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  • Cell & Developmental Biology
  • STRUCTURAL MECHANICS
  • 1980-1984
  • 1975-1979  (59)
  • 1970-1974  (60)
  • 1960-1964
  • 1950-1954
  • 1979  (59)
  • 1972  (60)
Collection
Keywords
Publisher
Years
  • 1980-1984
  • 1975-1979  (59)
  • 1970-1974  (60)
  • 1960-1964
  • 1950-1954
Year
  • 1
    Electronic Resource
    Electronic Resource
    Partial regeneration of the above-elbow amputated rat forelimb. II. Electrical and mechanical facilitationSupported by the Veterans Administration Medical Research Program Project Number 7004-04 and a Medical Investigatorship Award to P.P. (1979)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 159 (1979), S. 439-451 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: This investigation was undertaken to examine the observations of Becker ('72) pertaining to the electrical facilitation of partial limb regenerative responses by means of Ag-Pt wire couples applied to the limb stumps of young, forelimb-amputated white rats. Additionally, in order to examine the possible role of mechanical effects of such device implantations, we have employed uncoupled devices delivering no current or potential difference. In the present experiments, in response to coupled device implantation, cartilage and bone were actively formed in the vicinity of the Pt electrode tip. These tissues contributed to the lengthwise extension of the limb and to the partial restoration of the distal humeral extremity. In limbs bearing the uncoupled electrical devices, qualitatively similar responses were noted, but osteogenesis was diminished in extent compared to that seen in limbs bearing the active or coupled devices. It is therefore necessary to consider the role of mechanical factors in the elicitation of the observed regenerative responses. Myogenesis was enhanced in electrically stimulated limbs, but not in those rats bearing uncoupled devices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051590309
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Competitive in vivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 79 (1972), S. 293-298 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The relative proliferative capacity of haematopoietic cell populations derived from 22-week-old adult bone marrow and 14-18 day foetal liver has been studied in lethally irradiated syngeneic recipients by means of chromosome markers. Although starting at a disadvantage in terms of the number of colony-forming units (stem cells) injected, the foetal liver-derived populations steadily increased their relative numbers in the myeloid and lymphoid tissues over a period of several weeks until a plateau was reached. It is suggested that stem cells in foetal liver have, on average, a higher intrinsic capacity for self-renewal than do those in bone marrow, and that this capacity falls to the adult level within about ten weeks of transfer.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040790214
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lymphopoiesis in the rat. II. The effect of thymectomySupported by grant IC-18A from the American Cancer Society, grant AI-08642 from the National Institute of Allergy and Infectious Disease and grant 211-12-E(13) from the National Tuberculosis and Respiratory Disease Association, Inc. (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 80 (1972), S. 13-21 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Lymphopoiesis with respect to recirculating and non-recirculating small lymphocytes was measured simultaneously in rats thymectomized as adults. Removal of the thymus at four to five weeks of age had a profound inhibitory effect upon the production of recirculating cells, whereas the formation of non-recirculating lymphocytes was only slightly depressed. Thymectomy had approximately the same impact of lymphopoiesis as thymectomy and exposure of the animal to a large dose of whole body X- and γ-irradiation. The latter finding, and the failure of a thoracic duct cell transfusion to augment lymphocyte production, accord with the view that the thymus is the principle intermediate source of recirculating small lymphocytes in the normal, unstimulated animal.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040800103
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  • 4
    Electronic Resource
    Electronic Resource
    Lymphopoiesis in the rat. I. The effect of pool size on lymphocyte productionSupported by grant IC-18A from the American Cancer Society, grant AI-08642 from the National Institute of Allergy and Infectious Disease and grant 211-12-E(13) from the National Tuberculosis and Respiratory Disease Association, Inc. (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 80 (1972), S. 1-12 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A method is described for measuring lymphopoiesis that enables the production of recirculating and non-recirculating small lymphocytes to be estimated simultaneously. Using this technique, experiments were undertaken to determine whether the production of recirculating cells is influenced by the number present in the recirculating lymphocyte pool. The results suggest that neither a massive lymphocyte transfusion nor depletion of the pool by whole body irradiation or chronic lymph drainage affect the rate at which recirculating small lymphocytes are generated.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040800102
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  • 5
    Electronic Resource
    Electronic Resource
    Calcium-mediated effects of calcitonin on cyclic AMP formation and lymphoblast proliferation in thymocyte populations exposed to prostaglandin E1Issued as NRCC 12843. (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 80 (1972), S. 315-328 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The calcitonin (SCT) from salmon ultimobranchial bodies which (like mammalian calcitonins) lowers the plasma calcium concentration in mammals can also affect cyclic AMP (cyclic adenosine 3′,5′-monophosphate) metabolism and proliferation of lymphoblasts in normal and prostaglandin E1 (PGE1)-treated rat thymocyte populations in three different ways. In the first case, low concentrations (0.5-5.0 ng per milliliter) of SCT lower (by a calcium-mediated process) the ability of PGE1 to transiently increase cyclic AMP synthesis, but the reduced surge of cyclic AMP production is still ample to stimulate lymphoblasts in the cell population to initiate deoxyribonucleic acid (DNA) synthesis. Secondly, these low SCT concentrations affect the eventual progression of the PGE1-stimulated, DNA-synthesizing lymphoblasts into mitosis by a calcium-mediated process. Depending on the extracellular calcium concentration and the magnitude of the initial increment in the intracellular cyclic AMP content, SCT can either promote or inhibit the progression of the stimulated cells into mitosis. SCT's third action is a rapid (within 5 minutes), calcium-independent elevation of the cellular cyclic AMP content in otherwise untreated thymic lymphocyte populations exposed to a very high concentration (100 ng per milliliter) of the hormone. This early, transient rise in the cyclic AMP level is followed by a calcium-dependent increase in lymphoblast proliferation. An attempt is made to interrelate and explain the different actions of SCT on cyclic AMP metabolism and mitogenesis.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040800302
