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  • AIRCRAFT  (70)
  • Cell & Developmental Biology
  • STRUCTURAL MECHANICS
  • 1980-1984
  • 1975-1979  (44)
  • 1970-1974  (130)
  • 1960-1964
  • 1950-1954
  • 1977  (44)
  • 1972  (130)
Collection
Keywords
Publisher
Years
  • 1980-1984
  • 1975-1979  (44)
  • 1970-1974  (130)
  • 1960-1964
  • 1950-1954
Year
  • 1
    Electronic Resource
    Electronic Resource
    Competitive in vivo proliferation of foetal and adult haematopoietic cells in lethally irradiated mice (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 79 (1972), S. 293-298 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The relative proliferative capacity of haematopoietic cell populations derived from 22-week-old adult bone marrow and 14-18 day foetal liver has been studied in lethally irradiated syngeneic recipients by means of chromosome markers. Although starting at a disadvantage in terms of the number of colony-forming units (stem cells) injected, the foetal liver-derived populations steadily increased their relative numbers in the myeloid and lymphoid tissues over a period of several weeks until a plateau was reached. It is suggested that stem cells in foetal liver have, on average, a higher intrinsic capacity for self-renewal than do those in bone marrow, and that this capacity falls to the adult level within about ten weeks of transfer.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040790214
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lymphopoiesis in the rat. II. The effect of thymectomySupported by grant IC-18A from the American Cancer Society, grant AI-08642 from the National Institute of Allergy and Infectious Disease and grant 211-12-E(13) from the National Tuberculosis and Respiratory Disease Association, Inc. (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 80 (1972), S. 13-21 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Lymphopoiesis with respect to recirculating and non-recirculating small lymphocytes was measured simultaneously in rats thymectomized as adults. Removal of the thymus at four to five weeks of age had a profound inhibitory effect upon the production of recirculating cells, whereas the formation of non-recirculating lymphocytes was only slightly depressed. Thymectomy had approximately the same impact of lymphopoiesis as thymectomy and exposure of the animal to a large dose of whole body X- and γ-irradiation. The latter finding, and the failure of a thoracic duct cell transfusion to augment lymphocyte production, accord with the view that the thymus is the principle intermediate source of recirculating small lymphocytes in the normal, unstimulated animal.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040800103
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Lymphopoiesis in the rat. I. The effect of pool size on lymphocyte productionSupported by grant IC-18A from the American Cancer Society, grant AI-08642 from the National Institute of Allergy and Infectious Disease and grant 211-12-E(13) from the National Tuberculosis and Respiratory Disease Association, Inc. (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 80 (1972), S. 1-12 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: A method is described for measuring lymphopoiesis that enables the production of recirculating and non-recirculating small lymphocytes to be estimated simultaneously. Using this technique, experiments were undertaken to determine whether the production of recirculating cells is influenced by the number present in the recirculating lymphocyte pool. The results suggest that neither a massive lymphocyte transfusion nor depletion of the pool by whole body irradiation or chronic lymph drainage affect the rate at which recirculating small lymphocytes are generated.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040800102
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  • 4
    Electronic Resource
    Electronic Resource
    Calcium-mediated effects of calcitonin on cyclic AMP formation and lymphoblast proliferation in thymocyte populations exposed to prostaglandin E1Issued as NRCC 12843. (1972)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 80 (1972), S. 315-328 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The calcitonin (SCT) from salmon ultimobranchial bodies which (like mammalian calcitonins) lowers the plasma calcium concentration in mammals can also affect cyclic AMP (cyclic adenosine 3′,5′-monophosphate) metabolism and proliferation of lymphoblasts in normal and prostaglandin E1 (PGE1)-treated rat thymocyte populations in three different ways. In the first case, low concentrations (0.5-5.0 ng per milliliter) of SCT lower (by a calcium-mediated process) the ability of PGE1 to transiently increase cyclic AMP synthesis, but the reduced surge of cyclic AMP production is still ample to stimulate lymphoblasts in the cell population to initiate deoxyribonucleic acid (DNA) synthesis. Secondly, these low SCT concentrations affect the eventual progression of the PGE1-stimulated, DNA-synthesizing lymphoblasts into mitosis by a calcium-mediated process. Depending on the extracellular calcium concentration and the magnitude of the initial increment in the intracellular cyclic AMP content, SCT can either promote or inhibit the progression of the stimulated cells into mitosis. SCT's third action is a rapid (within 5 minutes), calcium-independent elevation of the cellular cyclic AMP content in otherwise untreated thymic lymphocyte populations exposed to a very high concentration (100 ng per milliliter) of the hormone. This early, transient rise in the cyclic AMP level is followed by a calcium-dependent increase in lymphoblast proliferation. An attempt is made to interrelate and explain the different actions of SCT on cyclic AMP metabolism and mitogenesis.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040800302
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  • 5
    Electronic Resource
    Electronic Resource
