Please enable Javascript in your browser preferences in order to use all features of ALBERT.

ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Hits per page

hits 1 - 2 | 2 hits

Sorting

1

facet.materialart.

Unknown

Base metal-catalyzed benzylic oxidation of (aryl)(heteroaryl)methanes with molecular oxygen (2016)

Hans Sterckx, Johan De Houwer, Carl Mensch, Wouter Herrebout, Kourosch Abbaspour Tehrani and Bert U. W. Maes

Beilstein-Institut

In: Beilstein Journal of Organic Chemistry

add to mindlist on the mindlist

Details

Publication Date: 2016-01-28

Description: The methylene group of various substituted 2- and 4-benzylpyridines, benzyldiazines and benzyl(iso)quinolines was successfully oxidized to the corresponding benzylic ketones using a copper or iron catalyst and molecular oxygen as the stoichiometric oxidant. Application of the protocol in API synthesis is exemplified by the alternative synthesis of a precursor to the antimalarial drug Mefloquine. The oxidation method can also be used to prepare metabolites of APIs which is illustrated for the natural product papaverine. ICP–MS analysis of the purified reaction products revealed that the base metal impurity was well below the regulatory limit. Beilstein J. Org. Chem. 2016, 12, 144–153. doi:10.3762/bjoc.12.16

Keywords: base metalbenzyliccatalyzedmolecular oxygenoxygenation

Electronic ISSN: 1860-5397

Topics: Chemistry and Pharmacology

Published by Beilstein-Institut

Permalink

	Location	Call Number	Expected	Availability

BibTip

Others were also interested in ...

PAPER CURRENT

2

facet.materialart.

Unknown

Base metal-catalyzed benzylic oxidation of (aryl)(heteroaryl)methanes with molecular oxygen (2016)

Sterckx, Hans ; De Houwer, Johan ; Mensch, Carl ; [et al.]

Beilstein-Institut

In: Beilstein Journal of Organic Chemistry. 2016; 12: 144-153. Published 2016 Jan 27. doi: 10.3762/bjoc.12.16.

add to mindlist on the mindlist

Details

Publication Date: 2016-01-27

Description: The methylene group of various substituted 2- and 4-benzylpyridines, benzyldiazines and benzyl(iso)quinolines was successfully oxidized to the corresponding benzylic ketones using a copper or iron catalyst and molecular oxygen as the stoichiometric oxidant. Application of the protocol in API synthesis is exemplified by the alternative synthesis of a precursor to the antimalarial drug Mefloquine. The oxidation method can also be used to prepare metabolites of APIs which is illustrated for the natural product papaverine. ICP–MS analysis of the purified reaction products revealed that the base metal impurity was well below the regulatory limit.

Print ISSN: 2195-951X

Electronic ISSN: 1860-5397

Topics: Chemistry and Pharmacology

Published by Beilstein-Institut

Permalink

	Location	Call Number	Expected	Availability

BibTip

Others were also interested in ...

PAPER CURRENT

hits 1 - 2 | 2 hits

This website uses cookies and the analysis tool Matomo. More information can be found here...