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  • Springer  (14)
  • 1975-1979  (5)
  • 1970-1974  (9)
  • 1920-1924
  • 1905-1909
  • 1979  (5)
  • 1973  (9)
  • 1
    Electronic Resource
    Electronic Resource
    The chronic toxicity of hexamethylphosphoramide in rats (1973)
    Springer
    Bulletin of environmental contamination and toxicology 10 (1973), S. 225-226 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01684548
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Progress in remote optical analysis of lunar surface composition (1973)
    Springer
    Earth, moon and planets 7 (1973), S. 453-474 
    Details
    ISSN: 1573-0794
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00564646
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Observations on the regulation of uricase activity during development of Drosophila melanogaster (1973)
    Springer
    Biochemical genetics 8 (1973), S. 37-45 
    Details
    ISSN: 1573-4927
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract To elucidate the mechanisms involved in the regulation of uricase activity in Drosophila melanogaster, a comparative analysis of the patterns of uricase activity during development was undertaken for the wild type, Ore-R, and the mutants ry 2 and ma-1. Uricase activity in ry 2 and ma-l, unlike that in Ore-R, increased rapidly following emergence of the adult. This study indicates that uricase in Drosophila, in contrast to that in several microorganisms, is not induced by uric acid, since ry 2 and ma-l with no detectable uric acid have higher activity than the wild type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00485555
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The policy implementation process (1973)
    Springer
    Policy sciences 4 (1973), S. 197-209 
    Details
    ISSN: 1573-0891
    Source: Springer Online Journal Archives 1860-2000
    Topics: Political Science , Economics
    Notes: Abstract There is an implicit assumption in most policy studies that once a policy has been formulated the policy will be implemented. This assumption is invalid for policies formulated in many Third World nations and for types of policies in Western societies. Third World governments tend to formulate broad, sweeping policies, and governmental bureaucracies often lack the capacity for implementation. Interest groups, opposition parties, and affected individuals and groups often attempt to influence the implementation of policy rather than the formulation of policy. A model of the policy implementation process is presented. Policy implementation is seen as a tension generating force in society. Tensions are generated between and within four components of the implementing process: idealized policy, implementing organization, target group, and environmental factors. The tensions result in transaction patterns which may or may not match the expectations of outcome of the policy formulators. The transaction patterns may become crystallized into institutions. Both the transaction patterns and the institutions may generate tensions which, by feedback to the policymakers and implementors, may support or reject further implementation of the policy. By application of the model, policymakers can attempt to minimize disruptive tensions which can result in the failure of policy outcomes to match policy expectations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405732
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  • 5
    Electronic Resource
    Electronic Resource
    Policy roles: an analysis of policy formulators and policy implementors (1973)
    Springer
    Policy sciences 4 (1973), S. 297-307 
    Details
    ISSN: 1573-0891
    Source: Springer Online Journal Archives 1860-2000
    Topics: Political Science , Economics
    Notes: Abstract This paper presents an empirical analysis of individuals in policy formulating and policy implementing roles. Data for the comparison are from interviews with a random sample of 119 New Zealand middle-level public administrators from 27 government departments. The individuals in the policy formulating roles were slightly younger; however, those in the formulating and implementing roles varied little from each other in terms of social background, educational attainment and career patterns. Few differences were evident in regard to job satisfaction, decisional authority, and hierarchical relations. Significant differences between policy formulators and policy implementors were discovered in terms of work load, career aspirations, and awareness of political influences in governmental policymaking. From the evidence of this study, the New Zealand administrative system does not allocate policy formulating roles to individuals different from those who implement policies. Differences between formulators and implementors in the New Zealand system appear to stem from the nature of the work of the two policy roles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01435126
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  • 6
    Electronic Resource
    Electronic Resource
    Genetics of the cell surface: Assignment of genes coding for external membrane proteins to human chromosomes 10 and 14 (1979)
    Springer