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  • 6
    Electronic Resource
    Electronic Resource
    Control of the Balb/c-3T3 cell cycle by nutrients and serum factors: Analysis using platelet-derived growth factor and platelet-poor plasma (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 99 (1979), S. 395-405 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Much controversy regarding the relationship between nutrients and serum in regulation of cell growth can be reconciled by recognizing that serum contains multiple factors which regulate different events in the cell cycle. Serum was fractioned into a platelet-derived growth factor (PDGF), which induces cells to become competent to synthesize DNA, and plasma which allows competent cells to traverse G0/G1 and enter the S phase. Nutrients are not required for the cellular response to PDGF; however amino acids are required for plasma to promote the entry of PDGF-treated, competent cells into S phase. The nutrient independent, PDGF-modulated, growth regulatory event (competence) is located 12 hours prior to the G1/S phase boundary in quiescent, density-arrested Balb/c-3T3 cells. The nutrient dependent, plasma-modulated event is located six hours prior to the G1/S phase boundary and corresponds in time to a plasma dependent growth arrest point. Moreover, plasma controls the concentration of amino acids required for DNA synthesis. Infection of density-arrested Balb/c-3T3 cells with SV40 overrides both the nutrient independent and the nutrient dependent growth regulatory events.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040990314
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  • 7
    Electronic Resource
    Electronic Resource
    The tumor promoter 12-0-tetradecanoyl-phorbol-13-acetate enhances the proliferative response of Balb/c-3T3 cells to hormonal growth factors (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 100 (1979), S. 413-424 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Stimulation of Balb/c-3T3 cell growth by TPA requires factors found in serum. We examined the interaction between TPA and serum growth factors in the stimulation of cell growth. The number of cells synthesizing DNA (incorporating 3H-thymidine) within 24 to 30 hours after the addition of TPA and the growth factors to density-inhibited Balb/c-3T3 cultures in serum-free medium was determined by autoradiography. With no additions or with TPA (30-300 ng/ml) alone, only 3-7% of cells synthesized DNA. However, TPA synergistically promoted DNA synthesis in combination with each of the defined serum growth fractions, platelet derived growth factor and platelet poor plasma. TPA also synergistically promoted DNA synthesis in combination with purified growth factors including fibroblast growth factor, insulin (10-6-10-5 M), and epidermal growth factor. In all conditions, TPA enhancement of DNA synthesis also resulted in an increase in cell number. Because TPA synergistically enhanced the activity of each growth factor tested, it did not act identically to any of the growth factors.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041000305
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  • 8
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    A non-linear dynamic lumped-parameter model of a rectangular plate. (1972)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: A lumped-parameter model of a rectangular plate is developed by assuming fundamental mode solutions and using Hamilton's Principle and the Euler equations to set up the differential equation of motion for the system. The plate theory used may be described as the dynamic analogue of the von Karman large-deflection theory. Four sets of symmetrical boundary conditions are considered with the restriction of uniform pressure dynamic loads. The model takes the form of a mass on a cubic-hardening spring with each term defined by algebraic expressions of the plate parameters. The results for some specific problems are compared with two previous solutions. This method is less accurate but simpler to develop and apply.
    Keywords: STRUCTURAL MECHANICS
    Type: Journal of Sound and Vibration; 21; Apr. 8
    Format: text
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    NASA TECHNICAL REPORTS
  • 9
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    A comparison of the capabilities of three finite element programs (1972)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: Three finite element programs are compared to assess their capabilities as an analysis tool in a structural design process. Because of the need for repetitive analyses as an integral part of a design loop, a candidate program must be capable of handling large problems, operate efficiently, and be readily adaptable for use in computer-aided design. The three programs considered in the study, ELAS,SNAP, and NASTRAN, range from a relatively small finite element program limited to static structural analysis (ELAS) to a large complex general analysis system (NASTRAN). Results are given for comparative speeds and computer resources required for each program in the analysis of sample fuselage problems representative of practical aircraft design.
    Keywords: STRUCTURAL MECHANICS
    Type: NASA. Langley Res. Center NASTRAN: Users' Experiences; p 277-287
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 10
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    Experiences in interfacing NASTRAN with another finite element program (1972)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: The coupling of NASTRAN to another finite element program developed for the static analysis of automotive structures is discussed. The two programs were coupled together to use the substructuring capability of the in-house program and the normal mode analysis capability of NASTRAN. Modifications were made to the NASTRAN program in order to make the coupling feasible.
    Keywords: STRUCTURAL MECHANICS
    Type: NASA. Langley Res. Center NASTRAN: Users' Experiences; p 111-119
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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