Publication Date:
1993-01-01
Description:
During development, motion of nerve growth cones ceases on contact with particular targets. The signaling mechanism is unknown. In culture, growth cone collapse can be caused by solubilized embryonic brain membranes, central nervous system myelin, a 35-kilodalton protein isolated from myelin, and mastoparan. Collapse induced by each of these is blocked by pertussis toxin. Thus, collapse of growth cones is mediated by G protein-coupled receptors, which may be activated by proteins associated with the cell surface as well as by soluble ligands.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Igarashi, M -- Strittmatter, S M -- Vartanian, T -- Fishman, M C -- New York, N.Y. -- Science. 1993 Jan 1;259(5091):77-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Developmental Biology Laboratory, Massachusetts General Hospital-East, Charlestown 02129.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8418498" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/*physiology
;
Cell Membrane/drug effects/physiology/ultrastructure
;
Chick Embryo
;
GTP-Binding Proteins/*metabolism
;
Ganglia, Spinal/*physiology
;
Myelin Proteins/physiology
;
Neurons/drug effects/*physiology/ultrastructure
;
Organ Culture Techniques
;
Peptides
;
Pertussis Toxin
;
*Signal Transduction
;
Virulence Factors, Bordetella/pharmacology
;
Wasp Venoms/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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