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  • Humans  (48)
  • Rats  (25)
  • American Association for the Advancement of Science (AAAS)  (68)
  • American Chemical Society
  • 1980-1984
  • 1975-1979  (68)
  • 1978  (68)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (68)
  • American Chemical Society
Years
  • 1980-1984
  • 1975-1979  (68)
Year
  • 1
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    Thrombin-induced platelet aggregation is mediated by a platelet plasma membrane-bound lectin (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-16
    Description: Throbin-activated human platelets cause agglutination of trypsinized, formalinized bovine erythrocytes. This lectin activity of stimulated platelets was blocked by galactosamine, glucosamine, mannosamine, lysine, and arginine, but not by N-acetylated sugars, other neutral sugars, or other amino acids. Inhibitors of the thrombin-induced lectin activity also blocked thrombin-induced platelet aggregation. It appears that a membrane surface component that has lectin activity mediates platelet aggregation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gartner, T K -- Williams, D C -- Minion, F C -- Phillips, D R -- New York, N.Y. -- Science. 1978 Jun 16;200(4347):1281-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663608" target="_blank"〉PubMed〈/a〉
    Keywords: *Agglutinins ; Amino Acids/pharmacology ; Amino Sugars/pharmacology ; Animals ; Binding Sites ; Cytochalasin B/pharmacology ; *Hemagglutinins ; Humans ; Membrane Proteins/blood ; Platelet Aggregation/*drug effects ; Prostaglandins E/pharmacology ; Species Specificity ; Thrombin/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Ethics and the use of drugs during pregnancy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sabath, L D -- Philipson, A -- Charles, D -- New York, N.Y. -- Science. 1978 Nov 3;202(4367):540-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/705345" target="_blank"〉PubMed〈/a〉
    Keywords: Aborted Fetus ; Ampicillin/blood ; Anti-Bacterial Agents/administration & dosage ; *Ethics, Medical ; Female ; Humans ; Informed Consent ; Maternal-Fetal Exchange ; Pregnancy/*drug effects ; *Pregnant Women
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Fluorinated molecule as a tracer: difluoroserotonin in human platelets mapped by electron energy-loss spectroscopy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: The intracellular distribution of fluorine has been delineated in human platelets incubated with 4,6-difluoroserotonin, utilizing a scanning-transmission electron microscope equipped with an energy-loss spectrometer. Discrete intracellular structures corresponding in location to dense bodies contained high concentrations of fluorine. Electron energy-loss spectroscopy, which apparently can detect less than 10(-20) gram of fluorine in an area of 10 square nonometers, can thus localize fluorinated tracer molecules with biological activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Costa, J L -- Joy, D C -- Maher, D M -- Kirk, K L -- Hui, S W -- New York, N.Y. -- Science. 1978 May 5;200(4341):537-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644312" target="_blank"〉PubMed〈/a〉
    Keywords: Blood Platelets/*metabolism ; Energy Transfer ; *Fluorine ; Humans ; Microscopy, Electron/methods ; Serotonin/*analogs & derivatives/blood ; Spectrum Analysis/methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Infantile stimulation induces brain lateralization in rats (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: The hypothesis tested was that the effects of early experiences are asymmetrically distributed in the two brain hemispheres. Litters were either handled or not handled between birth and weaning, and the weanlings were reared in either laboratory cages or enriched environments between 21 and 50 days. When approximately 135 days old, animals within each of the four treatment groups had a right neocortical ablation, a left neocortical ablation, a sham operation, or no surgery. About 1 month later, all animals were given the open-field test for emotionality and exploratory behavior. Ablating either the right or left neocortex increased the activity scores of nonhandled controls, but there was no evidence of lateralization. However, the groups handled in infancy did show lateralization. Ablating the left brain did not significantly increase activity, but ablating the right brain caused extreme scores: handled rats without enrichment experience were the most active, and handled rats also placed into the enriched environment had near-zero scores in the open field.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Denenberg, V H -- Garbanati, J -- Sherman, D A -- Yutzey, D A -- Kaplan, R -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1150-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684436" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn/*physiology ; Brain/*physiology ; Cerebral Cortex/physiology ; Emotions/physiology ; *Environment ; Exploratory Behavior/physiology ; Female ; Functional Laterality/*physiology ; Handling (Psychology)/*physiology ; Male ; Motor Activity/physiology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Enkephalin-like material elevated in ventricular cerebrospinal fluid of pain patients after analgetic focal stimulation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-04
    Description: Enkephalin-like activity has been measured in the ventricular cerebrospinal fluid of patients with intractable pain. Electrical stimulation of periventricular brain sites resulted in significant decrease in persistent pain in these subjects. This analgesia, which was blocked by naloxone in 80% of the cases, was accompanied by a significant rise in ventricular enkephalin-like activity, as measured by two different methods. The results present evidence of in vivo release of enkephalin-like material in humans and suggest that stimulation analgesia may be partially due to this release.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Akil, H -- Richardson, D E -- Hughes, J -- Barchas, J D -- New York, N.Y. -- Science. 1978 Aug 4;201(4354):463-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663668" target="_blank"〉PubMed〈/a〉
    Keywords: Brain/*physiopathology ; Cerebral Aqueduct ; Electric Stimulation ; Endorphins/*cerebrospinal fluid ; Enkephalins/*cerebrospinal fluid ; Female ; Humans ; Male ; Pain/*cerebrospinal fluid/physiopathology ; Pain Management
