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  • liver  (5)
  • Springer  (5)
  • 1975-1979  (5)
  • 1955-1959
  • 1976  (5)
Collection
Keywords
Publisher
  • Springer  (5)
Years
  • 1975-1979  (5)
  • 1955-1959
Year
  • 1
    Electronic Resource
    Electronic Resource
    Changes in the structure of chromatin in hepatocyte nuclei of rats adapted to hypoxia (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 445-448 
    Details
    ISSN: 1573-8221
    Keywords: hypoxia ; liver ; structure of hepatocyte chromatin ; Acridine Orange ; microfluorometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The structure of chromatin in the nuclei of isolated surviving hepatocytes and of isolated hepatocyte nuclei was studied by fluorochroming with Acridine Orange and microfluorometry of the luminescence of chromatin-bound dye at 530 and 590 nm in intact rats and rats adapted to hypoxia in a pressure chamber for 60 days. Hepatocyte nuclei of intact rats were shown to be distributed on the basis of their fluorescence at 530 nm into three classes, with a ratio between intensities of 1∶2∶4, whereas hepatocyte nuclei of rats adapted to hypoxia formed only one class, corresponding to the second class in the control. The ratio between the intensities of luminescence at 590 nm and 530 nm (the coefficient α) forms a normal distribution in intact rats, but in adapted rats it formed a bimodal distribution with a shaft of the maxima toward both sides of the control. During hypoxia repression of some genes and depression of others is considered to take place in the chromatin of liver nuclei.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00804945
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of parenteral administration of exogenous cytochrome c on cytochrome content in the liver of rabbits with chronic carbon tetrachloride poisoning (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1516-1517 
    Details
    ISSN: 1573-8221
    Keywords: carbon tetrachloride ; liver ; cytochrome c
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Administration of exogenous cytochrome c to rabbits with chronic poisoning prevented the decrease in the content of cytochrome c in homogenates and of cytochromesa+a 3, b, and c+c1 in the mitochondria of the liver and promoted restoration of the normal histological structure of the organ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799796
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  • 3
    Electronic Resource
    Electronic Resource
    Assimilatory and excretory function of the isolated perfused dog liver (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 489-491 
    Details
    ISSN: 1573-8221
    Keywords: liver ; liver functions ; bromsulfthalein method ; perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In experiments on dogs the assimilatory-excretory function of the liver was studied by means of the bromsulfthalein method in the intact animal and during perfusion of the isolated organ through the portal vein by means of an artificial circulation apparatus. Under perfusion conditions the rate of uptake of the dye was 50–60% of the value of this index in the intact animal. The rate of elimination of bromsulfthalein with the bile and the biliary plasma clearance in the intact animal were five to six times higher. The main cause of the reduction in the assimilatory-excretory function of the isolated liver is evidently hypoxia developing after denervation and removal of the organ from the body, and also during extracorporeal perfusion itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00797546
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of carbon tetrachloride on RNA metabolism in the rat liver (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 677-680 
    Details
    ISSN: 1573-8221
    Keywords: carbon tetrachloride ; liver ; total, nuclear, and cytoplasmic RNA ; RNA turnover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of systematic administration of carbon tetrachloride (CCl4) to rats on the RNA content in the liver and the intensity of incorporation of the labeled precursor (uridine-H3) into it was investigated. Comparison of the results of morphological and biochemical studies revealed two consecutive stages of the toxic process, terminating in the formation of septal fibrosis. The sharpest changes in rapid RNA turnover in the rat liver were observed during the first 3 months of action of the toxic agent. The disturbance of metabolism also was reflected in a lowered RNA level and changes in the nucleo-cytoplasmic ratio in the tissue of the affected liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00797127
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of disturbance of the innervation of the liver and loss of bile on biliary and hepatic enzyme activity (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 847-849 
    Details
    ISSN: 1573-8221
    Keywords: enzymes ; liver ; disturbance of innervation ; loss of bile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Continuous loss of bile from rats with a bile reservoir connected to the common bile duct led to an increase in specific activity of malate, lactate, glutamate, and glucose-6-phosphate dehydrogenases, alkaline and acid phosphatases, urokinase, and histidase in liver homogenates by the seventh day. By the tenth day their specific activity had fallen. After disturbance of the innervation of the rats' livers the ATP concentration fell sharply and the specific activity of the above-mentioned enzymes in the liver was considerably inhibited. During continuous loss of bile, fluctuating changes took place in the specific activity of these enzymes and also of sorbitol dehydrogenase in the bile, starting from the first and continuing until the tenth day of the experiment. Support for the view that these fluctuations were under the control of the nervous system was given by the considerable changes in their character following disturbance of the hepatic innervation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00802999
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