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  • ASTROPHYSICS  (74)
  • Humans  (57)
  • Life and Medical Sciences
  • Lunar and Planetary Science and Exploration
  • 1985-1989
  • 1975-1979  (157)
  • 1945-1949
  • 1930-1934  (1)
  • 1925-1929
  • 1978  (157)
  • 1930  (1)
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Schlagwörter
Verlag/Herausgeber
Erscheinungszeitraum
  • 1985-1989
  • 1975-1979  (157)
  • 1945-1949
  • 1930-1934  (1)
  • 1925-1929
Jahr
  • 1
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    Genetically determined sex-reversal in 46,XY humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-10-06
    Beschreibung: Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similiar to those of 45,X women.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉German, J -- Simpson, J L -- Chaganti, R S -- Summitt, R L -- Reid, L B -- Merkatz, I R -- New York, N.Y. -- Science. 1978 Oct 6;202(4363):53-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567843" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Disorders of Sex Development/embryology/*genetics ; Female ; Humans ; Karyotyping ; Male ; Ovary/embryology ; Pedigree ; Sex Chromosome Aberrations/embryology ; Testis/embryology ; Turner Syndrome/embryology/*genetics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    The effect of tobacco smoke on the metabolism and function of rat alveolar macrophagesPresented in part at the 1976 meeting of the American Society for Clinical Investigation (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 95 (1978), S. 105-113 
    Details
    ISSN: 0021-9541
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: Alveolar macrophages harvested by bronchopulmonary lavage from rats exposed to tobacco smoke for 30 days (“smokers”) showed alterations in oxidative metabolism, lactate production and phagocytosis of inert starch particles when compared with control macrophages. Phagocytosis of viable Staphylococcus aureus was unaffected by tobacco smoke. Glucose oxidation measured by conversion of glucose-1-14C to 14CO2 was moderately affected while oxidation of glucose-6-14C to 14CO2 was not. Smokers routinely yielded fewer cells than controls, though these cells contained approximately 17% more protein than did controls. Opsonization of particles was not necessary for macrophages from either smoker or control animals to manifest a respiratory burst and increased superoxide and hydrogen peroxide release during phagocytosis. The glycolytic inhibitors, sodium fluoride and iodoacetamide, while effectively blocking glycolysis, did not inhibit phagocytosis by macrophages from either group. The results reported clearly distinguish alveolar macrophages from other phagocytic cells (peritoneal macrophages and polymorphonuclear leukocytes) and suggest a state of non-specific activation caused by exposure to tobacco smoke.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jcp.1040950113
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Dissociation of plasminogen activator from the transformed phenotype in a 5-Bromodeoxyuridine dependent mutant of syrian hamster melanoma cells (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 95 (1978), S. 275-285 
    Details
    ISSN: 0021-9541
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The relationship between plasminogen activator levels and the expression of the transformed phenotype was studied in a 5-bromodeoxyuridine (BrdUrd) dependent mutant of Syrian hamster melanoma cells. In terms of cell morphology and cellular interactions, the BrdUrd dependent cells resemble transformed cells when grown in the presence of BrdUrd but resemble untransformed cells when grown in the absence of BrdUrd. It was found that the BrdUrd dependent cells release significant levels of plasminogen activator only when cultured in the absence of BrdUrd. In the presence of BrdUrd, the release of plasminogen activator by the dependent cells is suppressed, and the decreased level of plasminogen activator released in the presence of BrdUrd seems to be due to decreased production of active enzyme. Growth tests revealed that the BrdUrd dependent cells, when attached to a substrate, required BrdUrd in order to attain high densities. Furthermore, the cells are able to grow well in soft agar only in the presence of BrdUrd. These results suggest that the production and release of high levels of plasminogen activator are not related (either as cause or effect) to the expression of the transformed phenotype in the BrdUrd dependent cellsThe effect of dog serum (as a plasminogen source) on the BrdUrd dependent cells also was tested. It was found that cells cultured in medium containing dog serum exhibit a morphological alteration, but only in the absence of BrdUrd. The morphological response of the cells to dog serum resembles that previously observed with virus-transformed cells. In the BrdUrd dependent cells, the morphological response to dog serum appears correlated with the release of plasminogen activator but separated from other transformed characteristics.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jcp.1040950305
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 4
    Digitale Medien
    Digitale Medien
    An immunocytochemical localization of the cortical granule lectin in fertilized and unfertilized eggs of xenopus laevis (1978)
    New York, NY : Wiley-Blackwell
    Gamete Research 1 (1978), S. 13-18 
    Details
    ISSN: 0148-7280
    Schlagwort(e): immunoperoxidase localization ; fertilization ; Xenopus laevis ; cortical reaction ; block to polyspermy ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie
    Notizen: At fertilization, the vitelline envelope surrounding the egg of Xenopus laevis is modified by the addition of an electron-dense component termed the “F layer.” The F layer functions as a block to polyspermy and as a block to the escape of macromolecules from the perivitelline space, thereby causing an osmotically driven envelope elevation. F-layer formation has been hypothesized to result from interaction between a cortical-granule lectin, released in the cortical reaction, and a jelly-coat ligand. Evidence for this hypothesis was sought by determining the location of the cortical-granule lectin both before and after fertilization, using a specific antibody conjugated to horseradish peroxidase. The cortical-granule lectin was localized only in the cortical granules of the unfertilized egg and was located predominantly in the perivitelline space and the F layer of a fertilized egg. These observations support the hypothesis that the F layer is formed by a cortical-granule-Iectin-jelly layer-ligand interaction.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/mrd.1120010104
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 5
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    Fluorinated molecule as a tracer: difluoroserotonin in human platelets mapped by electron energy-loss spectroscopy (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-05-05
