Publication Date:
2009-11-20
Description:
Abstract 204 The NIH staging and response criteria offer for the first time the chance for uniform documentation of chronic graft-versus-host disease (cGVHD). Here we present the validation of the cGVHD staging criteria as part of an interim analysis of a prospective German/Austrian multicenter study on the NIH staging criteria in cGVHD. One hundred-seventeen patients (median age 44 years, range 21–72) after allogeneic hematopoietic stem cell transplantation (HSCT) were evaluated according to the NIH criteria based on cGVHD activity assessment including the NIH-cGVHD grading form, the physicians cGVHD activity assessment form, the NIH-cGVHD symptom self assessment form, and the Lee cGVHD symptom-scale (L-cGVHD-SC). Enrolment occurred a median of 443 (range, 100–4003) days after HSCT. The validation of the NIH staging criteria was performed using the first 3 surveys each one month apart. For the purpose of validity a second evaluation was performed including only patients with stable cGVHD (n=64) as judged by the physician (results in parentheses). The statistical significance p was
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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