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  • ASTROPHYSICS  (383)
  • Life and Medical Sciences  (253)
  • Humans  (174)
  • Lunar and Planetary Science and Exploration
  • 2015-2019  (53)
  • 1985-1989  (803)
  • 1930-1934  (9)
  • 2018  (53)
  • 1987  (373)
  • 1986  (430)
  • 1933  (9)
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Keywords
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  • 2015-2019  (53)
  • 1985-1989  (803)
  • 1930-1934  (9)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Differential expression of metastasis-associated cell surface glycoproteins and mRNA in a murine large cell lymphoma (1986)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 31 (1986), S. 305-312 
    Details
    ISSN: 0730-2312
    Keywords: tumor metastasis ; gene expression ; oncogenes ; virus antigens ; glycoproteins ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: A metastatic variant cell subline of the Abelson virus-transformed murine large lymphoma/lymphosarcoma RAW 117 has been selected in vivo ten times for liver colonization. Highly metastatic subline RAW117-H10 forms greater than 200 times as many gross surface liver tumor nodules as the parental line RAW117-P. Analysis of cellular proteins and glycoproteins indicates reduced expression of murine Moloney leukemia virus-associated p15, p30, and gp70, and increased expression of a sialoglycoprotein, gp150, in the highly metastatic H10 cells. Northern analyses of oncogene expression suggested that mRNA of various oncogenes was expressed equally or not expressed in the RAW117 cells of differing metastatic potential. Differential gene expression was examined using a cDNA library of 17,600 clones established from poly A+ mRNA isolated from H10 cells. The cDNA library was screened by the colony hybridization technique using probes made from both RAW117-P and -H10 cells. Approximately 99.5% of these cDNA clones were expressed identically in P and H10 cells. Of the few differentially expressed cDNA clones (approx. 150/17,600), one-half of these were identified as Moloney leukemia virus sequences in a separate probing with a radiolabeled Moloney leukemia virus probe. The remainder of the differentially expressed mRNA detected by colony hybridization of the cDNA library were expressed at higher levels (approx. 1/6) or lower levels (approx. 1/3) in the highly metastatic H10 cells.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240310408
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  • 2
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    Absence of duplication of chromosome 21 genes in familial and sporadic Alzheimer's disease (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-10-30
    Description: The possibility that Alzheimer's disease (AD) is caused by overexpression or duplication of one or more genes on chromosome 21 has been raised by the observation of AD-like neuropathologic changes in individuals with Down syndrome and by the mapping of both the defect for familial AD and the amyloid beta protein gene to this autosome. Possible duplication on chromosome 21 was investigated in both familial and sporadic AD by means of restriction fragment length polymorphisms for the amyloid and SODI loci, as well as for DNA markers in the vicinity of the familial AD defect and in the critical Down syndrome region of chromosome 21. No evidence of increased DNA dosage was observed in either brain or leukocytes of patients with inherited or sporadic forms of AD. Duplication of these regions is therefore not a frequent event in either form of AD. Furthermore, no significant allelic association was detected between AD and any of the loci, including the amyloid and SODI genes, providing no support for the hypothesis that defects in these specific genes are the primary cause of AD.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉St George-Hyslop, P H -- Tanzi, R E -- Polinsky, R J -- Neve, R L -- Pollen, D -- Drachman, D -- Growdon, J -- Cupples, L A -- Nee, L -- Myers, R H -- ADRC P50 AGO5134-02/AD/ADAMHA HHS/ -- NS20012/NS/NINDS NIH HHS/ -- R01 AGO6865-1/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1987 Oct 30;238(4827):664-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Neurogenetics Laboratory, Massachusetts General Hospital, Boston.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2890206" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Alzheimer Disease/*genetics ; Amyloid/genetics ; *Chromosomes, Human, Pair 21 ; Genes ; Genetic Linkage ; Humans ; Polymorphism, Restriction Fragment Length