    The characterization of SV40-transformed cell lines derived from mouse teratocarcinoma: Growth properties and differentiated characteristicsA portion of this work was presented at the Conference on “Regulation of Gene Expression in Development and Neoplasia” which was published in Cancer Research, 36, 4217-4223, 1976. (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 93 (1977), S. 269-276 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Mouse teratocarcinoma cells derived from embryoid bodies of 129SVsl mice were cultured in vitro to permit their differentiation. These cells were then infected with simiam virus 40 (SV40) and 31 cloned cell lines (SVTER) were derived from these cultures. All 31 SVTER cell lines contained the SV40 tumor (T) antigen and grew as permanent lines in culture. Mock-infected embryoid body cultures did not give rise to permanent cell lines. The morphology of each SVTER cell line was distinct and did not change during successive subclonings.The growth properties and tumorigenic potential of all 31 SVTER cell lines were investigated. None of these lines produced tumors in 129SVsl mice. Each cell line was tested for its ability to (1) grow in medium containing 1% serum, (2) plate on a cell monolayer, and (3) form clones in methocel suspension. Only three of the SVTER cell lines were transformed with respect to all three of these criteria. Most of these cell lines were minimal transformation.The SVTER cell lines were tested for creatine phosphokinase (CPK), an enzyme activity characteristic of mouse brain and muscle tissue, and the protease, plasminogen activator (PA) which is found in embryoid bodies and several differentiated cell types. Some of the SVTER cell lines contained high levels of CPK, while others had high levels of PA and a third group of cells contained neither enzyme activity. No SVTER cell line was found with high levels of both these enzyme activities. This result suggests that mutually exclusive sets of genes are expressed in these cells as might be expected from the distinct tissue distribution of the two enzyme activities studied. These SVTER cell lines may be useful in reconstructing developmental pathways of differentiating teratomas in vitro.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040930212
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  • 6
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    Effects of atmospheric irregularities on sonic-boom propagation. (1972)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: A review is given of information obtained in recent years concerning the effects on sonic-boom signatures of departures of the atmosphere from a perfectly stratified time invariant model. These effects include the observed random variations in boom overpressures from those expected for a stratified atmosphere, the anomalously large and variable rise times, and the occurrence of spiked or rounded waveforms rather than the characteristic N waves. The extent of the variability in data recorded during actual flight tests is summarized in the form of histograms, representing experimentally obtained probability density functions. The physical mechanisms believed to be responsible for the variations and the anomalous features in the signatures are described. These include refraction and subsequent wavefront rippling by turbulence, the possible focusing or defocusing of rays, the formation of caustics, and the phenomenon of wavefront folding, diffraction, and scattering. Recent statistical theories of shock propagation through a turbulent atmosphere proposed by Crow, George and Plotkin, Pierce, Horning, and others are reviewed.
    Keywords: AIRCRAFT
    Format: text
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    NASA TECHNICAL REPORTS
  • 7
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    A non-linear dynamic lumped-parameter model of a rectangular plate. (1972)
    In:  Other Sources
    Details
    Publication Date: 2011-08-16
    Description: A lumped-parameter model of a rectangular plate is developed by assuming fundamental mode solutions and using Hamilton's Principle and the Euler equations to set up the differential equation of motion for the system. The plate theory used may be described as the dynamic analogue of the von Karman large-deflection theory. Four sets of symmetrical boundary conditions are considered with the restriction of uniform pressure dynamic loads. The model takes the form of a mass on a cubic-hardening spring with each term defined by algebraic expressions of the plate parameters. The results for some specific problems are compared with two previous solutions. This method is less accurate but simpler to develop and apply.
    Keywords: STRUCTURAL MECHANICS
    Type: Journal of Sound and Vibration; 21; Apr. 8
    Format: text
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    NASA TECHNICAL REPORTS
  • 8
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    Apollo 15 main-parachute failure (1972)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: In the investigation of the failure of one of the three main parachutes of the Apollo 15 spacecraft, which collapsed at approximately 1825 meters after operating properly from deployment at 3050 meters, three conditions considered to be possible causes of the failure were produced. The suspect conditions were the proximity of the forward heat shield that passed the spacecraft at approximately 1825 meters, the dumping of the reaction control system hypergolic propellants at approximately 1825 meters, and the failing of a riser link found on a recovered parachute. (The failed parachute was not recovered). The remaining two parachutes functioned as planned and averted a catastrophic failure. The conclusions concerning the cause of the failure are discussed.
    Keywords: AIRCRAFT
    Type: The 7th Aerospace Mech. Symp.; p 137-148
    Format: application/pdf
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  • 9
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    A comparison of the capabilities of three finite element programs (1972)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: Three finite element programs are compared to assess their capabilities as an analysis tool in a structural design process. Because of the need for repetitive analyses as an integral part of a design loop, a candidate program must be capable of handling large problems, operate efficiently, and be readily adaptable for use in computer-aided design. The three programs considered in the study, ELAS,SNAP, and NASTRAN, range from a relatively small finite element program limited to static structural analysis (ELAS) to a large complex general analysis system (NASTRAN). Results are given for comparative speeds and computer resources required for each program in the analysis of sample fuselage problems representative of practical aircraft design.
    Keywords: STRUCTURAL MECHANICS
    Type: NASA. Langley Res. Center NASTRAN: Users' Experiences; p 277-287
    Format: application/pdf
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  • 10
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    Experiences in interfacing NASTRAN with another finite element program (1972)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: The coupling of NASTRAN to another finite element program developed for the static analysis of automotive structures is discussed. The two programs were coupled together to use the substructuring capability of the in-house program and the normal mode analysis capability of NASTRAN. Modifications were made to the NASTRAN program in order to make the coupling feasible.
    Keywords: STRUCTURAL MECHANICS
    Type: NASA. Langley Res. Center NASTRAN: Users' Experiences; p 111-119
    Format: application/pdf
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