ISSN:
1573-0689
Keywords:
Nitrenium ions
;
DNA base sites
;
interaction energy
;
no calculation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Physics
Notes:
Abstract The ultimate carcinogenic form of aromatic amines, the nitrenium ions, interact with DNA bases in order to exert their carcinogenic effects. Experimental findings have indicated the general trend to produceN (deoxy guanin-8-yl) as the major adduct and the minor adduct involving the extra cyclicN 2 of guanine and the carbon in a β-position of the amine nitrogen. The adduct formation with DNA bases by aromatic amines has been studied with several contributing factors in view. The theoretically computed values of these factors serve as clues to rationalize experimentally observed findings concerning this adduct formation.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00700630
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