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Tissue distribution and developmental expression of the messenger RNA encoding angiogenin (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-07-17
    Description: New blood vessel growth occurs during normal fetal development and in diseases such as cancer and diabetes. The polypeptide angiogenin induces new blood vessel growth in two biological assays and may play a role in the vascular development of the fetus and in the neovascularization that accompanies diseases and wound healing. A complementary DNA probe for human angiogenin was used to examine the tissue distribution of angiogenin messenger RNA (mRNA) in the developing rat and in selected transformed cell lines. Angiogenin mRNA was detected predominantly in adult liver but was also detectable at low levels in other tissues. The expression of the angiogenin gene in rat liver was found to be developmentally regulated; mRNA levels were low in the developing fetus, increased in the neonate, and maximal in the adult. The amount of angiogenin mRNA in human HT-29 colon carcinoma and SK-HEP hepatoma cells was not greater than that in normal rat liver. These results demonstrate that angiogenin is predominantly expressed in adult liver, that the pattern of angiogenin gene expression is not temporally related to vascular development in the rat, and that the transformed cells studied do not contain more angiogenin mRNA than does normal liver. If angiogenin activity is controlled at the transcriptional level, the results of this study suggest that the primary function of angiogenin in vivo may be in processes other than the regulation of vascular growth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Weiner, H L -- Weiner, L H -- Swain, J L -- HL26831/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1987 Jul 17;237(4812):280-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2440105" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Animals ; Cell Line ; Gene Expression Regulation ; Humans ; Liver/physiology ; Neoplasm Proteins/*genetics ; Neovascularization, Pathologic ; RNA, Messenger/genetics ; Rats ; *Ribonuclease, Pancreatic ; Tissue Distribution
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-08-22
    Description: A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coussens, L -- Parker, P J -- Rhee, L -- Yang-Feng, T L -- Chen, E -- Waterfield, M D -- Francke, U -- Ullrich, A -- New York, N.Y. -- Science. 1986 Aug 22;233(4766):859-66.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3755548" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Cattle ; Chromosome Mapping ; Chromosomes, Human, 16-18 ; Dna ; Genes ; Humans ; Nucleic Acid Hybridization ; Protein Kinase C/*genetics ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Occultation studies of the solar system (1986)
    In:  CASI
    Details
    Publication Date: 2006-02-14
    Description: Determination of the size, shape, mean density, and albedo of Ceres was made. Predictions for 133 occultations of bright stars occurring in 1986 and 1987 were completed and published, as have predictions of occultations of stars by Comet Halley. Twenty-nine mutual events involving Galilean satellites were observed at Flagstaff in 1985.
    Keywords: ASTROPHYSICS
    Type: NASA, Washington Reports of Planetary Astronomy, 1985; p 108-109
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  • 6
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    The molecular gas in the supernova remnant IC443 (1986)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: Although a few highly perturbed regions characterized by gas motions with velocities larger than 20 km/s have been discovered during the last several years in the supernova remnant (SNR) IC 443, the nature of these perturbed clumps and their relationship to the quiescent molecular gas near the SNR remains unknown. In part, this is due to a lack of large-scale, high angular resolution observations. Therefore, a systematic survey of this SNR in the CO (J=1 yields 0) line has been conducted, covering a roughly 50' x 50' region spaced by 2'. The observations were made with the 14 m telescope of the Five College Radio Astronomy Observatory (FCRAO), which has a resolution of 45" and a single sideband receiver temperature of 200 K at 2.6 mm wavelength. Five new clumps were discovered, bringing the total number of known perturbed regions to eight. To study the physical structure of these clumps in more detail, more complete maps of the clumps have been made in both the CO(J=1 yields 0) and (J=2 yields 1) transitions with the FCRAO telescope. These maps show that the extent of perturbed gas in a typical clump is several arcmin, or a few pc at a distance of 1.5 kpc.