    Somatic cell and molecular genetics 5 (1979), S. 281-301 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Using somatic cell hybridization gene mapping methodology, genes coding for human cell-surface proteins have been assigned to specific chromosomes. Lactoperoxidase-catalyzed iodination was employed to label external membrane proteins in cell hybrids between mouse and human cultured cells. Mouse and human external membrane proteins were separated by sodium dodecylsulfate-polyacrylamide gel electrophoresis. After electrophoresis, external membrane proteins were identified by autoradiography. An external membrane protein of 130,000 molecular weight (EMP-130) segregated concordantly with glutamic oxaloacetic transaminases (GOTs, EC 2.6.1.1), an enzyme marker encoded on chromosome 10. External membrane proteins of 195,000 and 175,000 molecular weight (EMP-195 and EMP-175) segregated concordantly with nucleoside phosphorylase (NP, EC 2.4.2.1), an enzyme marker encoded on chromosome 14. Limited proteolysis of the 195,000 and 175,000 molecular weight proteins suggests that these two proteins are modified forms of each other and are encoded by the same locus. These findings demonstrate the mapping of human genes coding for external proteins EMP-130 and EMP-195 to chromosomes 10 and 14, respectively. Chromosome analyses of cell hybrids supported these assignments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01538843
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Bioautographic visualization of aminoacylase-1: Assignment of the structural geneACY-1 to chromosome 3 in man (1979)
    Springer
    Somatic cell and molecular genetics 5 (1979), S. 11-21 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A bioautographic assay was developed for the visualization of aminoacylase-1 (N -acylamino acid aminohydrolase, ACY-1; EC 3.5.1.14) after zone electrophoresis. Bioautography and species differences in electrophoretic mobility of ACY-1 made it possible to investigate the chromosome assignment of the gene for human ACY-1 using human—mouse somatic cell hybrids. Human ACY-1 segregated concordantly with β-galactosidase-A (βGAL A;EC 3.2.1.23) but showed discordant segregation with 32 other markers representing 23 linkage groups. The β GALA gene has been previously assigned to chromosome 3. From this evidence and confirming chromosome analyses, ACY-1has been assigned to chromosome 3. A genetic polymorphism in the electrophoretic mobility of ACY was observed in mouse strains, demonstrating that this enzyme can be mapped in genetic crosses of Mus musculus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01538782
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  • 8
    Electronic Resource
    Electronic Resource
    GM1-gangliosidosis: Chromosome 3 assignment of theβ-galactosidase-A gene (β GAL A ) (1979)
    Springer
    Somatic cell and molecular genetics 5 (1979), S. 147-158 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The structural gene (βGALA) coding for lysosomal β-galactosidase- A (EC 3.2.1.23) has been assigned to human chromosome 3 using man-mouse somatic cell hybrids. Human β-galactosidase-A was identified in cell hybrids with a species-specific antiserum to human liver β-galactosidase-A. The antiserum precipitates β-galactosidase-A from human tissues, cultured cells, and cell hybrids, and recognizes cross-reacting material from a patient with GM1 gangliosidosis. We have analyzed 90 primary man-mouse hybrids derived from 12 separate fusion experiments utilizing cells from 9 individuals. Enzyme segregation analysis excluded all chromosomes for βGALA assignment except chromosome 3. Concordant segregation of chromosomes and enzymes in 16 cell hybrids demonstrated assignment of βGALA to chromosome 3; all other chromosomes were excluded. The evidence suggests that GM1 gangliosidosis is a consequence of mutation at this βGALA locus on chromosome 3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01539157
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  • 9
    Electronic Resource
    Electronic Resource
    Complementation of genetic disease: A velocity sedimentation procedure for the enrichment of heterokaryons (1979)
    Springer
    Somatic cell and molecular genetics 5 (1979), S. 1013-1029 
    Details
    ISSN: 1572-9931
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Methodology is described to enrich for heterokaryons after mammalian cell fusion. A heterogeneous cell mixture can be separated on a Sta-Put apparatus into fractions of uniform size cells by sedimentation through a 1% bovine serum albumin-5% Ficoll gradient. Unfused RAG and LM/TK− cells, differing by 10% in diameter, have been sorted by size; following fusion, larger and faster sedimenting cells were shown to be hybrids. This methodology can be utilized in genetic complementation studies of human genetic diseases where selection procedures for proliferating hybrids do not exist. When fibroblasts from individuals with Tay-Sachs disease [deficient in hexosaminidase A (HEX A−)] and Sandhoff-Jatzkewitz disease (HEX A− and HEX B−) are fused, HEX A is generated, demonstrating complementation of two different mutations. After Sta-Put fractionation, the HEX A complementation product was associated with the faster sedimenting multinuclear cells and not with the mononuclear parental cells. This methodology will facilitate detection of genetic differences in fibroblasts from related inherited disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01542657
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  • 10
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    Progress in remote optical analysis of lunar surface composition (1973)
    Springer
    Details
    Publication Date: 1973-01-01
    Print ISSN: 0027-0903
    Topics: Geosciences , Physics
    Published by Springer
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