ISSN:
1573-8744
Keywords:
tetracycline
;
bioavailability
;
urinary excretion
;
human studies
;
generic equivalence
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Tests were conducted on the relative bioavailability of single lots of 16 different 250-mg tetracycline hydrochloride or tetracycline phosphate complex capsule products commercially available in the United States. All products met the specifications of the Food and Drug Administration for antibiotic certification. Complete crossover studies were carried out with each of the 16 products administered to 16 human volunteers over a period of 16 weeks. The urinary excretion of the tetracycline was followed for 72 hr after the single dose administration. No statistically significant differences were observed, in the cumulative percent of tetracycline excreted, between any of the products or any of the subjects employed in the study.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01061403
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