    Beschreibung: The intracellular distribution of fluorine has been delineated in human platelets incubated with 4,6-difluoroserotonin, utilizing a scanning-transmission electron microscope equipped with an energy-loss spectrometer. Discrete intracellular structures corresponding in location to dense bodies contained high concentrations of fluorine. Electron energy-loss spectroscopy, which apparently can detect less than 10(-20) gram of fluorine in an area of 10 square nonometers, can thus localize fluorinated tracer molecules with biological activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Costa, J L -- Joy, D C -- Maher, D M -- Kirk, K L -- Hui, S W -- New York, N.Y. -- Science. 1978 May 5;200(4341):537-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644312" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Blood Platelets/*metabolism ; Energy Transfer ; *Fluorine ; Humans ; Microscopy, Electron/methods ; Serotonin/*analogs & derivatives/blood ; Spectrum Analysis/methods
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    Physostigmine: improvement of long-term memory processes in normal humans (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-07-21
    Beschreibung: Nineteen normal male subjects received 1.0 milligram of physostigmine or 1.0 milligram of saline by a slow intravenous infusion on two nonconsecutive days. Physostigmine significantly enhanced storage of information into long-term memory. Retrieval of information from long-term memory was also improved. Short-term memory processes were not significantly altered by physostigmine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, K L -- Mohs, R C -- Tinklenberg, J R -- Pfefferbaum, A -- Hollister, L E -- Kopell, B S -- New York, N.Y. -- Science. 1978 Jul 21;201(4352):272-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351807" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Acetylcholine/physiology ; Adolescent ; Adult ; Alzheimer Disease/drug therapy ; Clinical Trials as Topic ; Humans ; Male ; Memory/*drug effects/physiology ; Memory, Short-Term/drug effects ; Physostigmine/*pharmacology/therapeutic use
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
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    Nicotine in breast fluid of nonlactating women (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-01-20
    Beschreibung: Using a combination of gas chromatography, mass spectrometry, and selected ion recording techniques, we have identified nicotine and its major metabolite, continine, in the breast fluid of nonlactating women smokers. As little as 25 picograms could be measured by using the deuterated variants, [5',5'-2H]nicotine and [3,3-2H]cotinine, both as internal standards and as carriers in an inverse isotope dilution method.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Petrakis, N L -- Gruenke, L D -- Beelen, T C -- Castagnoli, N Jr -- Craig, J C -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):303-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/619458" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Body Fluids/analysis ; Breast/*analysis ; Cotinine/analysis ; Female ; Humans ; Nicotine/*analysis ; Smoking
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    Preferential utilization of free cholesterol from high-density lipoproteins for biliary cholesterol secretion in man (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1978-04-07
    Beschreibung: High- and low-density lipoproteins carrying free cholesterol labeled with 3H or 14C were administered to a patient with a bile fistula. The free cholesterol from high-density lipoproteins was more rapidly incorporated into biliary cholesterol than the free cholesterol from low-density lipoproteins. These findings show that the liver in man selectively utilizes and secretes the free cholesterol from a particular lipoprotein.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schwartz, C C -- Halloran, L G -- Vlahcevic, Z R -- Gregory, D H -- Swell, L -- New York, N.Y. -- Science. 1978 Apr 7;200(4337):62-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/204996" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Aged ; Bile/*metabolism ; Cholesterol/blood/*metabolism ; Coronary Disease/metabolism ; Erythrocytes/metabolism ; Female ; Humans ; Lipoproteins, HDL/*metabolism ; Lipoproteins, LDL/*metabolism ; Liver/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    Interplanetary propagation of flare-associated energetic particles (1978)
    In:  CASI
    Details
    Publikationsdatum: 2019-06-27
    Beschreibung: A propagation model which combines a Gaussian profile for particle release from the sun, with interplanetary particle densities predicted by focused diffusion, was proposed to explain the propagation history of flare associated energetic particles. This model, which depends on only two parameters, successfully describes the time-intensity profiles of 30 proton and electron events originating from the western hemisphere of the sun. Generally, particles are released from the sun over a finite interval. In almost all events, particle release begins at the time of flare acceleration.
    Schlagwort(e): ASTROPHYSICS
    Materialart: NASA-TM-79534
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 10
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    The velocity distribution of interstellar gas observed in strong UV absorption lines (1978)
    In:  Other Sources
    Details
    Publikationsdatum: 2019-06-27
    Beschreibung: Observations of three strong interstellar UV absorption lines of N I (1199 A), N II (1083 A), and Si III (1206 A) in 47 stars of widely varying distance and a variety of spectral types are analyzed to obtain a velocity distribution function for the interstellar gas. A technique based on the maximum and minimum velocities observed along a line of sight is adopted because of heavy line blending, and results are discussed for both power-law and exponential distribution functions. The expected distribution of radiative-phase supernova remnants (SNRs) in the interstellar medium is calculated as a function of SNR birthrate and of the interstellar density in which they evolve. The results are combined with observed distance estimates, and it is shown that an interstellar density in excess of 0.1 per cu cm would be required to keep the SNRs sufficiently confined so that their cross sections are consistent with the observed number of components. The alternative possibility is considered that SNRs do not enter the radiative phase before escaping from the Galaxy or colliding with neighboring remnants.
    Schlagwort(e): ASTROPHYSICS
    Materialart: Astrophysical Journal; vol. 223
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
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