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  • Coleoptera
  • oxidation
  • pheromone
  • Springer  (2)
  • Annual Reviews
  • 1985-1989
  • 1975-1979
  • 1970-1974  (2)
  • 1974  (2)
Collection
Publisher
  • Springer  (2)
  • Annual Reviews
Years
  • 1985-1989
  • 1975-1979
  • 1970-1974  (2)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 7 (1974), S. 461-466 
    ISSN: 1432-1041
    Keywords: Acetanilide ; oxidation ; diphenylhydantoin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Acetanilide and diphenylhydantoin have a similar first stage biotransformation in that both are oxidized in the para position of the benzene ring incorporated in each of the two molecules. The elimination of acetanilide from the plasma was studied in thirty healthy volunteer subjects following a single oral dose of 50 mg per kg metabolically active mass (MAM = weight to the power of 0.7). Plasma clearance values varied from 12.4 to 25.11 per hour. A dose of 5 mg diphenylhydantoin sodium (DPH) per kg MAM was then given thrice daily for 13 days to the same volunteers. The steady state plasma concentrations of DPH varied from 3.4 to 19.6 µg per ml. Statistically significant correlation was demonstrated between plasma acetanilide clearance and DPH clearance (r=+0.4984). This finding suggests either a common enzyme acceptor or a common rate-limiting step in the metabolism of the two drugs. It is possible that the pharmacokinetics of other widely used drugs known to be oxidized, especially phenylbutazone, may also be correlated with the kinetics of acetanilide and of DPH. If this were so, then certain individuals might be at a relatively high risk (due to drug accumulation) of developing adverse effects from drugs metabolized mainly by oxidation, and certain other individuals who metabolize these compounds at a fast rate are likely not to derive therapeutic benefit. A single dose study with simple measurement of acetanilide pharmacokinetics could be used to identify these groups.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Oxidation of metals 8 (1974), S. 393-407 
    ISSN: 1573-4889
    Keywords: cobalt alloys ; oxidation ; manganese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Earlier studies have suggested that manganese might be attractive as an alternative fcc stabilizer to nickel in cobalt base alloys because of its beneficial effect on the sulfidation resistance. Because it has relatively high oxygen affinity, it seemed possible that it might modify the ability of the alloys to form a protective Cr 2O3 scale. Thus, a range of alloys having compositions close to the critical Co-20 Cr value have been investigated in the temperature range 900–1150° C for times up to 240 hr in air and oxygen. Similar, but less extensive studies, have been conducted on alloys containing iron or nickel. None of these elements has a significant effect on the oxidation behavior, or on the ability of the alloys to develop a protective Cr 2O3 layer. However, manganese has a significant adverse effect on the scale spallation, apparently because of its increasing the brittleness of the oxide, particularly the CoO.
    Type of Medium: Electronic Resource
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