    Keywords: ASTROPHYSICS
    Type: NASA. Ames Research Center Summer School on Interstellar Processes: Abstracts of Contributed Papers; p 69-70
    Format: application/pdf
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  • 7
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    High-Resolution, Ground-Based Observations of the Lunar Sodium Exosphere During the Lunar Atmosphere and Dust Environment Explorer (LADEE) Mission (2018)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: We present the first comprehensive set of lunar exospheric line width and line width derived effective temperatures as a function of lunar phase (66 waxing phase to 79 waning phase). Data were collected between November 2013 and May 2014 during six observing runs at the National Solar Observatory McMath-Pierce Solar Telescope by applying high-resolution Fabry-Perot spectroscopy (R ~ 180,000) to observe emission from exospheric sodium (5,889.9509 , D2 line). The 3-arc min field of view of the instrument, corresponding to ~336 km at the mean lunar distance (384,400 km), was positioned at several locations off the lunar limb; only equatorial observations taken out to 950 km are presented here. We find the sodium effective temperature distribution to be approximately a symmetric function of lunar phase with respect to full Moon. Within magnetotail passage we find temperatures in the range of 2500-9000 K. For phase angles greater than 40deg we find that temperatures flatten out to ~1700 K.
    Keywords: Lunar and Planetary Science and Exploration
    Type: GSFC-E-DAA-TN61679 , Journal of Geophysical Research: Planets (ISSN 2169-9097) (e-ISSN 2169-9100); 123; 9; 2430-2444
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  • 8
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    Characterizing Nanophase Materials on Mars: Spectroscopic Studies of Allophane and Imogolite (2018)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The presence of allophane and other nanophase materials on Mars indicates a time when water was intermittent and short lived. These materials likely represent partially altered or leached basaltic ash and therefore, could represent a geologic marker for where water was present on the Martian surface. Further, they may indicate regions of climate change, where surface water was not present long enough to form clays. Characterization of these materials is important for increasing spectral recognition capacities of our current Martian science array. Ongoing work suggests that variability in the Al:Si ratio of allophane can dictate the amount of both structural and adsorbed water in the crystalline structure.
    Keywords: Lunar and Planetary Science and Exploration
    Type: LPI Contrib. No. 2083-2137 , JSC-E-DAA-TN54276 , Lunar and Planetary Science Conference (LPSC); Mar 19, 2018 - Mar 23, 2018; Woodlands, TX; United States
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  • 9
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    A molecular cloud in the local, hot interstellar medium (1986)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: Echelle spectra recorded at the D lines of Na I are reported for nine A or F stars. Lying at approximate distances ranging from 25 to 230 pc, the stars are projected on or near the high-latitude molecular cloud MBM 12 at l = 159 deg, b = -34 deg. Among a subgroup of five of these stars separated by no more than 1.2 deg on the sky, four which are located at distances d more than 70 pc show strong interstellar D line absorption near the radial velocity of the CO emission observed in this general direction. The fifth star, at roughly 60 pc, shows no detectable absorption. MBM 12 therefore probably lies at roughly 65 pc, within the local region filled primarily by very hot, low-density gas, a conclusion supported by the large internal velocity dispersion of the molecular cloud complex.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters to the Editor (ISSN 0004-637X); 306; L109-L11
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  • 10
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    Infrared cirrus and high-latitude molecular clouds (1986)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: It is established that a close correlation exists between far-infrared cirrus emission observed with IRAS and the CO emission from high-latitude molecular clouds (HCLs). In all cases, the HLCs correspond to the central portions of 100-micron infrared cirrus features. This association firmly establishes at least some of the cirrus as features of the local interstellar medium with typical distances of 100 pc. The infrared energy distribution of the cirrus displays an excess of 12-micron and 25-micron emission over that expected from dust at equilibrium temperature, consistent with emission from very small (less than 10 A) transiently heated grains.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters to the Editor (ISSN 0004-637X); 306; L101-L10
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