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Digitale Medien

Liver autophagy in the influenza B virus model of Reye's syndrome in mice (1986)

Woodfin, Beulah M. ; Davis, Larry E.

New York, N.Y. : Wiley-Blackwell

Journal of Cellular Biochemistry 31 (1986), S. 271-275

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ISSN: 0730-2312

Schlagwort(e): Reye's syndrome ; liver autophagy ; influenza B virus ; ornithine carbamoyl transferase ; glucose-6-phosphatase ; tritosomes ; Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Chemie und Pharmazie , Medizin

Notizen: Biochemical evidence is presented for the autophagic destruction of liver mitochondria in the influenza B virus model of Reye's syndrome in mice. Separation of lysosomes and autophagic vacuoles from mitochondria was accomplished by prior treatment of the mice with Triton WR-1339, resulting in uptake of detergent by these organelles (tritosomes), reducing their densities. The organelles were banded in a discontinuous sucrose gradient. Total protein in the heavy tritosomal fraction increased from 1-2% in controls to 7-8% in virus-treated animals. Ornithine carbamoyl transferase (OCTase), a mitochondrial marker, increased from 2-3% (controls) to 11-15% (virus-treated), and glucose-6-phosphatase, a marker for endoplasmic reticulum, increased from 1-2% (controls) to 8-10% (virus-treated). β-Galactosidase, a soluble enzyme in the lysosome, and OCTase also increase in the cell extract fraction following virus treatment, indicating that there was turnover of heavy lysosomal contents.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jcb.240310404

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Digitale Medien

Aporphines 65For Part 64, see Ref. 1.: Chemical, microbial synthesis and characterization by gas chromatography/mass spectrometry of (R)-(-)-10-hydroxy 11-methoxy-N-n-propylnoraporphine, a potential metabolite of N-n-propylnorapomorphine (1986)

Neumeyer, John L. ; Abdel-Maksoud, Hamdy M. ; Trainor, Thomas M. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 13 (1986), S. 223-229

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The title compound has been synthesized by a multistep sequence from (R)(-)-morphine, and compared with the product obtained by microbial O-demethylation of (R)- and (S)-10,11-dimethoxy-N-n-propylnoraporphine (N-n-propylnorapomorphine dimethyl ether). The comparison was based on an analysis of the trifluoroacetyl derivatives of the microbial products and the synthesized compounds using gas chromatography/mass spectrometry in the electron impact mode. Examination by gas chromatography/electron impact/mass spectrometry of the trifluoroacetyl derivatives of 11-hydroxy-10-methoxyaporphine (apocodeine, 3) and 10-methoxy-11-hydroxyaporphine (isoapocodeine, 5) has revealed their excellent chromatographic resolution, and the preferential loss of the methyl group as in 3 [M - 15]+ or the trifluoroacetyl group from the 10-position of the aporphine ring as in 5 [M - 97]+. Characteristic fragmentations of the these isomeric aporphines were used to confirm their structures and were compared with the spectra of authentic synthetic samples.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200130504

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Digitale Medien

The amdS gene of Aspergillus nidulans: Control by multiple regulatory signals (1986)

Hynes, Michael J. ; Davis, Meryl A.

New York, NY : Wiley-Blackwell

BioEssays 5 (1986), S. 123-128

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ISSN: 0265-9247

Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Medizin

Notizen: The amdS gene of A. nidulans has proved extremely favourable for the isolation of mutations affecting gene regulation. Trans-acting regulatory genes involved in amdS induction by small molecular weight effectors have been identified - amdR (ω-amino acids) facB (acetate) and amdA (acetate). Another gene, the areA gene, has properties expected of a major activator gene involved in nitrogen metabolite repression of amdS. All of these regulatory genes are also involved in the control of various other functions encoded by structural genes unlinked to amdS. Mutations in the 5′-region adjacent to amdS have been isolated and allow the identification of independent cis-acting sequences which are the target sites for the regulatory genes. The involvement of these sequences in regulatory product binding has been deduced from titration studies using transformants containing multiple copies of the 5′ sequences. A combination of genetics and molecular analysis is allowing a detailed characterization of this system.

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bies.950050308

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An EPR study of the thermal decomposition of molten 2,4,6-trinitrotoluene and its isotopic analogs (1986)

Swanson, Jon T. ; Davis, Larry P. ; Dorey, R. Cameron ; [weitere]

Chichester : Wiley-Blackwell

Organic Magnetic Resonance 24 (1986), S. 762-767

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ISSN: 0749-1581

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Electron paramagnetic resonance spectroscopy has been used to probe the decomposition pathway of neat molten 2,4,6-trinitrotoluene (TNT). The analogs of TNT labelled in the 2-, 2,6-, 4- and 2,4,6-positions with 15N, and labelled in the α-, 3,5- and α,3,5-position with 2H have been studied, and their spectra recorded at 240°C. The results indicate that the earliest observable radical produces a spectrum resulting from coupling with a para-N (aN = 10.8G), five equivalent hydrogens (aH = 2.7G) and two benzylic hydrogens (aH = 10.7G).

Zusätzliches Material: 8 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/mrc.1260240906

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Toward an understanding of liposome structure through the use of computer graphic image correlation (1986)

Zasadzinski, Joseph A. N. ; Kerins, John ; Davis, H. T. ; [weitere]

New York, NY : Wiley-Blackwell

Journal of Electron Microscopy Technique 3 (1986), S. 385-400

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ISSN: 0741-0581

Schlagwort(e): Freeze fractures ; Vesicles ; Liquid crystal ; Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Allgemeine Naturwissenschaft

Notizen: A computer-aided graphics approach to correlating transmission electron microscope images of freeze-fractured and thin-sectioned samples is outlined. Any three-dimensional model of the imaged structure can be mathematically sectioned to provide a two-dimensional representation of the model in the “fracture” plane. The method is used to demonstrate that the structure of lamellar liquid crystalline liposomes is based on a family of Dupin cyclides; closed, parallel surfaces with a conjugate ellipse and hyperbola as curvature defects.

Zusätzliches Material: 8 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jemt.1060030403

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