ISSN:
1573-8221
Keywords:
experimental allergic encephalomyelitis
;
lymphocytes
;
blast transformation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Experimental allergic encephalomyelitis (EAE) was induced in guinea pigs by injection of myelin from homologous brain in Freund's complete adjuvant. In the incubation period of EAE some animals showed a marked increase in the spontaneous proliferative activity of the blood lymphocytes, assessed in cultures using thymidine-H3. With the development of clinical manifestations of the disease, the spontaneous activity of the lymphocytes reached a maximum and was exhibited in the overwhelming majority of animals. When the clinical picture of EAE was well marked, the response of the lymphocytes to stimulation by myelin preparations was observed mainly if the spontaneous mitotic activity of the cells was low or only moderately increased. Specific antigenic stimulation in vivo connected with the immunopathological process could be the cause of the increasing spontaneous activity of the lymphocytes. The state of nonspecific reactivity of the lymphocytes to phytohemagglutinin in EAE was indistinguishable from that in the control animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00808873
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