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  • Articles  (9)
  • Hindawi  (9)
  • 2015-2019  (9)
  • 1985-1989
  • 1970-1974
  • Journal of Chemistry  (3)
  • 94192
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  • Articles  (9)
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  • Hindawi  (9)
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  • 1
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    Adsorption of Basic Brown and Chrysophenine from Water Solution by Magnesium Silicate Gel (2015)
    Hindawi
    Details
    Publication Date: 2015-09-21
    Description: Noncrystalline, high surface area magnesium silicate gel was successfully prepared by hydrothermal method. Such product was characterized by BET and XRD to determine surface area 576.4 m2·g−1, average pore width 2.76 nm, and amorphous surface. The adsorption behaviors of Basic Brown and Chrysophenine on magnesium silicate gel were investigated through changing initial concentration, adsorbent dosage, solution pH, contact time, and temperature. The experimental data was analyzed by the adsorption isotherms and kinetics. The results showed the adsorption progress was fast for Basic Brown, and the adsorption equilibrium was finished in 2 h, while the adsorption equilibrium of Chrysophenine was finished in 7 h. Freundlich isotherm model and second-order kinetic models described the adsorption process very well.
    Print ISSN: 2090-9063
    Topics: Chemistry and Pharmacology
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  • 2
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    Study on Molecular Recognition between Euphorbia Factor L713283 and β-Tubulin via Molecular Simulation Methods (2015)
    Hindawi
    Details
    Publication Date: 2015-11-24
    Description: Euphorbia factor L713283 is a new lathyrane diterpene isolated from Euphorbia lathyris and shows strong anticancer activity. By using molecular similarity analysis, β-tubulin was identified as one of the possible targets of L713283. We further investigated the binding modes of L713283 with β-tubulin using molecular docking and molecular dynamics (MD) simulation methods. The results indicated that the binding site between β-tubulin and L713283 was composed of the four regions, that is, residues Phe20~Glu27, Leu225~Thr232, Phe270~Gly277, and Ile356~Met363. MM/GBSA method was used to calculate the binding free energy and determine the key residues for the association of L713283 with β-tubulin. It was found that nonpolar interactions made the major contributions for the binding. In addition, we compared the binding pocket and motion modes of L713283-free and L713283-bound β-tubulin systems. It is proposed that L713283 may bind to β-tubulin and favor the formation of αβ-tubulin dimmer. This work provides possible explanation for molecular mechanism of the anticancer agent L713283, and the strategy used here could benefit the investigation of possible target profile for those bioactive agents with unknown mechanisms.
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    Topics: Chemistry and Pharmacology
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  • 3
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    Anti-Inflammatory Effect of By-Products from Haliotis discus hannai in RAW 264.7 Cells (2015)
    Hindawi
    Details
    Publication Date: 2015-03-13
    Description: Several reports promoted the potential of shellfish due to their ability to act as antioxidant, anti-inflammatory, and antimicrobial agents. Pacific abalone, Haliotis discus hannai viscera is, reported to possess bioactivities such as antioxidative stress and anti-inflammatory. In this study, anti-inflammatory potential of mucus-secreting glands from shell-shucking waste of H. discus hannai was evaluated using RAW 264.7 mouse macrophage cell model. Results indicated that presence of H. discus hannai mucosubstance by-products (AM) significantly lowered the nitric oxide (NO) production along the expressional suppression of inflammatory mediators such as cytokines TNF-α, IL-1β, and IL-6 and enzymes iNOS and COX-2. Also, AM was shown to increase expression of anti-inflammatory response mediator HO-1. Presence of AM also scavenged the free radicals in vitro. In conclusion, by-products of H. discus hannai are suggested to possess notable anti-inflammatory potential which promotes the possibility of utilization as functional food ingredient.
