ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Trimethylsilylmethylpotassium and other outstanding metallating agents.For the metallation of allylic and benzylic positions, trimethylsilylmethylpotassium is the most powerful reagent. Butyllithium in the presence of potassium t-butoxide however, can usually replace it. Olefinic and cyclopropane hydrogen atoms are most readily attacked by pentylsodium, especially if the reaction is carried out in presence of potassium t-butoxide. Trimethylsilylmethylpotassium, however, will equally work if an activating group, such as methoxy, is present in the substrate. Generalisations concerning the metallation mechanisms are drawn.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19760590212
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