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The effect of particle size on the absorption of digoxin (1974)

Shaw, T. R. D. ; Carless, J. E.

Springer

European journal of clinical pharmacology 7 (1974), S. 269-273

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ISSN: 1432-1041

Keywords: Digoxin ; particle size ; bioavailability

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary Measurement was made of digoxin particle size in three brands of digoxin powder used for tablet manufacture. The geometric mean particle diameters were 20, 22 and 29 µm. When the 22 µm powder was administered within a cachet absorption of the digoxin occurred slowly and low steady state levels were obtained. Ball milling of the 22 µm powder was used to produce powders of mean diameters 12 and 3.7 µm. These powders produced more rapid and more complete absorption of the digoxin. The results indicate that particle size is a major factor in the biological availability of digoxin formulations.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00560343

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