Publikationsdatum:
1978-12-22
Beschreibung:
Long-term treatment of rats with clinically effective tricyclic antidepressant drugs induced a selective increase in the inhibitory response of forebrain neurons to serotonin applied by microiontophoresis. Long-term administration of some related drugs which lack antidepressant efficacy failed to induce such a change. The enhanced response to serotonin induced by the clinically active tricyclic drugs took 1 to 2 weeks to develop, a time course which correlates with the delayed onset of therapeutic effects in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Montigny, C -- Aghajanian, G K -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1303-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725608" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Action Potentials/drug effects
;
Animals
;
Antidepressive Agents, Tricyclic/*pharmacology
;
Decerebrate State
;
Drug Synergism
;
Geniculate Bodies/*drug effects
;
Hippocampus/*drug effects
;
Male
;
Neural Inhibition/drug effects
;
Norepinephrine/pharmacology
;
Pyramidal Tracts/drug effects
;
Rats
;
Receptors, Serotonin/*drug effects
;
Serotonin/*pharmacology
;
gamma-Aminobutyric Acid/pharmacology
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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