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  • Articles  (10)
  • Life and Medical Sciences  (10)
  • 2020-2023
  • 2010-2014
  • 1965-1969  (10)
  • 1935-1939
  • 1968  (10)
  • 1
    Electronic Resource
    Electronic Resource
    Differentiation of antibody forming cells in lymph nodes during the anamnestic responseThis investigation was supported by Research grants AI-1865 (ABS) and AM-07161 (MDS and RDM), United States Public Health Service. (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 71 (1968), S. 133-150 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The cellular and subcellular events in the anamnestic response were considered. Rabbits previously immunized with key hole limpet hemocyanin (KLH) were given an anamnestic challenge in the hind footpads. The popliteal lymph nodes were removed at intervals after immunization and the following correlated on a temporal basis: the changes in the number and types of cells in the lymph nodes; the formation and regression of ribosomes, polyribosomes, endoplasmic reticulum and Golgi apparatus in plasma cells; the changes in intracellular immunofluorescence for anti-hemocyanin; and, the incorporation of 14C labeled amino acids by lymph node cells into anti-KLH during a brief in vitro culture period.Maximum intracellular fluorescence for anti-KLH and the largest incorporation of 14C labeled amino acids into antibody occurred between the third and fourth day after immunization. During this interval highly differentiated plasma cells were most numerous with respect to the total cellular population. These events took place in a 12 to 24 hour period.This was followed by an abrupt decline in the synthesis of antibody. Coincident with this was a reduction in the number of recognizable plasma cells in the nodes, diminished intracellular fluorescence for anti-KLH and a simplification of the cytoplasm of the plasma cells toward a lymphocytic form.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040710204
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  • 2
    Electronic Resource
    Electronic Resource
    Panel discussion: Present status and perspectives in the study of cytodifferentiation at the molecular level. II. Discussion (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 72 (1968), S. 219-230 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040720415
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  • 3
    Electronic Resource
    Electronic Resource
    A histological study of non-follicular cysts in the ovulation fossa region of the equine ovary (1968)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 124 (1968), S. 313-320 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Forty-two unselected ovaries from adult mares were examined histologically, and with histochemical methods for mucins. A considerable part of the surface of the ovulation fossa was directly covered by columnar epithelium, with many ciliated cells. This epithelium, which was distributed mainly on the anterior side of the ovulation fossa, closely resembled the contiguous epithelium of the infundibulum of the oviduct, was frequently folded, and gave rise to short clefts projecting into the ovarian substance. The remainder of the ovulation fossa was covered by non-ciliated, low cuboidal or squamous epithelium, lacking folds or clefts.“Fossa cysts,” up to 6.5 mm in diameter, were observed in the ovarian tissue around the ovulation fossa in 27 (64%) of these ovaries. Both simple and branched, tubular and vesicular forms were present, and all were blind-ending. Their epithelial lining cells, which varied from simple squamous to columnar in type, were frequently ciliated. Many fossa cysts contained secretions histochemically similar to those of the columnar epithelium of the ovulation fossa and infundibulum. Both sialic acidcontaining and neutral mucins were present. It is suggested that these cysts were probably derived by ingrowth from the columnar epithelium of the ovulation fossa. This epithelium may be of müllerian duct origin.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051240305
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  • 4
    Electronic Resource
    Electronic Resource
    Photoreactivation of amphibian cells in cultureResearch sponsored by the National Cancer Institute, by the U.S. Atomic Energy Commission under contract with the Union Carbide Corporation, and by grant GB-6597 from the National Science Foundation. (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 71 (1968), S. 173-176 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Photoreactivation of growth and DNA synthesis in UV-irradiated cells and photoreactivating-enzyme activity of cell-free extracts can be demonstrated in a cell line derived from liver tissue of the African clawed toad, Xenopus laevis. This cell line, A8W2, is a favorable system for the quantitative study of photoreactivation in vertebrates.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040710208
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  • 5
    Electronic Resource
    Electronic Resource
    Hemopoietic progenitor cells of W anemic mice studied in vivo and in vitroThis investigation was supported by Research grants G-66-RP-5 and G-67-RP-9 from the United Health Foundation of Western New York, and by Research grants CA-08847 and CA-07745 from the U.S. Public Health Service. (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 71 (1968), S. 211-226 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The proliferation and differentiation of hemopoietic cells from genetically anemic Wv/Wx,W/Wv, and Wv/Wv mice, and from nonanemic carrier W/+, Wb/+, and Wv/+ mice have been evaluated in vivo by transplantation techniques and in vitro by the agar gel culture method. Marrow from anemic and carrier mice contained progenitor cells which were decreased in number and formed small, often rudimentary, colonies in the spleens of irradiated recipient mice. Proliferation and differentiation of both erythropoietic and leukopoietic progenitor cells were delayed and reduced, but erythropoiesis was more severely affected than leukopoiesis. The severity of the hemopoietic impairment was gene-dose dependent. The W gene effect on leukopoietic progenitor cells was not secondary to anemia or to abnormal erythropoiesis.The marrow cells of anemic and carrier mice which form colonies of granulocytic and mononuclear cells in vitro were neither decreased in number nor impaired in proliferation and differentiation. Hypertransfusion of red blood cells increased the frequency of in vitro colony-forming cells, but not that of in vivo progenitor cells.The data demonstrate that colony-forming cells which proliferate in the agar gel cultures in vitro are distinct from the in vivo colony-forming cells and suggest that the former are primitive members of the granulocytic cell line. Perhaps in vitro CFU are in an intermediate stage of differentiation between in vivo CFU and myeloblasts, analogous to that which has been suggested for the erythropoietin-sensitive cell in the red cell series. W mutant alleles appear to act, therefore, at or very near the beginning of hemopoietic differentiation.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040710304
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  • 6
    Electronic Resource
    Electronic Resource
