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  • correlation analysis  (2)
  • Chemistry
  • General Chemistry
  • Gonadotrops
  • Granules
  • Liquid chromatography
  • Magnetism
  • Seismology
  • Springer  (4)
  • 2000-2004  (2)
  • 1980-1984  (2)
  • 1955-1959
  • 1940-1944
  • 1935-1939
  • 2000  (2)
  • 1983  (2)
  • 1959
  • 1943
Collection
Keywords
Publisher
Years
  • 2000-2004  (2)
  • 1980-1984  (2)
  • 1955-1959
  • 1940-1944
  • 1935-1939
Year
  • 1
    Electronic Resource
    Electronic Resource
    The brain-pituitary-gonadal axis in the rainbow trout, Salmo gairdneri (1983)
    Springer
    Cell & tissue research 233 (1983), S. 377-388 
    Details
    ISSN: 1432-0878
    Keywords: Gonadotrops ; Gonadotropin secretion ; Steroids ; Brain-pituitary-gonadal axis ; Juvenile teleost
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In a cytophysiological study it was investigated whether in juvenile trout gonadal steroids stimulate the gonadotropic (GTH)-cells directly or indirectly via the brain. Pituitaries of donor animals were transplanted into the caudal musculature of testosterone-treated and non-testosterone-treated host fish. Testosterone treatment caused an increase in GTH-content in the in situ pituitaries and in the grafts. Accordingly, the gonadotrops displayed ultrastructural changes such as the appearance of well-developed Golgi systems and large globules. The stimulation of the morphological development of gonadotrops and of synthesis and storage of GTH in the allografted pituitaries indicates that testosterone affects the GTH-cells directly. In untreated juvenile trout the gonadotropin content of the pituitary and the gonadotropin concentration in the plasma vary with the time of year. This variation and the role of testosterone and gonadotropin-releasing hormone on the release of GTH are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238304
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  • 2
    Electronic Resource
    Electronic Resource
    Predicting the Free Energies of Complexation Between Cyclodextrins and Guest Molecules: Linear versus Nonlinear Models (2000)
    Springer
    Pharmaceutical research 17 (2000), S. 358-365 
    Details
    ISSN: 1573-904X
    Keywords: QSPR, Quantitative Structure-Property Relationship ; correlation analysis ; regression models ; molecular modeling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. In the present paper, linear and nonlinear models forcomplexation of α- β- and γ-cyclodextrin with guest molecules are developed,with the aim of free energy prediction and interpretation of theassociation process. Methods. Linear and nonlinear regression is used to correlateexperimental free energies of complexation with calculated moleculardescriptors. Molecular modeling supports the interpretation of the results. Results. Highly predictive models are obtained, although the structuralvariability of the compounds used for their deduction is large, reachingfrom synthetic heterocycles to steroids and prostaglandins. Conclusions. The scaled regression coefficients give insight to thecomplexation mechanisms, which appear to be different for the threetypes of cyclodextrins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007565409407
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  • 3
    Electronic Resource
    Electronic Resource
    A Method for Predicting the Free Energies of Complexation between β-Cyclodextrin and Guest Molecules (2000)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 36 (2000), S. 409-423 
    Details
    ISSN: 1573-1111
    Keywords: host-guest systems ; linear regression ; molecular descriptors ; statistical models ; correlation analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In the present work, linear regression models for theprediction of the free energies of complexationbetween guest molecules and β-cyclodextrin arededuced. For 70 compounds (mostly pharmaca), theexperimentally determined 1 : 1 stability constants aretransformed into the respective free energies, whichare then correlated with molecular descriptors. The statistically significant descriptors, which leadto models with remarkable predictive power, indicatethat besides volume, shape and lipophilicity, whichhave the largest contribution to the complexationenergy, complexation is also significantly influencedby the flexibility and the hydrogen bonding capacityof the guest molecule.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008063412529
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  • 4
    Electronic Resource
    Electronic Resource
    A comparative study of primary and secondary granules in monocytopoiesis and myelopoiesis of mouse bone marrow (1983)
    Springer
    Cell & tissue research 228 (1983), S. 107-115 
    Details
    ISSN: 1432-0878
    Keywords: Bone marrow (mouse) ; Monocytes ; Neutrophil granulocytes ; Granules ; Electron microscopy ; Peroxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The differentiation and maturation of monocytes and neutrophil granulocytes were studied in bone marrow of normal mice by electron microscopy and cytochemical assessment of peroxidatic activity. The granule populations of the mature cells of bone marrow were identified and investigated to obtain a basis for the analysis of the earlier stages of maturation. Mature monocytes and neutrophils showed primary and secondary granules, and mature neutrophils had more of both kinds. The size, shape, and number of primary granules proved to offer the most reliable criteria for distinguishing promonocytes and promyelocytes. The primary granules of monocytes were smaller than those of mature neutrophils and were either spherical (smallest diameter 50–200 nm) or elongate (100×400 nm). Both granules had a homogeneous matrix. The granules of the granulocytes were either spherical (smallest diameter 200–300 nm) or elongate (150–200×300–500 nm), and some of them had a crystalline inclusion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206269
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