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  • 1
    Signatur: K 97.0066 ; K 97.0067
    In: Geologische Karte der Deutschen Demokratischen Republik
    Seiten: 77x57 cm
    Ausgabe: 1. Aufl.
    Sprache: Deutsch
    Zweigbibliothek: GFZ Bibliothek
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Schriftenreihen ausleihbar
    Schriftenreihen ausleihbar
    Ottawa : Geological Survey of Canada
    Dazugehörige Bände
    Signatur: SR 90.0007(163)
    In: Bulletin
    Materialart: Schriftenreihen ausleihbar
    Seiten: 38 S.
    Serie: Bulletin / Geological Survey of Canada 163
    Sprache: Englisch
    Standort: Kompaktmagazin unten
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Schriftenreihen ausleihbar
    Schriftenreihen ausleihbar
    Ottawa : Geological Survey of Canada
    Dazugehörige Bände
    Signatur: SR 90.0008(67-63)
    In: Paper
    Materialart: Schriftenreihen ausleihbar
    Seiten: VIII, 51 S. + 6 pl.
    Serie: Paper / Geological Survey of Canada 67-63
    Sprache: Englisch
    Standort: Kompaktmagazin unten
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Schriftenreihen ausleihbar
    Schriftenreihen ausleihbar
    Washington, DC : United States Gov. Print. Off.
    Dazugehörige Bände
    Signatur: SR 90.0002(584-B)
    In: Professional paper
    Materialart: Schriftenreihen ausleihbar
    Seiten: III, B-27 S.
    Serie: U.S. Geological Survey professional paper 584-B
    Sprache: Englisch
    Standort: Kompaktmagazin unten
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Signatur: MOP 45152
    Materialart: Monographie ausleihbar
    Seiten: 16 S.
    Standort: MOP - Bitte bestellen
    Zweigbibliothek: GFZ Bibliothek
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Biophysics. ; Cell interaction. ; Biomedical engineering. ; Cardiovascular system. ; Physiology. ; Cardiography. ; Molecular biology. ; Clinical biochemistry. ; Mechanobiological Cell Signaling. ; Biomedical Engineering and Bioengineering. ; Cardiovascular Physiology. ; Cardiography. ; Molecular Biology. ; Medical Biochemistry.
    Beschreibung / Inhaltsverzeichnis: Part 1: Cardiac Signaling -- Chapter 1: Calcium-Dependent Signaling in Cardiac Myocytes -- Chapter 2: Organization of Ca2+ Signaling Microdomains in Cardiac Myocytes -- Chapter 3: Stress Kinase Signaling in Cardiac Myocytes -- Chapter 4: Cardiotoxicity and cardiac cell signaling -- Chapter 5: Protein Phosphatase Signaling in Cardiac Myocytes -- Chapter 6: Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function -- Chapter 7: NADPH Oxidase System Mediates Cholesterol Secoaldehyde-Induced Oxidative Stress and Cytotoxicity in H9c2 Cardiomyocytes -- Chapter 8: Lipid Mediators in Cardiovascular Physiology and Disease -- Chapter 9: Cardiac Inflammasome and Arrhythmia -- Chapter 10: Myocardial Fibrosis: Cell Signaling and In Vitro Modeling -- Chapter 11: Neural regulation of cardiac rhythm -- Part 2: Vascular Signaling -- Chapter 12: Mechanisms of lipoproteins and reverse cholesterol transport in atherosclerotic cardiovascular disease -- Chapter 13: Atherosclerotic plaque regression: Future perspective -- Chapter 14: Role of Bioactive Lipid, Phosphatidic Acid in Hypercholesterolemia Drug-induced Myotoxicity – Statin-induced Phospholipase D (PLD) Lipid Signaling in Skeletal Muscle Cells -- Chapter 15: Cell-Cell Communication in the Vascular Endothelium -- Chapter 16: Lysophosphatidic acid regulates endothelial barrier integrity -- Chapter 17: Regulation of Vascular Endothelial Barrier Integrity and Function by Lipid-Derived Mediators -- Chapter 18: Hyperglycemic Oxoaldehyde (Glyoxal)-induced Vascular Endothelial Cell Damage through Oxidative Stress is protected by Thiol Iron Chelator, Dimercaptosuccinic Acid – Role of Iron in Diabetic Vascular Endothelial Dysfunction.
    Kurzfassung: This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases. This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.
    Materialart: Online-Ressource
    Seiten: XVIII, 527 p. 83 illus., 59 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031083099
    DDC: 571.4
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Schlagwort(e): Medical sciences. ; Radiology. ; Neurology . ; Health Sciences. ; Radiology. ; Neurology.