    The metabolism of pyrimidine compounds by Tetrahymena pyriformisSupported by NSF grant GB-1635 (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 72 (1968), S. 173-183 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The pyrimidine requirements for growth of T. pyriformis and for reversal of the growth inhibition caused by folate deprivation have been studied. The effects of thymidine and 5-fluorodeoxyuridine have been shown to be quantitatively different from the effects of these compounds on growth and the rate of DNA synthesis in mammalian cells. Labelled nucleosides added to the medium have been found to be converted to the corresponding bases with the exception of deoxycytidine, which is first deaminated to deoxyuridine. As a result no deoxynucleosides other than thymidine specifically label DNA.The results allow deductions to be made concerning the enzymes involved in pyrimidine utilization by this organism. It is suggested that pyrimidine utilization is always channeled through uracil in the case of those compounds that can supply the pyrimidine requirement for growth.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040720305
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  • 7
    Electronic Resource
    Electronic Resource
    Factors influencing hematopoietic spleen colony formation in irradiated mice. V. Effect of foreign plasma upon colony forming cell kineticsThis investigation was supported by a research grant AM-04489 and a graduate training grant 2A-5098 from the National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, Maryland. (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 71 (1968), S. 227-238 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Foreign plasma injection induces a profound and somewhat complex change in the size and location of the colony forming unit (CFU) cell compartment. Injection of foreign plasma before irradiation induces an increase in CFU cells as judged by endogenous colonies as well as by a modification of the endogenous method which excludes spleen colony formation from in situ spleen cells. However, the enlargement does not take place in the most populous CFU cell areas, the spleen and marrow. The concentration and/or total number of CFU cells in spleen and marrow was not increased by plasma injection whether judged by the number of transplantable cells or by the number of migrating endogenous cells.These studies emphasize the complexity of this cellular system and suggest that the use of but one type of stem cell assay may yield results which do not reflect changes within the total compartment. Evidence for cell damage in vitro as a factor influencing results in studies involving transplantation was searched for but was not forthcoming.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040710305
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of phenethyl alcohol on yeast cells (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 72 (1968), S. 97-107 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: An investigation of the physiological effects of phenethyl alcohol (PEA) on exponentially growing yeast cells is reported. RNA, DNA, protein and aminoimidazole ribotide syntheses and glucose uptake and incorporation are inhibited by PEA at concentrations of 0.1% to 0.3%. Two classes of response curves are found and the sensitivities of processes in each class to PEA differ. Glucose incorporation and RNA synthesis are the most sensitive processes in their respective classes. The effects of PEA at 0.3% or less are largely or completely reversible. It is deduced that PEA inhibits intracellular processes as well as the cell membrane.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040720204
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  • 9
    Electronic Resource
    Electronic Resource
    Monocyte kinetics: Observations after pulse labelingSupported by a research grant from the Medical Research Council of Canada. (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 72 (1968), S. 65-71 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Because monocytes and their precursors cannot be recognized with certainty in tissues, an approach to the study of monocyte kinetics was made through examination of the peripheral blood. Injection of a single pulse of tritiated thymidine into rats resulted in the appearance of labeled monocytes identified as circulating peroxidase-positive mononuclear cells. The increase in the percent of labeled cells and in the mean grain count per cell followed a course described by a mathematical model with a generation time of 21 hours and a DNA synthesis time of 12.5 hours. The generation and synthesis times appear to be very uniform for the monocyte so that the phasing of cells represented by the uptake of label could be followed for more than two generations, a property not shared by neutrophils or lymphocytes. Monocytes appear in the circulation within eight hours of DNA synthesis.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040720111
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  • 10
    Electronic Resource
    Electronic Resource
    Regulation of specific protein synthesis in cytodifferentiationThis research was supported in part by U. S. Public Health Service Grant HD-02126, National Science Foundation Research Grant GB-4273, and American Cancer Society Grant PF-436 (to R.A.R.). (1968)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 72 (1968), S. 1-18 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The developmental features of the pancreas are reviewed as an example of cytodifferentiation and organogenesis. Attention is directed to the regulatory characteristics of the specific proteins synthesized and secreted by the endocrine and exocrine cells. The following topics are discussed: (1) number of specific protein species and, inferentially, the number of genes involved in differentiated function. (2) The stringent regulation of the concentration of these specific proteins and the probable restriction of their synthesis to exocrine and endocrine cells. (3) The multiphasic pattern of accumulation of these specific proteins during pancreatic development and the synchronized but noncoordinate regulation of individual protein species. Synthetic rates of specific exocrine proteins in vitro correlate closely with measurements of the accumulation of proteins during development. (4) A model postulating three regulatory transitions. The primary transition (related to organ “determination”) denotes the conversion of a “predifferentiated” cell to the “protodifferentiated” state in which low but significant levels of specific proteins are present. The secondary transition is viewed as an amplification of this specific protein synthesis and is associated with typical pancreatic histogenesis. In the third regulatory transition, the synthesis of specific proteins in the “differentiated state” is modulated by diet, or hormonal states, etc. The third regulatory transition may be similar to some types of “enzyme induction” as studied in multicellular systems. (5) The differentiative fidelity in an organotypic culture system; the role of mesenchymal tissue or a particle fraction derived therefrom in supporting the protodifferentiated state and the secondary regulatory transition. (6) The possible mechanisms of the secondary regulatory transition in exocrine cells. Effects of actinomycin D, bromodeoxyuridine, and other mitotic inhibitors suggest the requirement for a critical cell division prior to the loss of proliferative capacity. (7) The synthesis of pro-insulin and insulin during primary and secondary regulatory transitions; the possible interrelationships of endocrine and exocrine cells in pancreas development.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1040720403
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