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    Topics: Chemistry and Pharmacology
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  • 4
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    Anti-Inflammatory Effect of By-Products fromHaliotis discus hannaiin RAW 264.7 Cells (2015)
    Hindawi
    Details
    Publication Date: 2015-01-01
    Description: Several reports promoted the potential of shellfish due to their ability to act as antioxidant, anti-inflammatory, and antimicrobial agents. Pacific abalone,Haliotis discus hannaiviscera is, reported to possess bioactivities such as antioxidative stress and anti-inflammatory. In this study, anti-inflammatory potential of mucus-secreting glands from shell-shucking waste ofH. discus hannaiwas evaluated using RAW 264.7 mouse macrophage cell model. Results indicated that presence ofH. discus hannaimucosubstance by-products (AM) significantly lowered the nitric oxide (NO) production along the expressional suppression of inflammatory mediators such as cytokines TNF-α, IL-1β, and IL-6 and enzymes iNOS and COX-2. Also, AM was shown to increase expression of anti-inflammatory response mediator HO-1. Presence of AM also scavenged the free radicalsin vitro. In conclusion, by-products ofH. discus hannaiare suggested to possess notable anti-inflammatory potential which promotes the possibility of utilization as functional food ingredient.
    Print ISSN: 2090-9063
    Electronic ISSN: 2090-9071
    Topics: Chemistry and Pharmacology
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  • 5
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    Molecular Cloning and Expression Analysis of Cu/Zn SOD Gene from Gynura bicolor DC. (2017)
    Hindawi
    Details
    Publication Date: 2017-01-01
    Description: Superoxide dismutase is an important antioxidant enzyme extensively existing in eukaryote, which scavenges reactive oxygen species (ROS) and plays an essential role in stress tolerance of higher plants. A full-length cDNA encoding Cu/Zn SOD was cloned from leaves of Gynura bicolor DC. by rapid amplification of cDNA ends (RACE). The full-length cDNA of Cu/Zn SOD is 924 bp and has a 681 bp open reading frame encoding 227 amino acids. Bioinformatics analysis revealed that belonged to the plant SOD super family. Cu/Zn SODs of the Helianthus annuus, Mikania micrantha, and Solidago canadensis var. scabra all have 86% similarity to the G. bicolor Cu/Zn SOD. Analysis of the expression of Cu/Zn SOD under different treatments revealed that Cu/Zn SOD was a stress-responsive gene, especially to 1-MCP. It indicates that the Cu/Zn SOD gene would be an important gene in the resistance to stresses and will be helpful in providing evidence for future research on underlying molecular mechanism and choosing proper postharvest treatments for G. bicolor.
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    Topics: Chemistry and Pharmacology
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  • 6
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    Synthesis and Anticancer Activities of 4-[(Halophenyl)diazenyl]phenol and 4-[(Halophenyl)diazenyl]phenyl Aspirinate Derivatives against Nasopharyngeal Cancer Cell Lines (2017)
    Hindawi
    Details
    Publication Date: 2017-01-01
    Description: Aspirin and azo derivatives have been widely studied and have drawn considerable attention due to diverse biological activities. In this study, a series of 4-[(halophenyl)diazenyl]phenyl aspirinate derivatives were synthesized from the reaction of aspirin with 4-[(halophenyl)diazenyl]phenol via esterification, in the presence of DCC/DMAP in DCM with overall yield of 45–54%. 4-[(Halophenyl)diazenyl]phenol was prepared prior to esterification from coupling reaction of aniline derivatives and phenol in basic solution. All compounds were characterized using elemental analysis, FTIR, and 1H and 13C NMR spectroscopies. All compounds were screened for their anticancer activities against nasopharyngeal cancer (NPC) HK-1 cell lines and the viability of cultured cells was determined by MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxylmethoxylphenyl)-2-(4-sulfophenyl)-2H-tetrazolium]-based colorimetric assay. 4-[(E)-(Fluorophenyl)diazenyl]phenol showed the highest anticancer activity against NPC HK-1 cell lines compared to other synthesized compounds. 4-[(Halophenyl)diazenyl]phenyl aspirinate showed low cytotoxicity against NPC HK-1 cell lines compared to 4-[(halophenyl)diazenyl]phenol but better anticancer activity than aspirin alone.
