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  • AEROSPACE MEDICINE  (1)
  • Chemistry  (1)
  • Drug Resistance  (1)
  • Enzyme digestion  (1)
  • 1975-1979  (4)
  • 1978  (2)
  • 1977  (2)
  • 1
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    Enhanced dexamethasone resistance in cystic fibrosis cells: potential use for heterozygote detection and prenatal diagnosis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: Cultured skin fibroblasts from patients with cystic fibrosis (CF) are more resistant to dexamethasone toxicity than are normal cells. We now report that, when fibroblasts cultured from obligate CF heterozygotes are exposed to dexamethasone, they have an intermediate survival compared to normal and homozygous CF cells. When dexamethasone survival was tested on cells from four patients undergoing amniocentesis, cells from a woman at risk of producing a child with CF showed significant dexamethasone resistance, similar to that of fibroblasts derived from lnown CF homozygotes; the other amniotic cell specimens showed dexamethasone sensitivity similar to that of normal skin fibroblasts. These data suggest that the dexamethasone resistance previously observed in skin fibroblasts may also be useful in the prenatal diagnosis of CF.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Breslow, J L -- Epstein, J -- Fontaine, J H -- Forbes, G B -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):180-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663650" target="_blank"〉PubMed〈/a〉
    Keywords: Amniotic Fluid/cytology ; Cell Survival/drug effects ; Cystic Fibrosis/diagnosis/genetics/*physiopathology ; Dexamethasone/*toxicity ; Drug Resistance ; Female ; Heterozygote ; Homozygote ; Humans ; Pregnancy ; Prenatal Diagnosis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Effect of prolonged space flight on cardiac function and dimensions (1977)
    In:  CASI
    Details
    Publication Date: 2006-01-16
    Description: By taking advantage of the capabilities of echocardiography to measure noninvasively left ventricular volume, stroke volume, and ejection fraction, and of the fact that the astronauts were routinely subjected to lower body negative pressure (whereby cardiac filling is progressively decreased), it was possible to construct classic ventricular function curves noninvasively, thereby obviating the difficulties encountered in comparing cardiac function at different end-diastolic volumes preflight and postflight. In this manner, the effect of an 84-day period of weightlessness on cardiac structure and function was evaluated in the Skylab 4 astronauts.
    Keywords: AEROSPACE MEDICINE
    Type: NASA., JSC Biomed. Results from Skylab; p 366-371
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
    Electronic Resource
    Electronic Resource
    Warm hydrostatic extrusion of polyethylene (1978)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 18 (1978), S. 908-916 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Hydrostatic extrusion of high density polyethylene at an extrusion ratio of 15:1 was investigated in the temperature range between 100 and 134°C. A thin-walled tube was extruded having a tensile strength of 370 MPa and a tensile modulus of 10 GPa. The extrusion rate was limited by severe extrudate distortion which occurs at a limiting shear stress under stick-slip conditions. Even during steady extrusion wall slip was evident. At a constant extrusion speed, the extrusion pressure was found to be very sensitive to the extrusion temperature. An increase from 120 to 125°C reduced the extrusion pressure by half. Various thermal pretreatments of the starting billets were found to have little effect on the extrusion behavior and physical properties of the extrudate.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760181115
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in nuclear DNA and RNA during epidermal keratinization (1977)
    Springer
    Cell & tissue research 184 (1977), S. 155-167 
    Details
    ISSN: 1432-0878
    Keywords: Epidermal cell differentiation ; DNA and RNA ; GMA embedded tissue ; Enzyme digestion ; Schiff-Thallium reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The distribution of nucleic acids within nuclei of epidermal cells in skin from guinea-pig ear was investigated using an indirect enzyme digestion technique to observe both DNA and RNA, and a direct Schiff-Thallium reaction technique, to observe DNA alone. Similar results were obtained by both methods. The distribution of DNA and RNA change gradually in nuclei as epidermal cells differentiate. DNA in cells of the lower strata is localized in essentially the same areas in which electron-opaque components are seen by conventional electron microscopy. With the cytochemical treatments, however, we found that DNA is not present in all electron-opaque areas of nuclei in superficial granular cells. RNA is present in the nucleoli of cells in all layers, but its density is also lower in the upper granular cells. We postulate that nucleic acids in nuclei of granular cells gradually decrease and that the space is filled with newly synthesized electron-dense protein, as part of the differentiation process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223065
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    Paper (German National Licenses)
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