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  • Cell & Developmental Biology  (1)
  • Malaria  (1)
  • 1990-1994
  • 1975-1979
  • 1970-1974  (2)
  • 1890-1899
  • 1974  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of tolbutamide on the metabolism of Tetrahymena (1974)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 83 (1974), S. 275-286 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Tolbutamide partially inhibited the growth but increased the glycogen content of Tetrahymena pyriformis in logarithmically growing cultures. Tolbutamide slightly increased 14CO2 production from [1-14C] and [6-14HC] glucose and [2-14C] pyruvate, but had little effect on the oxidation of [1-14C] acetate when any of these substrates were added to the proteose-peptone medium in which the cells had been grown. Measurement of 14CO2 production from [1-14C] and [2-I4C]-glyoxylate showed that this substrate was primarily oxidized via the glyoxylate cycle, with little if any oxidation occurring via the peroxisomal glyoxylate oxidase. Addition of tolbutamide inhibited the glyoxylate cycle as indicated by a marked reduction in label appearing in CO2 and in glycogen from labeled acetate. In control cells, addition of acetate strongly inhibited the oxidation of [2-14C]-pyruvate whereas addition of pyruvate had little effect on the oxidation of [1-14C]-acetate. Acetate was more effective than pyruvate in preventing the growth inhibitory and glycogen-increasing effects of tolbutamide. The data suggest that one effect of tolbutamide may be to interfere with the transfer of isocitrate and acetyl CoA across mitochondrial membranes.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040830215
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  • 2
    Electronic Resource
    Electronic Resource
    Antimetabolites of Coenzyme Q. Their Potential Application as Antimalarials (1974)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 13 (1974), S. 559-569 
    Details
    ISSN: 0570-0833
    Keywords: Antimetabolites ; Coenzyme Q ; Antimalarial agents ; Malaria ; Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Malaria is transmitted to man by the bite of the female Anopheles mosquito, man acting as the intermediate host, and the mosquito as the definitive host for the plasmodia. Plasmodia are found to have become resistant to certain chemotherapeutic agents. A new fundamental approach to malaria chemotherapy is based on the biochemical rationale of inhibition of the electron transfer mechanism in the metabolism of plasmodia by antimetabolites of coenzyme Q, which is essential for electron transfer. Coenzyme Q refers to 2,3-dimethoxy-5-methyl-1,4-benzoquinones with isoprenoid chains of varying length on C-6. In this progress report a series of synthetic antimetabolites are presented together with a discussion of their action in current pharmacological tests.
    Additional Material: 8 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.197405591
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