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  • 1
    Electronic Resource
    Electronic Resource
    Liver autophagy in the influenza B virus model of Reye's syndrome in mice (1986)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 31 (1986), S. 271-275 
    Details
    ISSN: 0730-2312
    Keywords: Reye's syndrome ; liver autophagy ; influenza B virus ; ornithine carbamoyl transferase ; glucose-6-phosphatase ; tritosomes ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Biochemical evidence is presented for the autophagic destruction of liver mitochondria in the influenza B virus model of Reye's syndrome in mice. Separation of lysosomes and autophagic vacuoles from mitochondria was accomplished by prior treatment of the mice with Triton WR-1339, resulting in uptake of detergent by these organelles (tritosomes), reducing their densities. The organelles were banded in a discontinuous sucrose gradient. Total protein in the heavy tritosomal fraction increased from 1-2% in controls to 7-8% in virus-treated animals. Ornithine carbamoyl transferase (OCTase), a mitochondrial marker, increased from 2-3% (controls) to 11-15% (virus-treated), and glucose-6-phosphatase, a marker for endoplasmic reticulum, increased from 1-2% (controls) to 8-10% (virus-treated). β-Galactosidase, a soluble enzyme in the lysosome, and OCTase also increase in the cell extract fraction following virus treatment, indicating that there was turnover of heavy lysosomal contents.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240310404
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The amdS gene of Aspergillus nidulans: Control by multiple regulatory signals (1986)
    New York, NY : Wiley-Blackwell
    BioEssays 5 (1986), S. 123-128 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The amdS gene of A. nidulans has proved extremely favourable for the isolation of mutations affecting gene regulation. Trans-acting regulatory genes involved in amdS induction by small molecular weight effectors have been identified - amdR (ω-amino acids) facB (acetate) and amdA (acetate). Another gene, the areA gene, has properties expected of a major activator gene involved in nitrogen metabolite repression of amdS. All of these regulatory genes are also involved in the control of various other functions encoded by structural genes unlinked to amdS. Mutations in the 5′-region adjacent to amdS have been isolated and allow the identification of independent cis-acting sequences which are the target sites for the regulatory genes. The involvement of these sequences in regulatory product binding has been deduced from titration studies using transformants containing multiple copies of the 5′ sequences. A combination of genetics and molecular analysis is allowing a detailed characterization of this system.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950050308
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  • 3
    Electronic Resource
    Electronic Resource
    Toward an understanding of liposome structure through the use of computer graphic image correlation (1986)
    New York, NY : Wiley-Blackwell
    Journal of Electron Microscopy Technique 3 (1986), S. 385-400 
    Details
    ISSN: 0741-0581
    Keywords: Freeze fractures ; Vesicles ; Liquid crystal ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Natural Sciences in General
    Notes: A computer-aided graphics approach to correlating transmission electron microscope images of freeze-fractured and thin-sectioned samples is outlined. Any three-dimensional model of the imaged structure can be mathematically sectioned to provide a two-dimensional representation of the model in the “fracture” plane. The method is used to demonstrate that the structure of lamellar liquid crystalline liposomes is based on a family of Dupin cyclides; closed, parallel surfaces with a conjugate ellipse and hyperbola as curvature defects.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jemt.1060030403
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  • 4
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    Immunization with an isolate-common surface protein protects cattle against anaplasmosis (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-03-14
    Description: Hemoparasitic diseases are endemic in half the world's livestock production areas and are the greatest obstacle to improved meat, milk, and fiber production in the Third World. The most prevalent of these diseases, anaplasmosis, occurs throughout tropical and subtropical regions and is responsible for 50,000 to 100,000 cattle deaths annually in the United States alone. Despite its prevalence and the severity of the losses, an effective immunoprophylaxis for anaplasmosis has not been developed. A neutralization-sensitive epitope on a surface protein with a molecular weight of 105,000 (Am 105) of the causative rickettsia Anaplasma marginale was identified by monoclonal antibody inhibition of infectivity. This epitope was determined to be common to eight isolates with antigenic, morphologic, and protein structural differences. Cattle immunized with Am 105 purified by immunoaffinity chromatography were protected against challenge with virulent Anaplasma marginale. The identification of Am 105 as bearing isolate-common epitopes capable of inducing protection in immunized cattle provides the basis for the development of an effective subunit vaccine for bovine anaplasmosis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Palmer, G H -- Barbet, A F -- Davis, W C -- McGuire, T C -- GM 07853/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1986 Mar 14;231(4743):1299-302.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3945825" target="_blank"〉PubMed〈/a〉
    Keywords: Anaplasma/immunology ; Anaplasmosis/immunology/*prevention & control ; Animals ; Antibodies, Monoclonal ; Antigens, Surface/*immunology/isolation & purification ; Cattle ; Cattle Diseases/immunology/parasitology/*prevention & control ; Chromatography, Affinity ; Electrophoresis, Polyacrylamide Gel ; Immunization/*veterinary ; Plasmodium/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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