    Beschreibung / Inhaltsverzeichnis: The subcortical space: anatomy of the subcortical white matter -- Common pathology of the subcortical region -- The ventricular system: Anatomy and common lesions -- Advanced neuro-imaging of the subcortical space -- Advanced neuro-imaging of the human ventricular system -- The evolution of trans-sulcal, channel-based parafascicular surgery -- Open transcortical approaches to subcortical lesions -- Traditional open and neuro-endoscopic approaches to intraventricular pathology -- Trans-sulcal, channel-based parafascicular surgery: Technological considerations and instrumentation -- Standard parafascicular approaches to subcortical regions -- Trans-sulcal, channel-based parafascicular surgery: Basic concepts and a general overview -- Trans-sulcal, channel-based parafascicular surgery for brain metastases -- Trans-sulcal, channel-based parafascicular surgery for gliomas and other primary, intrinsic subcortical tumors -- Trans-sulcal, channel-based parafascicular biopsy techniques -- Trans-sulcal, channel-based parafascicular surgery for intraventricular lesions -- Trans-sulcal, channel-based parafascicular surgery for intracerebral hematoma (ICH) -- Trans-sulcal, channel-based parafascicular surgery for cavernous angiomas and other vascular lesions -- Trans-sulcal, channel-based parafascicular surgery for tumors; Adjunctive measures and techniques -- Case selection and surmounting the learning curve -- Future directions.
    Kurzfassung: This book will be the definitive reference on surgery of the subcortical region. It comprehensively discusses all aspects of treatment of subcortical and intraventricular lesions, including neuroanatomy and neuroimaging of the subcortical space, principles of parafascicular subcortical channel-based surgery, common indications and approaches, and focused chapters for common subcortical lesions. The first section of the reference focuses on the intricate anatomy and neuro-imaging of the subcortical space and ventricular system, with special emphasis on intricate white matter tracts and diffusion tractography imaging. The next section of the book discusses principles of both open and parafascicular, channel-based approaches to subcortical and intraventricular lesions, in addition to workhorse approaches to common subcortical compartments. Finally, specific pathological subcortical lesions that can be commonly addressed via parafascicular channel-based approaches, including brain metastases, gliomas, and intracerebral hemorrhage are addressed. Authored by experts in the field of subcortical neurosurgery, this book was developed to provide a unique, comprehensive text for neurosurgeons, neuro-radiologists, and trainees from a variety of specialties interested in evolving minimally disruptive access and treatment of the subcortical space.
    Materialart: Online-Ressource
    Seiten: XII, 257 p. 94 illus., 72 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030951535
    DDC: 610
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Microbiology. ; Microbial ecology. ; Evolution (Biology). ; Microbiology. ; Microbial Ecology. ; Evolutionary Biology.
    Beschreibung / Inhaltsverzeichnis: PART I. Viral Control of Community Energetics -- Chapter 1. Viral Nature of the Aquatic Ecosystems -- Chapter 2. Life Continues as Viruses Close Land, Water and Atmosphere Nutrient Cycle -- PART II. Understanding the Genetic Partnership Between a Host and Its Viruses -- Chapter 3. Cataloging the Presence of Endogenous Viruses -- Chapter 4. Do the Biological Roles of Endogenous and Lysogenous Viruses Represent Faustian Bargains? -- Chapter 5. Einstein's Capsid: Bacteriophages Solve the Problems of Space and Time for Bacteria with Emergency Dead to Alive Horizontal Gene Transfer (EDA-HGT) -- Chapter 6. Diverse Phage-Encoded Toxins and Their Role in Bacterial Ecology -- Chapter 7. Mycoviruses as Antivirulence Elements of Fungal Pathogens -- PART III. Defending the Health of Its Hosts -- Chapter 8. The Contribution of Viruses to Immune Systems -- Chapter 9. Application of Viruses for Gene Therapy and Vaccine Development -- Chapter 10. Eukaryotic Virus Interactions with Bacteria: Implications for Pathogenesis and Control.
    Kurzfassung: This book answers the question “What is it that viruses do?” by presenting three aspects of viral ecology. The first aspect explains how viruses affect the population diversity and energetics of their host communities. Perhaps the most notable example of this concept is our understanding that primary production within ecosystems often depends upon those viruses which serve as controllers of nutrient recycling, connecting the aquatic and terrestrial realms in ways that can be assessed locally and globally. The second aspect describes genetic partnerships which exist between hosts and their viruses. These include processes termed endogeny and lysogeny by which the host carries at least a partial genomic copy of the virus. Fluidity of these collective genomes is expressed on an evolutionary time scale and the mutual life cycles which they produce represent a forging of shared genomic fate that obligates partnership of the virus and its host. The viral sequences represent a source of potential benefit as well as potential peril for the host and can implement phenotypic changes in the host. Hosts often use those changes as tools. As humans, the most notable example would be that mammals rely upon temporary activation of their endogenous viral genes in order to successfully develop a placenta. The third aspect is defending the health of a host, which relies upon activity in two directions. Hosts often use their captured viral genes to identify and subsequently direct battle against invading viruses. This natural concept has been engineered for combating cancer, is useful for suppressing the detrimental consequences of genetic diseases, and has been developed to create targeted antiviral vaccines. But, the defense has to work in two directions and the host can use other symbiotic microorganisms as protection against its viruses. This book will appeal to a wide readership by providing a broad perspective of viral ecology, and all scientists will find it helpful for gaining a view of fields beyond their specialization.