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Children absorb tris-BP flame retardant from sleepwear: urine contains the mutagenic metabolite, 2,3-dibromopropanol (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: The flame retardant, tris(2,3-dibromopropyl)phosphate (tris-BP), which is a mutagen and causes cancer and sterility in animals is absorbed from fabric by people. 2,3-Dibromopropanol, a metboloite of tris-BP and a mutagen itself, has been found in the urine samples of ten children who were wearing or who had worn tris-BP-treated sleepwear. Eight of these children were wearing well-washed sleepwear and the possibility of absorption of tris-BP from well-washed sleepwear discussed. 2,3-Dibromopropanol was not found in the urines of one child and one adult who had never worn tris-BP-treated garments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blum, A -- Gold, M D -- Ames, B N -- Jones, F R -- Hett, E A -- Dougherty, R C -- Horning, E C -- Dzidic, I -- Carroll, D I -- Stillwell, R N -- Thenot, J P -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):1020-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684422" target="_blank"〉PubMed〈/a〉
    Keywords: 1-Propanol/urine ; Child ; Chromatography, Gas ; *Clothing ; Female ; Flame Retardants/*metabolism ; Humans ; Hydrocarbons, Brominated/metabolism ; Mass Spectrometry/methods ; Mutagens/*metabolism ; Organophosphates/*metabolism ; *Propanols ; *Skin Absorption
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Striatal nondopaminergic neurons: possible involvement in feeding and drinking behavior (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-09
    Description: Intracaudate injections of kainic acid destroy striatal neurons containing acetylcholine and gamma-aminobutyric acid but leave dopaminergic nerve terminals in this brain region intact. Rats injected with the drug are aphagic and adipsic, and have other behavioral abnormalities strikingly similar to those seen in animals with lesions in the dopaminergic nigrostriatal bundle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pettibone, D J -- Kaufman, N -- Scally, M C -- Meyer, E Jr -- Ulus, I -- Lytle, L D -- New York, N.Y. -- Science. 1978 Jun 9;200(4346):1175-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653362" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal/drug effects ; Caudate Nucleus/*drug effects/physiology ; Choline O-Acetyltransferase/metabolism ; Dopamine/metabolism ; Dose-Response Relationship, Drug ; Drinking Behavior/*drug effects ; Feeding Behavior/*drug effects ; Glutamate Decarboxylase/metabolism ; Kainic Acid/*pharmacology ; Male ; Posture ; Pyrrolidines/*pharmacology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Tricyclic antidepressants: therapeutic properties and affinity for alpha-noradrenergic receptor binding sites in the brain (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-13
    Description: Tricyclic antidepressants vary in their capacity to cause psychomotor activation, to relieve agitated depressive states, and to cause sedation and hypotension. We have quantified relative potencies of tricyclic antidepressants in competing for the binding of 3H-labeled WB-4101 to alpha-noradrenergic receptor sites in rat brain membranes. Affinities of tricyclic drugs for alpha-noradrenergic receptor sites in the brain correlate well with the capacity of these agents to relieve psychomotor agitation and to induce sedation and hypotension; these affinities also correlate inversely with tendencies to elicit psychomotor activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉U'Prichard, D C -- Greenberg, D A -- Sheehan, P P -- Snyder, S H -- New York, N.Y. -- Science. 1978 Jan 13;199(4325):197-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/202024" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antidepressive Agents, Tricyclic/*metabolism/therapeutic use ; Binding, Competitive ; Brain/*metabolism ; Humans ; Hypotension/chemically induced ; Psychomotor Agitation/*drug therapy ; Rats ; Receptors, Adrenergic/*metabolism ; Receptors, Adrenergic, alpha/*metabolism ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Choline administration: modification of the central actions of atropine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-06
    Description: The anticholinergic agent atropine decreases acetylcholine concentrations and increases high-affinity choline uptake in cortical and hippocampal regions of rat brain. Administration of choline 1 hour before atropine prevents both of these atropine-induced alterations. These findings suggest that alterations in acetylcholine precursor availability may modify the effects of centrally active anticholinergic agents.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wecker, L -- Dettbarn, W D -- Schmidt, D E -- New York, N.Y. -- Science. 1978 Jan 6;199(4324):86-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17569493" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylcholine/*metabolism ; Animals ; Atropine/*pharmacology ; Biological Transport/drug effects ; Choline/*administration & dosage/*metabolism/pharmacology ; Cholinergic Antagonists/pharmacology ; Hippocampus/drug effects/*metabolism ; Male ; Mesencephalon/drug effects/*metabolism ; Rats ; Rats, Sprague-Dawley ; Sodium/metabolism ; Synaptosomes/drug effects/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Nitrite and nitrate are formed by endogenous synthesis in the human intestine (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-30
    Description: Studies of nitrate balance in humans and analyses of fecal and ileostomy samples indicate that nitrite and nitrate are formed de novo in the intestine, possibly by heterotrophic nitrification. These findings significantly alter our previous conceptions of human exposure to nitrite and suggest an even wider role for nitrite in the etiology of human cancer.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tannenbaum, S R -- Fett, D -- Young, V R -- Land, P D -- Bruce, W R -- New York, N.Y. -- Science. 1978 Jun 30;200(4349):1487-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663630" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Dietary Proteins/metabolism ; Feces/metabolism ; Humans ; Ileostomy ; Intestines/*metabolism ; Male ; Nitrates/*metabolism/urine ; Nitrites/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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