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  • American Society of Hematology  (1)
  • Nature Publishing Group  (1)
  • 1975-1979
  • 1965-1969  (2)
  • 1966  (2)
  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 210 (1966), S. 1064-1066 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A prime difficulty in investigating Heinz bodies has been the absence of methods for quantitative evaluation. Most research workers simply estimated the number and size of granules observed under the light microscope4'5. Beutler et al.6, in their study of Heinz body formation during exposure of ...
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 1966-09-01
    Description: Levels of erythropoietin have been consistently demonstrated in urine collections from healthy adult males using a modification of the polycythemic mouse assay. This method is stable and reproducible, and it provides assay animals with low background erythropoiesis. Six hour collections of urine can be concentrated without apparent loss of activity and the entire daily excretion can be used in the assay. Quantitation has been achieved by comparing the response to a concentrate of normal urine directly to a linear dose/response curve of erythropoietin standard B. Based on 6 hour urine collections, erythropoietin excretion in the subjects tested averaged 4.0 units of erythropoietin standard B (range 1.2-9.5). In addition to wide unexplained variations in results seen from day to day, the data indicate that a diurnal pattern of excretion of the hormone may exist.
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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