    Materialart: Online-Ressource
    Seiten: XVI, 367 p. 28 illus., 25 illus. in color. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783030853952
    Serie: Advances in Environmental Microbiology, 9
    DDC: 579
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Proteins . ; Biomolecules. ; Physical biochemistry. ; Macromolecules. ; Cytology. ; Protein Biochemistry. ; Structural Biology. ; Cell Biology.
    Beschreibung / Inhaltsverzeichnis: Part 1: Soluble Protein Complexes -- Chapter 1: Fatty Acid Synthase: Structure, Function, and Regulation -- Chapter 2: ATP-binding cassette transporters: Snap-on complexes? -- Chapter 3: The Fork Protection Complex: A regulatory hub at the head of the replisome -- Chapter 4: Ferritin-like Proteins: A Conserved Core for a Myriad of Enzyme Complexes -- Chapter 5: Still no rest for the reductases: Ribonucleotide reductase (RNR) Structure and Function — an update -- Chapter 6: Structure and Dynamics of the Human Multi-tRNA Synthetase Complex -- Chapter 7: On the regulation of mitosis by the kinetochore, a macromolecular complex and organising hub of eukaryotic organisms -- Part 2: Membrane Protein Complexes -- Chapter 8: The conformational dynamics of heterotrimeric G proteins during GPCR-mediated activation -- Chapter 9: Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome -- Chapter 10 : Structure, Function, and Regulation of the Kainate Receptor -- Chapter 11: Structure, function and variations of the photosystem I-antenna supercomplex from different photosynthetic organisms -- Chapter 12: Structure and Function of Mycobacterial Arabinofuranosyltransferases -- Part 3: Fibrous Protein Complexes -- Chapter 13: Structure and assembly of the bacterial flagellum -- Chapter 14: Actomyosin Complex -- Chapter 15: Structure of motile cilia -- Chapter 16: Segment-Long-Spacing (SLS) and the Polymorphic Structures of Fibrillar Collagen -- Part 4: Virus Protein Complexes -- Chapter 17: Viral Capsid and Polymerase in Reoviridae.
    Kurzfassung: This book covers the latest findings of a wide variety of viral, prokaryotic and eukaryotic macromolecular protein complexes and builds upon the solid macromolecular foundations established by previous volumes of the Subcellular Biochemistry series. Thus, an almost encyclopaedic coverage of the broad field of protein complex structure and function has been established. The 17 interesting chapters included in this book have been organised into four sections: Soluble Protein Complexes, Membrane Protein Complexes, Fibrous Protein Complexes and Viral Protein Complexes. Significant topics present here are: Fatty Acid Synthase, the Fork Protection Complex, Ribonucleotide Reductase, the Kinetochore, G proteins, the FtsEX Complex, the Kainate Receptor, the Photosystem I-antenna, the Mycobacterial Arabinofuranosyltransferases, the the Bacterial Flagellum, the Actomyosin Complex, Motile Cilia, SLS Collagen Polymorphic Structures, and the Reovirus Capsid and Polymerase. Up-dates/expansion of chapter topics present in earlier volumes are now included in chapters here, e.g., those on Ferritin-like proteins and the Multi-tRNA Synthetase. The book is richly illustrated throughout, which is the result of an impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy. Functional aspects of protein-protein interactions are also given a high priority.
    Materialart: Online-Ressource
    Seiten: VIII, 552 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031007934
    Serie: Subcellular Biochemistry, 99
    DDC: 572.6
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Cham :Springer International Publishing :
    Schlagwort(e): Medicine Research. ; Biology Research. ; Molecular biology. ; Metabolism. ; Genetics. ; Cytology. ; Biomedical Research. ; Molecular Biology. ; Metabolism. ; Genetics and Genomics. ; Cell Biology.
    Beschreibung / Inhaltsverzeichnis: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.
    Kurzfassung: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
    Materialart: Online-Ressource
    Seiten: XII, 346 p. 1 illus. , online resource.
    Ausgabe: 1st ed. 2022.
    ISBN: 9783031118364
    Serie: Advances in Experimental Medicine and Biology, 1390
    DDC: 610.72
    Sprache: Englisch
    Standort Signatur Erwartet Verfügbarkeit
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