ALBERT

Beschreibung: Author(s): Long Jun Wang (王龙军), Jian Min Dong (董建敏), and Wen Hui Long (龙文辉) Tensor effects on the N =40 gap evolution of N =40 isotones are studied by employing the Skyrme-Hartree-Fock-Bogoliubov (SHFB) and relativistic Hartree-Fock-Bogoliubov (RHFB) theories. The results with and without the inclusion of the tensor components are compared with each other. It is found that wh... [Phys. Rev. C 87, 047301] Published Mon Apr 01, 2013

Beschreibung: Author(s): Long Jun Wang (王龙军), Bao Yuan Sun (孙保元), Jian Min Dong (董建敏), and Wen Hui Long (龙文辉) The odd-even staggerings (OESs) on nuclear binding energies are studied systematically within the spherical covariant density functional (CDF) theories, specifically the relativistic Hartree-Fock-Bogoliubov (RHFB) and the relativistic Hartree-Bogoliubov (RHB) theories. When taking the finite-range G... [Phys. Rev. C 87, 054331] Published Tue May 28, 2013

Beschreibung: Key Points EBV LMP1 dysregulates EphA4 expression via the ERK-Sp1 pathway. Downregulation of EphA4 is demonstrated in EBV+ DLBCL, which is significantly correlated with poor DLBCL survival.

Beschreibung: Acute myeloid leukemia (AML) is derived from small populations of leukemia stem cells (LSCs) characterized by the self-renewal and chemoresistant properties. Residual LSCs after chemotherapy remain as the critical barriers to cure. Clearance of LSCs might rationally lead to an improvement of clinical outcome. Recently studies showed that JAK/STAT signaling play an important role in the self-renewal of AML-LSCs due to increased growth factor (GF) receptor expression such as c-kit, FLT3, CD123 and altered GF signaling by activating tyrosine kinases. Therefore, targeting such tyrosine kinases might be a strategy to eliminate LSCs. Anlotinib displayed its anti-tumor activity in lung cancer by targeting tyrosine kinase of VEGFR, FGFR, PDGFR and c-kit. However, whether anlotinib could inhibit the GF receptor-related tyrosine kinase overactivation and its downstream JAK-STAT signaling, and subsequently kill LSCs or regulate LSCs biology remains largely unknown. To explore whether anlotinib could exert effective ani-LSCs activity, we treated LSC like cell lines (CD34+CD38-KG-1 and Kasumi-1) with anlotinib, and found anlotinib could effectively induce apoptosis of LSC-like cells in a dose- and time-dependent manner. Similar results were observed in primary CD34+CD38-AML LSCs; notably, anlotinib did not significantly kill normal CD34+ cells in vitro. Additionally, the anti-LSC activity of anlotinib was further confirmed in the xenograft mouse model by injection of Kasumi cells (LSC-like cell line) into irradiated female BALB/c nude mice. To determine whether anlotinib could inhibit the over activation of the GF receptor-related tyrosine kinase, we performed western blot at 12h after anlotinib treatment when LSC-like cells did not showed significant apoptosis. As a result, anlotinib inhibit c-kit phosphorylation and JAK2 activation. Intriguingly, unlike JAK2 inhibitors, anlotinib could not only the inhibit phosphorylation of STAT3 and STAT5 but also downregulate their expression. Chemoresistance and immune evasion were the key features of LSCs, JAK2-STAT3/5 signaling was reported to involved in chemoresistance by upregulating anti-apoptotic proteins such as Bcl-2 ,Mcl-1 and also involved in immune escape by inducing immune suppressive molecules such as PD-L1 ,TGF-β.Thus we evaluated Bcl-2 expression and found a significant decrease in LSC-likes cells after anlotinib treatment. Similarly, PD-L1 and TGF-β were also significantly downregulated after anlotinib treatment. In conclusion, anlotinib not only displayed the effective anti-LSCs activity but also might regulate the chemoresistance and immune evasion of LSC by downregulating the anti-apoptotic proteins and suppressive molecules such as PD-L1, TGF-β respectively. Consequently, anlotinib might has the potential to contribute to a deeper clearance of LSCs by combining with chemotherapy or immunotherapy. Disclosures No relevant conflicts of interest to declare.

Beschreibung: Author(s): Ren-hong Fang, Long-gang Pang, Qun Wang, and Xin-nian Wang Fermions become polarized in a vortical fluid due to spin-vorticity coupling. Such a polarization can be calculated from the Wigner function in a quantum kinetic approach. By extending previous results for chiral fermions, we derive the Wigner function for massive fermions up to next-to-leading orde… [Phys. Rev. C 94, 024904] Published Tue Aug 02, 2016

Beschreibung: Author(s): Long Zhu, Jun Su, and Feng-Shou Zhang Within the framework of a dinuclear system model, the influence of projectile and target neutron number on capture cross section, fusion probability, and survival probability for the reactions S 34 , 36 + U 238 and Ca 48 + Pu 239 , 240 , 242 , 244 are investigated. The calculated excitation functions are in good ag… [Phys. Rev. C 93, 064610] Published Wed Jun 22, 2016

Beschreibung: Author(s): Jia Jie Li (李佳杰), Wen Hui Long (龙文辉), Jun Ling Song (宋军领), and Qiang Zhao (赵强) The occurrence of the bubble-like structure has been studied, in the light of pseudospin degeneracy, within the relativistic Hartree-Fock-Bogoliubov (RHFB) theory. It is concluded that the charge/neutron bubble-like structure is predicted to occur in the mirror system of { Si 34 , Ca 34 } commonly by the … [Phys. Rev. C 93, 054312] Published Mon May 09, 2016

Beschreibung: Author(s): R. Talwar, T. Adachi, G. P. A. Berg, L. Bin, S. Bisterzo, M. Couder, R. J. deBoer, X. Fang, H. Fujita, Y. Fujita, J. Görres, K. Hatanaka, T. Itoh, T. Kadoya, A. Long, K. Miki, D. Patel, M. Pignatari, Y. Shimbara, A. Tamii, M. Wiescher, T. Yamamoto, and M. Yosoi Background: The Ne 22 ( α , n ) Mg 25 reaction is the dominant neutron source for the slow neutron capture process ( s process) in massive stars, and contributes, together with C 13 ( α , n ) O 16 , to the production of neutrons for the s process in asymptotic giant branch (AGB) stars. However, the reaction is endoth… [Phys. Rev. C 93, 055803] Published Tue May 10, 2016

Beschreibung: Author(s): Huai-Qiang Gu (顾怀强), Haozhao Liang (梁豪兆), Wen Hui Long (龙文辉), Nguyen Van Giai, and Jie Meng (孟杰) The relativistic local density approximation (LDA) for the Coulomb exchange functional in nuclear systems is presented. This approximation is composed of the well-known Slater approximation in the nonrelativistic scheme and the corrections due to the relativistic effects. Its validity in finite nucl... [Phys. Rev. C 87, 041301] Published Mon Apr 01, 2013

Beschreibung: Author(s): Taofeng Wang, Guangwu Li, Liping Zhu, Qinghua Meng, Liming Wang, Hongyin Han, Wenhui Zhang, Haihong Xia, Long Hou, Ramona Vogt, and Jørgen Randrup The dependence of correlations of neutron multiplicity ν and γ -ray multiplicity M γ in spontaneous fission of Cf 252 on fragment mass A * and total kinetic energy (TKE) have been investigated by employing the ratio of M γ / ν and the form of M γ ( ν ) . We show for the first time that M γ and ν have a complex c… [Phys. Rev. C 93, 014606] Published Fri Jan 08, 2016