Hurk, Alexis Berg, David M. Lawrence, Frédérique Chéruy, Agnès Ducharne, Stefan Hagemann, Arndt Meier, P. C. D. Milly, Sonia I. Seneviratne

Wiley

In: Journal of Geophysical Research JGR - Atmospheres

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Publikationsdatum: 2015-12-17

Beschreibung: We examine how soil moisture variability and trends affect the simulation of temperature and precipitation extremes in six global climate models using the experimental protocol of the Global Land-Atmosphere Coupling Experiment of the Coupled Model Intercomparison Project, Phase 5 (GLACE-CMIP5). This protocol enables separate examinations of the influences of soil moisture variability and trends on the intensity, frequency and duration of climate extremes through to the end of the 21 s t century under a business-as-usual (RCP8.5) emission scenario. Removing soil moisture variability significantly reduces temperature extremes over most continental surfaces while wet precipitation extremes are enhanced in the tropics. Projected drying trends in soil moisture lead to increases in intensity, frequency, and duration of temperature extremes by the end of the 21 s t century. Wet precipitation extremes are decreased in the tropics with soil moisture trends in the simulations while dry extremes are enhanced in some regions, in particular the Mediterranean and Australia. However, the ensemble results mask considerable differences in the soil moisture trends simulated by the six climate models. We find that the large differences between the models in soil moisture trends, which are related to an unknown combination of differences in atmospheric forcing (precipitation, net radiation), flux partitioning at the land surface, and how soil moisture is parameterized, imply considerable uncertainty in future changes in climate extremes.

Print ISSN: 0148-0227

Thema: Geologie und Paläontologie , Physik

Publiziert von Wiley im Namen von American Geophysical Union (AGU).

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ADAM8 as a drug target in pancreatic cancer (2015)

Uwe Schlomann; Garrit Koller; Catharina Conrad; Taheera Ferdous; Panagiota Golfi; Adolfo Molejon Garcia; Sabrina Höfling; Maddy Parsons; Patricia Costa; Robin Soper; Maud Bossard; Thorsten Hagemann; Rozita Roshani; Norbert Sewald; Randal R. Ketchem; Marcia L. Moss; Fred H. Rasmussen; Miles A. Miller; Douglas A. Lauffenburger; David A. Tuveson; Christopher Nimsky; Jörg W. Bartsch

Springer Nature

In: Nature Communications

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Publikationsdatum: 2015-01-30

Beschreibung: Article Expression of ADAM8, a metalloprotease disintegrin, correlates with worse prognosis in pancreatic adenocarcinoma (PDAC). Here Schlomann et al . show that ADAM8 promotes PDAC invasiveness, and develop a peptide inhibitor that blocks ADAM8 function and impedes PDAC progression in mouse models. Nature Communications doi: 10.1038/ncomms7175 Authors: Uwe Schlomann, Garrit Koller, Catharina Conrad, Taheera Ferdous, Panagiota Golfi, Adolfo Molejon Garcia, Sabrina Höfling, Maddy Parsons, Patricia Costa, Robin Soper, Maud Bossard, Thorsten Hagemann, Rozita Roshani, Norbert Sewald, Randal R. Ketchem, Marcia L. Moss, Fred H. Rasmussen, Miles A. Miller, Douglas A. Lauffenburger, David A. Tuveson, Christopher Nimsky, Jörg W. Bartsch

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Regionally coupled atmosphere-ocean- sea ice-marine biogeochemistry model ROM: 1. Description and validation (2015)

Dmitry V. Sein, Uwe Mikolajewicz, Matthias Gröger, Irina Fast, William Cabos, Joaquim G. Pinto, Stefan Hagemann, Tido Semmler, Alfredo Izquierdo, Daniela Jacob

Wiley

In: Journal of Advances in Modeling Earth Systems

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Publikationsdatum: 2015-02-12

Beschreibung: The general circulation models used to simulate global climate typically feature resolution too coarse to reproduce many smaller scale processes, which are crucial to determining the regional responses to climate change. A novel approach to downscale climate change scenarios is presented which includes the interactions between the North Atlantic Ocean and the European shelves as well as their impact on the North Atlantic and European climate. The goal of this paper is to introduce the global ocean – regional atmosphere coupling concept and to show the potential benefits of this model system to simulate present day climate. A global ocean – sea ice – marine biogeochemistry model (MPIOM/HAMOCC) with regionally high horizontal resolution is coupled to an atmospheric regional model (REMO) and global terrestrial hydrology model (HD) via the OASIS coupler. Moreover, results obtained with ROM using NCEP/NCAR reanalysis and ECHAM5/MPIOM CMIP3 historical simulations as boundary conditions are presented and discussed for the North Atlantic and North European region. The validation of all the model components, i.e. ocean, atmosphere, terrestrial hydrology and ocean biogeochemistry is performed and discussed. The careful and detailed validation of ROM provides evidence that the proposed model system improves the simulation of many aspects of the regional climate, remarkably the ocean, even though some biases persist in other model components, thus leaving potential for future improvement. We conclude that ROM is a powerful tool to estimate possible impacts of climate change on the regional scale. This article is protected by copyright. All rights reserved.

Digitale ISSN: 1942-2466

Thema: Geographie , Geologie und Paläontologie

Publiziert von Wiley im Namen von American Geophysical Union (AGU).

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