    Print ISSN: 2090-9063
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    Topics: Chemistry and Pharmacology
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  • 7
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    Study on Molecular Recognition betweenEuphorbia FactorL713283 andβ-Tubulin via Molecular Simulation Methods (2015)
    Hindawi
    Details
    Publication Date: 2015-01-01
    Description: Euphorbia factorL713283 is a new lathyrane diterpene isolated fromEuphorbia lathyrisand shows strong anticancer activity. By using molecular similarity analysis,β-tubulin was identified as one of the possible targets of L713283. We further investigated the binding modes of L713283 withβ-tubulin using molecular docking and molecular dynamics (MD) simulation methods. The results indicated that the binding site betweenβ-tubulin and L713283 was composed of the four regions, that is, residues Phe20~Glu27, Leu225~Thr232, Phe270~Gly277, and Ile356~Met363. MM/GBSA method was used to calculate the binding free energy and determine the key residues for the association of L713283 withβ-tubulin. It was found that nonpolar interactions made the major contributions for the binding. In addition, we compared the binding pocket and motion modes of L713283-free and L713283-boundβ-tubulin systems. It is proposed that L713283 may bind toβ-tubulin and favor the formation ofαβ-tubulin dimmer. This work provides possible explanation for molecular mechanism of the anticancer agent L713283, and the strategy used here could benefit the investigation of possible target profile for those bioactive agents with unknown mechanisms.
    Print ISSN: 2090-9063
    Electronic ISSN: 2090-9071
    Topics: Chemistry and Pharmacology
    Published by Hindawi
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  • 8
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    Adsorption of Basic Brown and Chrysophenine from Water Solution by Magnesium Silicate Gel (2015)
    Hindawi
    Details
    Publication Date: 2015-01-01
    Description: Noncrystalline, high surface area magnesium silicate gel was successfully prepared by hydrothermal method. Such product was characterized by BET and XRD to determine surface area 576.4 m2·g−1, average pore width 2.76 nm, and amorphous surface. The adsorption behaviors of Basic Brown and Chrysophenine on magnesium silicate gel were investigated through changing initial concentration, adsorbent dosage, solution pH, contact time, and temperature. The experimental data was analyzed by the adsorption isotherms and kinetics. The results showed the adsorption progress was fast for Basic Brown, and the adsorption equilibrium was finished in 2 h, while the adsorption equilibrium of Chrysophenine was finished in 7 h. Freundlich isotherm model and second-order kinetic models described the adsorption process very well.
    Print ISSN: 2090-9063
    Electronic ISSN: 2090-9071
    Topics: Chemistry and Pharmacology
    Published by Hindawi
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  • 9
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    Anthocyanin Retention of Cranberry (Vaccinium macrocarpon) Juice Subjected to Different Nanofiltration Conditions (2017)
    Hindawi
    Details
    Publication Date: 2017-01-01
    Description: The aim of this work was to evaluate the retention of anthocyanin during a nanofiltration process of cranberry juice. Nanofiltration membranes, HC-50P DDS with an effective area of 0.36 m2 in a plate/frame nanofilter system, DDS Lab Module, were used for the experiments. Juice feed flow rate varied from 1.0 to 12.0 L min−1 at transmembrane pressures between 20 and 40 bar (2026 and 4052 kPa). Permeate flux reached a maximum value of 41.3 L h−1 m−2 at a pressure of 40 bar and a feed rate of 12 L min−1, showing a direct dependency on these two parameters. Retention coefficients of anthocyanin of 0.94 to 0.99 corresponding to percentage recovery between 93 and 99% were obtained. Total anthocyanin content increased to values between 237 and 287 mg L−1 from original concentration of 82 to 97 mg L−1 in feed solution. Total soluble solids were also retained on the nanofilter. Both anthocyanin retentate and permeate obtained by nanofiltration could be potential functional ingredients for the food and nutraceutical industry.
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    Topics: Chemistry and Pharmacology
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